scholarly journals SuO006TWO MAJOR INSULIN RESISTANCE GENES (SIRT1 AND SIRT6) ARE ASSOCIATED WITH CONCENTRIC LEFT VENTRICULAR HYPERTROPHY IN END STAGE KIDNEY DISEASE

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii45-iii46
Author(s):  
Belinda Spoto ◽  
Alessandra Testa ◽  
Rosa M Parlongo ◽  
Maria C Sanguedolce ◽  
Graziella D'Arrigo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Kidney Disease ◽  
Left Ventricular Hypertrophy ◽  
Resistance Genes ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
End Stage Kidney Disease ◽  
Concentric Left Ventricular Hypertrophy ◽  
End Stage

scholarly journals FP616ECCENTRIC LEFT VENTRICULAR HYPERTROPHY IS A MAJOR RISK FACTOR FOR SUDDEN DEATH IN PATIENTS WITH END-STAGE KIDNEY DISEASE

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii278-iii278
Author(s):  
Camiel LM de Roij van Zuijdewijn ◽  
Romy Hansildaar ◽  
Menso J Nube ◽  
Piet M ter Wee ◽  
Michiel L Bots ◽  
...  
Keyword(s):  
Risk Factor ◽  
Kidney Disease ◽  
Sudden Death ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Major Risk Factor ◽  
End Stage Kidney Disease ◽  
End Stage

Eccentric Left Ventricular Hypertrophy and Sudden Death in Patients with End-Stage Kidney Disease

2015 ◽  
Vol 42 (2) ◽  
pp. 126-133 ◽  
Author(s):  
Camiel L.M. de Roij van Zuijdewijn ◽  
Romy Hansildaar ◽  
Michiel L. Bots ◽  
Peter J. Blankestijn ◽  
Marinus A. van den Dorpel ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Sudden Death ◽  
Left Ventricular Hypertrophy ◽  
Cardiovascular Mortality ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Convective Transport ◽  
End Stage Kidney Disease ◽  
All Cause Mortality ◽  
End Stage

Background/Aims: Both all-cause and cardiovascular mortality risks are extremely high in patients with end-stage kidney disease (ESKD). Sudden death accounts for approximately one-quarter of all fatal events. Left ventricular hypertrophy (LVH) is a known risk factor for mortality and can be divided in 2 types: concentric and eccentric. This study evaluated possible differences in all-cause mortality, cardiovascular mortality and sudden death between prevalent ESKD patients with concentric and eccentric LVH. Methods: Participants of the CONvective TRAnsport STudy (CONTRAST) who underwent transthoracic echocardiography (TTE) at baseline were analyzed. In patients with LVH, a relative wall thickness of ≤0.42 was considered eccentric and >0.42 was considered concentric hypertrophy. Cox proportional hazards models, adjusted for potential confounders, were used to calculate hazard ratios (HRs) of patients with eccentric LVH versus patients with concentric LVH for all-cause mortality, cardiovascular mortality and sudden death. Results: TTE was performed in 328 CONTRAST participants. LVH was present in 233 participants (71%), of which 87 (37%) had concentric LVH and 146 (63%) eccentric LVH. The HR for all-cause mortality of eccentric versus concentric LVH was 1.14 (p = 0.52), 1.79 (p = 0.12) for cardiovascular mortality and 4.23 (p = 0.02) for sudden death in crude analyses. Propensity score-corrected HR for sudden death in patients with eccentric LVH versus those with concentric LVH was 5.22 (p = 0.03). Conclusions: (1) The hazard for all-cause mortality, cardiovascular mortality and sudden death is markedly increased in patients with LVH. (2) The sudden death risk is significantly higher in ESKD patients with eccentric LVH compared to subjects with concentric LVH.

Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1

2003 ◽  
Vol 41 (6) ◽  
pp. 1219-1224 ◽  
Author(s):  
Anne Lumiaho ◽  
Jussi Pihlajamäki ◽  
Juha Hartikainen ◽  
Risto Ikäheimo ◽  
Raija Miettinen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Kidney Disease ◽  
Left Ventricular Hypertrophy ◽  
Polycystic Kidney Disease ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Disease Type ◽  
Polycystic Kidney

scholarly journals Anemia and inflammation, a link between end stage kidney disease and left ventricular hypertrophy

2019 ◽  
Vol 6 (5) ◽  
pp. 1539
Author(s):  
T. Madhusudhana Rao ◽  
B. H. V. K. Praveen Varma ◽  
D. S. S. K. Raju
Keyword(s):  
Kidney Disease ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
End Stage Kidney Disease ◽  
Tnf Α ◽  
The Mean ◽  
End Stage ◽  
Serum Crp

Background: Based on Glomerular Filtration Rate (GFR) Chronic Kidney Disease patients are classified into five stages. It starts with early stage of CKD and finally ends with End Stage Kidney Disease (ESKD). Anemia and inflammation are major medical complication in End Stage Kidney Disease and leads cardio vascular complications like LVH.Methods: A cross sectional study carried out over a 2 year period in Department Nephrology and General Medicine OPD, MIMS, Vizianagaram, Andhra Pradesh, India 120 in which 60 are normal healthy individuals and 60 are End stage kidney Disease. In all the participants Serum creatinine, blood urea, Serum Iron, TIBC, TSAT% Serum ferritin, Serum CRP, IL-6 and TNF-α was measured. All the EDTA blood samples were analyzed for complete blood count. Results: The diagnostic criteria for CKD like blood urea and serum creatinine were significantly higher in ESKD. There is a significantly increased level of Left ventricular mass index in ESKD when compared with Control. The mean erythrocyte indices are decreased in ESKD. The mean serum iron, TIBC and TSAT% decreased ESKD. Whereas serum ferritin significant increase in ESKD group and the mean serum CRP IL-6 and TNF-α significant increase in ESKD group when compared with controlConclusion: Present study finding suggested that there is a raised inflammatory marker in ESKD patients due to inflammation and it further changes serum ferritin, serum iron and TIBC. The above altered factors leads to changes in erythrocyte indices and leads to anemia which ends with cardiovascular complication like Left Ventricular Hypertrophy.

SURVEY OF CARDIOVASCULAR RISK FACTORS AND ELECTROCARDIGRAPHIC, ECHOCARDIOGRAPHIC ABNORMALITIES IN PATIENTS ON WAITING LIST FOR RENAL TRANSPLANTATION

2014 ◽  
pp. 26-30
Author(s):  
Huu Thinh Nguyen ◽  
Thi Thuy Hang Nguyen ◽  
Bui Bao Hoang
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Renal Transplantation ◽  
Left Ventricular Hypertrophy ◽  
Cardiovascular Risk Factors ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Valve Insufficiency ◽  
Transplant Candidates ◽  
End Stage

Background: Cardiovascular disease is the major cause of death in dialysis patients, as well as in kidney transplant patients. Assessment of cardiovascular risks of renal transplant candidates to prevent or slow the progression of cardiovascular abệnh nhânormalities. Aim: 1) Evaluating cardiovascular risk factors, electrocardiographic and echocardiographic abnormalities in renal transplant candidates. 2) Identifying the correlation between cardiac morphological parameters with a number of factors involved. Subjects and Methods: We assessed 57 patients (73.7% male, mean age 32.4±8.8) with end-stage renal disease waiting for renal transplantation at Cho Ray Hospital between Jan 2012 and Jan 2013. All patients received a physical examination, blood pressure measurement, Hb, blood glucose test, lipid profile, ECG, echocardiography. Results: The percentage of hypertension was 98.2%, smoking (69.2%), dyslipidemia 40.4% and diabetes 12.3%. All patients had sinus rhythm, left ventricular hypertrophy 61.4% in ECG. Pericardial effusion 5.3%, mitral valve insufficiency 56.1%, aortic valve insufficiency 12.3%, left ventricular hypertrophy 94.7% in echocardiography. IVSd, LVPWd, LVMI positively correlated with kidney failure time (p <0.01, p<0.001), with DBP and SBP (p <0.05) and the degree of anemia (p <0.05). Percentage the degree of hypertension associated with proportion of left ventricular hypertrophy (p <0.05). Conclusions: Identification of cardiovascular risk factors for the prevention or intervention to reduce mortality in renal transplantation. Keywords: Cardiovascular risk factors, end-stage chronic renal failure, renal transplantation.

EVALUATION OF LEFT VENTRICULAR MASS IN THE PREHYPERTENSIVES BY ELECTROCARDIOGRAPHY AND ECHOCARDIOGRAPHY

2011 ◽  
pp. 119-125
Author(s):  
Thi Thuy Hang Nguyen
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Structural Changes ◽  
Left Ventricular ◽  
Control Group ◽  
Concentric Left Ventricular Hypertrophy ◽  
Increased Risk ◽  
Lv Mass ◽  
Left Ventricular Morphology

Objective: Prehypertensive individuals are at increased risk for developing hypertension and their complication. Many studies show that 2/3 prehypertensive individuals develop hypertension after 4 years. ECG and echocardiography are the routine tests used to assess LV mass. The objective of the research to determine the percentage of change in left ventricular morphology in the ECG, echocardiography, which explore the characteristics of left ventricular structural changes by echocardiography in pre-hypertensive subjects. Materials and method: We studied a total of 50 prehypertensive, 30 males (60%) and 20 females (40%), mean age 48.20±8.47years. 50 normotensive volunteers as control participants. These subjects were examined for ECG and echocardiography. Results: In prehypertensive group, with 18% of left ventricular hypertrophy on electrocardiogram, 12% of left ventricular hypertrophy on echocardiography; in the control group, we did not find any subjects with left ventricular hypertrophy. In the group with left ventricular hypertrophy, mostly eccentric left ventricular hypertrophy (83.33%), concentric left ventricular hypertrophy is 16.67%. Restructuring of left ventricular concentric for 15.9% of subjects without left ventricular hypertrophy on echocardiography. Conclusion: There have been changed in left ventricular morphology even in prehypertensive

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