scholarly journals ME-10 * TUMOR MICROENVIRONMENT INFILTRATING MYELOID DERIVED SUPPRESSOR CELLS INHIBIT ANTI-TUMOR T CELL RESPONSES

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v121-v122
Author(s):  
N. Kamran ◽  
M. Ayala ◽  
Y. Li ◽  
H. Assi ◽  
M. Candolfi ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Microenvironment ◽  
Suppressor Cells ◽  
T Cell Responses ◽  
Myeloid Derived Suppressor Cells ◽  
Cell Responses

scholarly journals Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responses

2014 ◽  
Vol 44 (9) ◽  
pp. 2582-2591 ◽  
Author(s):  
Natascha Köstlin ◽  
Hellen Kugel ◽  
Bärbel Spring ◽  
Anja Leiber ◽  
Alexander Marmé ◽  
...  
Keyword(s):  
T Cell ◽  
Suppressor Cells ◽  
T Cell Responses ◽  
Myeloid Derived Suppressor Cells ◽  
Human Pregnancy ◽  
Cell Responses

Immature myeloid Gr-1+ CD11b+ cells from lipopolysaccharide-immunosuppressed mice acquire inhibitory activity in the bone marrow and migrate to lymph nodes to exert their suppressive function

2016 ◽  
Vol 130 (4) ◽  
pp. 259-271 ◽  
Author(s):  
Veronica I. Landoni ◽  
Daiana Martire-Greco ◽  
Nahuel Rodriguez-Rodrigues ◽  
Paula Chiarella ◽  
Pablo Schierloh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Lymph Nodes ◽  
Inhibitory Activity ◽  
Suppressor Cells ◽  
T Cell Responses ◽  
Myeloid Derived Suppressor Cells ◽  
Suppressive Function ◽  
Cell Responses ◽  
Immunosuppressed Mice

LPS-induced immunosuppression, mimicking the state observed in patients with late sepsis, induced in bone marrow a population of myeloid-derived suppressor cells (Gr-1+ CD11b+) with the ability to inhibit T-cell responses and migrate to lymph nodes to exert their suppressive function.

Abstract 457: Depletion of glioma infiltrating myeloid derived suppressor cells promotes anti-tumor T cell responses

2015 ◽  
Author(s):  
Neha Kamran ◽  
Youping Li ◽  
Mariela Moreno-Ayala ◽  
Hikmat Assi ◽  
Marianela Candolfi ◽  
...  
Keyword(s):  
T Cell ◽  
Suppressor Cells ◽  
T Cell Responses ◽  
Myeloid Derived Suppressor Cells ◽  
Cell Responses

scholarly journals l-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

2014 ◽  
Vol 75 (2) ◽  
pp. 275-283 ◽  
Author(s):  
Matthew Fletcher ◽  
Maria E. Ramirez ◽  
Rosa A. Sierra ◽  
Patrick Raber ◽  
Paul Thevenot ◽  
...  
Keyword(s):  
T Cell ◽  
Suppressor Cells ◽  
T Cell Responses ◽  
Myeloid Derived Suppressor Cells ◽  
Cell Responses

scholarly journals CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs

Blood ◽  
2014 ◽  
Vol 124 (5) ◽  
pp. 750-760 ◽  
Author(s):  
Regina Jitschin ◽  
Martina Braun ◽  
Maike Büttner ◽  
Katja Dettmer-Wilde ◽  
Juliane Bricks ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Suppressor Cells ◽  
T Cell Responses ◽  
Myeloid Derived Suppressor Cells ◽  
Cell Responses ◽  
Key Points

Key Points Monocytic IDOhi MDSCs are increased in CLL patients, suppress T cells, and promote TReg induction. CLL cells induce conversion of monocytes into MDSCs suggesting bidirectional crosstalk between CLL cells, MDSCs, and TRegs.

scholarly journals Myeloid-Derived Suppressor Cells (MDSCs) in Haematology

2021 ◽  
Vol 11 (1) ◽  
pp. 187
Author(s):  
Nikoleta Bizymi ◽  
Helen A. Papadaki
Keyword(s):  
T Cell ◽  
Myeloid Cells ◽  
Suppressor Cells ◽  
T Cell Responses ◽  
Myeloid Derived Suppressor Cells ◽  
Cell Responses ◽  
Immature Myeloid Cells

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with immunomodulating properties, mainly acting by suppressing T-cell responses [...]

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