scholarly journals DD-03 * THE NATURALLY OCCURRING STEROID, WITHAFERIN A, IN SYNERGISTIC CONCERT WITH HER2/EGFR INHIBITORS ABROGATES PROLIFERATION OF HUMAN GLIOBLASTOMA CELL CULTURES AT NANOMOLAR CONCENTRATIONS

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v60-v60
Author(s):  
E. Chang ◽  
T. Abbasi ◽  
A. D'Souza ◽  
G. Gowrishankar ◽  
P. Mallick ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Egfr Inhibitors ◽  
Withaferin A ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Naturally Occurring

Determination of the Lethal Dose of Dexamethasone for Early Passage In Vitro Human Glioblastoma Cell Cultures

Neurosurgery ◽  
1993 ◽  
Vol 33 (3) ◽  
pp. 485-488 ◽  
Author(s):  
Robert J. Maciunas ◽  
Robert A. Mericle ◽  
Christopher L. Sneed ◽  
Deborah J. Hefner ◽  
Patricia A. Commers ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Lethal Dose ◽  
Glioblastoma Cell ◽  
Early Passage ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell

Determination of the Lethal Dose of Dexamethasone for Early Passage In Vitro Human Glioblastoma Cell Cultures

Neurosurgery ◽  
1993 ◽  
Vol 33 (3) ◽  
pp. 485-488 ◽  
Author(s):  
Robert J. Maciunas ◽  
Robert A. Mericle ◽  
Christopher L. Sneed ◽  
Deborah J. Hefner ◽  
Patricia A. Commers ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Lethal Dose ◽  
Glioblastoma Cell ◽  
Early Passage ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell

FOTEMUSTINE EFFECT ON HUMAN GLIOBLASTOMA CELL LINES

Tsitologiya ◽  
2018 ◽  
Vol 60 (1) ◽  
Author(s):  
L. N. Kiseleva ◽  
◽  
A. V. Kartashev ◽  
N. L. Vartanyan ◽  
A. A. Pinevich ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Glioblastoma Cell Lines

scholarly journals Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle

2021 ◽  
Vol 22 (11) ◽  
pp. 5557
Author(s):  
Tao-Chieh Yang ◽  
Shih-Jung Liu ◽  
Wei-Lun Lo ◽  
Shu-Mei Chen ◽  
Ya-Ling Tang ◽  
...  
Keyword(s):  
Cell Line ◽  
Therapeutic Index ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell ◽  
Therapeutic Benefits ◽  
Biodegradable Poly ◽  
Anti Tumor Activity

Glioblastoma multiforme (GBM) has remained one of the most lethal and challenging cancers to treat. Previous studies have shown encouraging results when irinotecan was used in combination with temozolomide (TMZ) for treating GBM. However, irinotecan has a narrow therapeutic index: a slight dose increase in irinotecan can induce toxicities that outweigh its therapeutic benefits. SN-38 is the active metabolite of irinotecan that accounts for both its anti-tumor efficacy and toxicity. In our previous paper, we showed that SN-38 embedded into 50:50 biodegradable poly[(d,l)-lactide-co-glycolide] (PLGA) microparticles (SMPs) provides an efficient delivery and sustained release of SN-38 from SMPs in the brain tissues of rats. These properties of SMPs give them potential for therapeutic application due to their high efficacy and low toxicity. In this study, we tested the anti-tumor activity of SMP-based interstitial chemotherapy combined with TMZ using TMZ-resistant human glioblastoma cell line-derived xenograft models. Our data suggest that treatment in which SMPs are combined with TMZ reduces tumor growth and extends survival in mice bearing xenograft tumors derived from both TMZ-resistant and TMZ-sensitive human glioblastoma cell lines. Our findings demonstrate that combining SMPs with TMZ may have potential as a promising strategy for the treatment of GBM.

scholarly journals Differential response of human glioblastoma cell lines to combined camptothecin and ionizing radiation treatment

2008 ◽  
Vol 7 (3) ◽  
pp. 364-373 ◽  
Author(s):  
Cholpon S. Djuzenova ◽  
Teresa Güttler ◽  
Sabrina Berger ◽  
Astrid Katzer ◽  
Michael Flentje
Keyword(s):  
Ionizing Radiation ◽  
Cell Lines ◽  
Radiation Treatment ◽  
Differential Response ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Glioblastoma Cell Lines
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