scholarly journals EXTH-47. DEVELOPMENT OF A NOVEL FLUORESCENT VIRUS-LIKE-PARTICLES AS RNA INTERFERENCE AND TUMOR SUPPRESSOR GENE DELIVERY TOOL FOR BRAIN TUMOR TREATMENT

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi95-vi95
Author(s):  
Chiungyin Huang ◽  
Kuo-Chen Wei
Keyword(s):  
Brain Tumor ◽  
Rna Interference ◽  
Tumor Suppressor ◽  
Gene Delivery ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Tumor Treatment ◽  
Virus Like Particles

scholarly journals NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

2015 ◽  
Vol 112 (37) ◽  
pp. 11583-11588 ◽  
Author(s):  
Sarah Croessmann ◽  
Hong Yuen Wong ◽  
Daniel J. Zabransky ◽  
David Chu ◽  
Janet Mendonca ◽  
...  
Keyword(s):  
Rna Interference ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Genomic Instability ◽  
Genome Stability ◽  
Suppressor Gene ◽  
Wild Type ◽  
Human Cancers ◽  
Altered Gene ◽  
Interference Studies

The tumor protein 53 (TP53) tumor suppressor gene is the most frequently somatically altered gene in human cancers. Here we show expression of N-Myc down-regulated gene 1 (NDRG1) is induced by p53 during physiologic low proliferative states, and mediates centrosome homeostasis, thus maintaining genome stability. When placed in physiologic low-proliferating conditions, human TP53 null cells fail to increase expression of NDRG1 compared with isogenic wild-type controls and TP53 R248W knockin cells. Overexpression and RNA interference studies demonstrate that NDRG1 regulates centrosome number and amplification. Mechanistically, NDRG1 physically associates with γ-tubulin, a key component of the centrosome, with reduced association in p53 null cells. Strikingly, TP53 homozygous loss was mutually exclusive of NDRG1 overexpression in over 96% of human cancers, supporting the broad applicability of these results. Our study elucidates a mechanism of how TP53 loss leads to abnormal centrosome numbers and genomic instability mediated by NDRG1.

Cloning, sequence, and developmental expression analysis of C4-2, a potential brain tumor-suppressor gene

1997 ◽  
Vol 65 (4) ◽  
pp. 249-257 ◽  
Author(s):  
Anil Sehgal ◽  
Sherianne Ricks ◽  
Cassie Keener ◽  
Alton L. Boynton ◽  
Ronald F. Young ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Expression Analysis ◽  
Suppressor Gene ◽  
Developmental Expression

Possible Role of The Tumor Suppressor Gene Retinoblastoma (Rb1) In Human Brain Tumor Development

2007 ◽  
Vol 14 (3) ◽  
pp. 72-82 ◽  
Author(s):  
Mathivanan Jothi ◽  
Rohini Keshava ◽  
Mohan L Gope ◽  
Rajalakshmi Gope
Keyword(s):  
Brain Tumor ◽  
Tumor Suppressor ◽  
Human Brain ◽  
Tumor Suppressor Gene ◽  
Tumor Development ◽  
Suppressor Gene ◽  
Human Brain Tumor

Dynamic Tracking of p21 mRNA in Living Cells by Sticky-Flares for Visual Evaluation of Tumor Treatment Effect

Nanoscale ◽  
2021 ◽  
Author(s):  
Tingting Zhao ◽  
Fengqi Dong ◽  
Xinlong Hu ◽  
Yanli Xu ◽  
Wen-mei Wei ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Treatment Effect ◽  
Suppressor Gene ◽  
Living Cells ◽  
Expression Level ◽  
Tumor Treatment ◽  
Visual Evaluation ◽  
Dynamic Tracking

Monitoring the expression level of intracellular tumor suppressor gene of p21 mRNA is essential to reveal the progress and prognosis of tumor. Methods widely reported for the detection of p21...

CENP-C: An oncogene or tumor suppressor gene? A possible new tumor marker

2001 ◽  
Vol 120 (5) ◽  
pp. A299-A299
Author(s):  
D KAZANOV ◽  
B STERN ◽  
W PYERIN ◽  
O BOECHER ◽  
H STRUL ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Marker ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene
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