scholarly journals Multimodal MRI features predict isocitrate dehydrogenase genotype in high-grade gliomas

2016 ◽  
Vol 19 (1) ◽  
pp. 109-117 ◽  
Author(s):  
Biqi Zhang ◽  
Ken Chang ◽  
Shakti Ramkissoon ◽  
Shyam Tanguturi ◽  
Wenya Linda Bi ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
High Grade ◽  
Mri Features ◽  
Multimodal Mri ◽  
High Grade Gliomas

scholarly journals Machine learning reveals multimodal MRI patterns predictive of isocitrate dehydrogenase and 1p/19q status in diffuse low- and high-grade gliomas

2019 ◽  
Vol 142 (2) ◽  
pp. 299-307 ◽  
Author(s):  
Hao Zhou ◽  
Ken Chang ◽  
Harrison X. Bai ◽  
Bo Xiao ◽  
Chang Su ◽  
...  
Keyword(s):  
Machine Learning ◽  
Isocitrate Dehydrogenase ◽  
High Grade ◽  
Multimodal Mri ◽  
High Grade Gliomas

scholarly journals T2 mapping of the peritumoral infiltration zone of glioblastoma and anaplastic astrocytoma

2021 ◽  
pp. 197140092198932
Author(s):  
Timo Alexander Auer ◽  
Maike Kern ◽  
Uli Fehrenbach ◽  
Yasemin Tanyldizi ◽  
Martin Misch ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Isocitrate Dehydrogenase ◽  
Anaplastic Astrocytoma ◽  
T2 Mapping ◽  
Relaxation Times ◽  
Region Of Interest ◽  
World Health ◽  
High Grade ◽  
High Grade Gliomas ◽  
Health Organization

Purpose To characterise peritumoral zones in glioblastoma and anaplastic astrocytoma evaluating T2 values using T2 mapping sequences. Materials and methods In this study, 41 patients with histopathologically confirmed World Health Organization high grade gliomas and preoperative magnetic resonance imaging examinations were retrospectively identified and enrolled. High grade gliomas were differentiated: (a) by grade, glioblastoma versus anaplastic astrocytoma; and (b) by isocitrate dehydrogenase mutational state, mutated versus wildtype. T2 map relaxation times were assessed from the tumour centre to peritumoral zones by means of a region of interest and calculated pixelwise by using a fit model. Results Significant differences between T2 values evaluated from the tumour centre to the peritumoral zone were found between glioblastoma and anaplastic astrocytoma, showing a higher decrease in signal intensity (T2 value) from tumour centre to periphery for glioblastoma ( P = 0.0049 – fit-model: glioblastoma –25.02± 19.89 (–54–10); anaplastic astrocytoma –5.57±22.94 (–51–47)). Similar results were found when the cohort was subdivided by their isocitrate dehydrogenase profile, showing an increased drawdown from tumour centre to periphery for wildtype in comparison to mutated isocitrate dehydrogenase ( P = 0.0430 – fit model: isocitrate dehydrogenase wildtype –10.35±16.20 (–51) – 0; isocitrate dehydrogenase mutated 12.14±21.24 (–15–47)). A strong statistical proof for both subgroup analyses ( P = 0.9987 – glioblastoma R2 0.93±0.08; anaplastic astrocytoma R2 0.94±0.15) was found. Conclusion Peritumoral T2 mapping relaxation time tissue behaviour of glioblastoma differs from anaplastic astrocytoma. Significant differences in T2 values, using T2 mapping relaxation time, were found between glioblastoma and anaplastic astrocytoma, capturing the tumour centre to the peritumoral zone. A similar curve progression from tumour centre to peritumoral zone was found for isocitrate dehydrogenase wildtype high grade gliomas in comparison to isocitrate dehydrogenase mutated high grade gliomas. This finding is in accordance with the biologically more aggressive behaviour of isocitrate dehydrogenase wildtype in comparison to isocitrate dehydrogenase mutated high grade gliomas. These results emphasize the potential of mapping techniques to reflect the tissue composition of high grade gliomas.

scholarly journals Assessment of Isocitrate Dehydrogenase 1 Mutation by Immunohistochemistry in Egyptian Patients with High-grade Gliomas

2021 ◽  
Vol 9 (A) ◽  
pp. 157-163
Author(s):  
Essam Ayad ◽  
Sylvia Mikhael Ghattas ◽  
Rabab Abdel Moneim ◽  
Azzam Ismail ◽  
Rasha A. Khairy
Keyword(s):  
Significant Relationship ◽  
Isocitrate Dehydrogenase ◽  
Progression Free Survival ◽  
High Grade Glioma ◽  
Idh1 Mutation ◽  
Response To Treatment ◽  
High Grade ◽  
Isocitrate Dehydrogenase 1 ◽  
High Grade Gliomas ◽  
Grade Iii

BACKGROUND: At present, the classification of central nervous system tumors relies on molecular factors in addition to histologic features to identify many tumor types. This should subsequently results in more accurate diagnosis as well as addressing specific markers of potential prognostic and predictive value. AIM: This study was conducted to emphasize the importance of including isocitrate dehydrogenase 1 (IDH1) evaluation as a crucial part of the diagnosis and categorization of high-grade glioma cases. This also may help to individualize the treatment of high-grade glioma patients. MATERIALS AND METHODS: The current study included 60 cases of high-grade gliomas, studied histologically and immunohistochemically for the detection of IDH1 mutation. The results were correlated with different clinicopathologic variables and course of the disease. RESULTS: IDH1 immunohistochemical expression was positive in 46.67% of the studied high-grade glioma cases. A statistically significant relationship was detected between IDH1 expression and tumor histologic grade as 100% of Grade III anaplastic oligodendroglioma cases and 80% of the Grade III anaplastic astrocytoma cases were IDH1 positive while only 40.4% of Grade IV glioblastoma cases were IDH1 positive (p = 0.03). In addition, patients who were IDH1 mutant were in a better category of response to radiotherapy (p = 0.019) and also to chemotherapy (p < 0.001). Moreover, patients who expressed IDH1 had prolonged overall survival (OS) and progression-free survival than those who showed negative IDH1expression (p < 0.001). On the other hand, no statistically significant relationship was detected between IDH1 expression and patients age, sex, tumor site, tumor size, motor symptoms, sensory symptoms, and increased intracranial tension (p > 0.05). CONCLUSIONS: It is suggested that IDH1 is a good prognostic marker for gliomas and is a good predictive marker for response to treatment. IDH1 is a promising target for therapy in high-grade gliomas through the emerging IDH1 inhibitors. Immunohistochemical testing for IDH1 is a practical and cost-effective method that should be applied in all glioma cases. Further study on a larger sample size is recommended to validate the current results. Moreover, applying molecular analysis to detect IDH1 mutation is recommended to be able to precisely detect the IDH1 wild-type tumor

Effectiveness of Stereotactic Radiotherapy and Bevacizumab for Recurrent High-Grade Gliomas: A Potential Therapy for Isocitrate Dehydrogenase Wild-Type Recurrent High-Grade Gliomas

2018 ◽  
Vol 114 ◽  
pp. e1138-e1146
Author(s):  
Takayuki Yasuda ◽  
Yoshihiro Muragaki ◽  
Masayuki Nitta ◽  
Kazunari Miyamoto ◽  
Yuko Oura ◽  
...  
Keyword(s):  
Stereotactic Radiotherapy ◽  
Isocitrate Dehydrogenase ◽  
High Grade ◽  
Wild Type ◽  
High Grade Gliomas

High‐grade gliomas with isocitrate dehydrogenase wild‐type and 1p/19q codeleted: Atypical molecular phenotype and current challenges in molecular diagnosis

2020 ◽  
Vol 40 (6) ◽  
pp. 599-605
Author(s):  
Linmao Zheng ◽  
Mengni Zhang ◽  
Jing Hou ◽  
Jing Gong ◽  
Ling Nie ◽  
...  
Keyword(s):  
Molecular Diagnosis ◽  
Isocitrate Dehydrogenase ◽  
High Grade ◽  
Wild Type ◽  
Molecular Phenotype ◽  
High Grade Gliomas

scholarly journals Influence of scalp block on oncological outcomes of high-grade glioma in adult patients with and without isocitrate dehydrogenase-1 mutation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chao-Hsien Sung ◽  
Fon-Yih Tsuang ◽  
Chih-Peng Lin ◽  
Kuang-Cheng Chan ◽  
Wei-Han Chou ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Isocitrate Dehydrogenase ◽  
Tumor Resection ◽  
High Grade Glioma ◽  
Hazard Ratio ◽  
High Grade ◽  
Isocitrate Dehydrogenase 1 ◽  
Cox Regression Analysis ◽  
Scalp Block ◽  
High Grade Gliomas

AbstractHigh-grade gliomas are notorious for a high recurrence rate even after curative resection surgery. Studies regarding the influence of scalp block on high-grade gliomas have been inconclusive, possibly because the condition’s most important genetic mutation profile, namely the isocitrate dehydrogenase 1 (IDH1) mutation, had not been analyzed. Therefore, we conducted a single-center study including patients with high-grade glioma who underwent tumor resection between January 2014 and December 2019. Kaplan–Meier survival analysis revealed that scalp block was associated with longer progression-free survival (PFS; 15.17 vs. 10.77 months, p = 0.0018), as was the IDH1 mutation (37.37 vs. 10.90 months, p = 0.0149). Multivariate Cox regression analysis revealed that scalp block (hazard ratio: 0.436, 95% confidence interval: 0.236–0.807, p = 0.0082), gross total resection (hazard ratio: 0.405, 95% confidence interval: 0.227–0.721, p = 0.0021), and IDH1 mutation (hazard ratio: 0.304, 95% confidence interval: 0.118–0.784, p = 0.0138) were associated with better PFS. Our results demonstrate that application of scalp block, regardless of IDH1 profile, is an independent factor associated with longer PFS for patients with high-grade glioma.

scholarly journals Comparison of Genetic Profiles and Prognosis of High-Grade Gliomas Using Quantitative and Qualitative MRI Features: A Focus on G3 Gliomas

2021 ◽  
Vol 22 (2) ◽  
pp. 233
Author(s):  
Eun Kyoung Hong ◽  
Seung Hong Choi ◽  
Dong Jae Shin ◽  
Sang Won Jo ◽  
Roh-Eul Yoo ◽  
...  
Keyword(s):  
High Grade ◽  
Mri Features ◽  
High Grade Gliomas ◽  
Genetic Profiles

Illustration of the Added Value of 18F-DOPA PET to Multimodal MRI to Distinguish Low- and High-Grade Gliomas

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Nicolas Louarn ◽  
Paul Kauv ◽  
Laurent Capelle ◽  
Karima Mokhtari ◽  
Emmanuel Itti
Keyword(s):  
Added Value ◽  
High Grade ◽  
Multimodal Mri ◽  
High Grade Gliomas
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