scholarly journals FP562SUPPRESSIVE EFFECT OF ASTAXANTIN ON EPITHERIAL MESENCHYMAL TRANSITION IN MESOTHELIAL CELLS ISOLATED FROM TEMPARATURE SENSITIVE SV40 LARGE T ANTIGEN GENE TRANSGENIC RATS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii261-iii262
Author(s):  
Kazuaki Hara ◽  
Chieko Hamada ◽  
Yasuhiko Tomino
Keyword(s):  
Mesothelial Cells ◽  
T Antigen ◽  
Large T Antigen ◽  
Transgenic Rats ◽  
Sv40 Large T Antigen ◽  
Mesenchymal Transition ◽  
Antigen Gene

scholarly journals Agonists stimulated cAMP response in renal cell lines established from transgenic mice harboring SV40 large T antigen gene.

1994 ◽  
Vol 64 ◽  
pp. 177
Author(s):  
Makoto Hosoyamada ◽  
Michio Takeda ◽  
Akiko Mizuno ◽  
Takashi Sekine ◽  
Hitoshi Endou
Keyword(s):  
Transgenic Mice ◽  
Cell Lines ◽  
Renal Cell ◽  
T Antigen ◽  
Large T Antigen ◽  
Sv40 Large T Antigen ◽  
Antigen Gene ◽  
Renal Cell Lines

scholarly journals Developmental regulation of lck gene expression in T lymphocytes.

1991 ◽  
Vol 173 (2) ◽  
pp. 383-393 ◽  
Author(s):  
R S Wildin ◽  
A M Garvin ◽  
S Pawar ◽  
D B Lewis ◽  
K M Abraham ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Short Interval ◽  
T Antigen ◽  
Lymphoid Cells ◽  
Proximal Promoter ◽  
Large T Antigen ◽  
Sv40 Large T Antigen ◽  
Promoter Sequences ◽  
Antigen Gene ◽  
Distal Promoter

In the mouse and human, mRNA transcripts encoding the lymphocyte-specific protein tyrosine kinase p56lck are derived from two separate promoters resulting in heterogeneity in the 5' untranslated region sequence. The proximal promoter lies just 5' to the coding region for the gene and is active only in thymocytes. In contrast, the distal promoter lies 34 kilobases (kb) 5' in the human, and is active both in thymocytes and mature peripheral T cells. As previously reported, transgenic mice bearing functional proximal promoter sequence juxtaposed with the SV40 large T antigen gene invariably develop lymphoid tumors confined to the thymus. In the current work, transgenic mice bearing a 2.6-kb fragment of the human distal promoter fused to the SV40 large T antigen gene express large T antigen in thymocytes and in peripheral lymphoid cells, and develop tumors of both the thymus and the peripheral lymphoid organs. The ability of the human distal promoter to function appropriately in transgenic mice is consistent with the strong similarity observed between the mouse and human distal promoter sequences. With the exception of a single short interval that serves as a target for binding of nuclear factors, significant sequence similarity is not seen when the distal and proximal promoter sequences are compared. Hence, developmentally regulated, lineage-specific transcription of the lck gene is mediated by distinct promoter sequences that appear to be capable of functioning independently.

A fragment of the SV40 large T-antigen gene transforms

Nature ◽  
1982 ◽  
Vol 299 (5878) ◽  
pp. 59-61 ◽  
Author(s):  
Christine E. Clayton ◽  
David Murphy ◽  
Michael Lovett ◽  
Peter W. J. Rigby
Keyword(s):  
T Antigen ◽  
Large T Antigen ◽  
Sv40 Large T Antigen ◽  
Antigen Gene

Inhibition of proliferation and expression of T-antigen in SV40 large T-antigen gene-induced immortalized cells following transplantations

1997 ◽  
Vol 113 (1-2) ◽  
pp. 55-60 ◽  
Author(s):  
Francisco G. La Rosa ◽  
Frank S. Adams ◽  
Gregory E. Krause ◽  
Arlen D. Meyers ◽  
Judith Edwards-Prasad ◽  
...  
Keyword(s):  
T Antigen ◽  
Large T Antigen ◽  
Sv40 Large T Antigen ◽  
Inhibition Of Proliferation ◽  
Antigen Gene ◽  
Immortalized Cells
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