The Ruptured Arteriovenous Malformation Grading Scale (RAGS): An Extension of the Hunt and Hess Scale to Predict Clinical Outcome for Patients With Ruptured Brain Arteriovenous Malformations

Neurosurgery ◽  
2019 ◽  
Vol 87 (2) ◽  
pp. 193-199 ◽  
Author(s):  
Michael A Silva ◽  
Pui Man Rosalind Lai ◽  
Rose Du ◽  
Mohammad A Aziz-Sultan ◽  
Nirav J Patel
Keyword(s):  
Clinical Outcome ◽  
Arteriovenous Malformation ◽  
Venous Drainage ◽  
Receiver Operating Curve ◽  
Simple Extension ◽  
Grading Systems ◽  
Ruptured Avm ◽  
Grading Scale ◽  
Ordinal Logistic Regression Model

Abstract BACKGROUND Arteriovenous malformation (AVM) rupture is highly morbid. Outcomes after AVM rupture differ from other types of brain hemorrhage. There are no specific widely used grading systems designed to predict clinical outcome after AVM rupture. OBJECTIVE To develop an all-comers scoring system to grade patients with AVM rupture and predict clinical outcome more accurately than grading systems currently in use. METHODS We retrospectively reviewed patients who presented to our institution with a ruptured AVM. Using change in modified Rankin Score (mRS) as our response variable, we generated an ordinal logistic regression model to test for significant predictor variables. The full model was sequentially condensed until the simplest model with the highest area under the receiver operating curve (AUROC) was achieved. RESULTS A total of 115 patients who presented with ruptured AVMs were included in the study, with a mean follow-up time of 4 yr. The Ruptured AVM Grading Scale (RAGS) consists of the Hunt and Hess (HH) score (1-5), patient age (<35 = 0, 35-70 = 1, and >70 = 2), deep venous drainage (1), and eloquence (1). The RAGS score outperformed other neurosurgical grading scales in predicting change in mRS, with an AUROC greater than 0.80 across all follow-up periods. CONCLUSION The RAGS score is a simple extension of the HH scale that predicts clinical outcome after AVM rupture more accurately than other grading systems.

Abstract MP7: Multicenter Study of Intracranial Hemorrhage and Death Risk and Predictors in the Untreated Course of Brain Arteriovenous Malformation Patients

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Helen Kim ◽  
Jeffrey Nelson ◽  
Charles McCulloch ◽  
Steven Hetts ◽  
Christopher Hess ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arteriovenous Malformation ◽  
Intracranial Hemorrhage ◽  
Cox Regression ◽  
Current Model ◽  
Venous Drainage ◽  
Age At Diagnosis ◽  
Imaging Data ◽  
Brain Arteriovenous Malformation

Background: Accurate and reliable models of intracranial hemorrhage (ICH) risk in the untreated course of brain arteriovenous malformation (BAVM) patients are needed to help weigh the risk-benefit of treatment. We present preliminary estimates of rates and risk factors for ICH or death in the Multicenter AVM Research Study (MARS), which is the largest individual patient data meta-analysis (IPDMA) of cohort studies of unruptured BAVM. Methods: Longitudinal data from 9 cohorts comprising 2,839 unruptured BAVM at time of diagnosis were included: UCSF (n=557), Macquarie (n=462), Kaiser Permanente Northern California (n=354), Columbia (n=335), Barrow Neurological Institute (n=324), Tiantan Hospital (n=303), Mayo Clinic-Rochester (n=244), Scottish Intracranial Vascular Malformation Study (n=194), and Toronto Western Hospital (n=66). Clinical and angiographic data were collected using standardized definitions across cohorts. Cox proportional hazards analysis of time-to-event (ICH or death) in the untreated course after diagnosis was performed, censoring at first treatment or last visit. Baseline hazard rates were stratified by cohort to account for different rates and follow-up times. Results: The combined cohort was 49% female, 72% white race, and 17% Hispanic ethnicity; mean age at diagnosis was 37±17 years and mean follow-up was 3.4±7.0 years. The most common presenting symptom was seizures (43%). Mean AVM size was 3.5±1.9 cm and 46% were Spetzler-Martin grade I-II. Overall, 123 ICH and 131 deaths occurred over 9,608 person-years (PY) for an event rate of 2.64 per 100 PY [95% CI: 2.34-2.99]. Cox regression analyses adjusting for age at diagnosis (HR=1.67 [1.54, 1.82], P<0.001) identified cerebellar location (HR=1.73 [1.03-2.93], P=0.040) and exclusively deep venous drainage (HR=1.83 [1.09-3.09], P=0.022) as predictors. Conclusion: Our current model identified increasing age, exclusively deep venous drainage, and cerebellar location as risk factors for ICH or death in the untreated course of unruptured bAVM patients. Review of imaging data, multiple imputation of missing angioarchitectural data, and additional data from pending cohorts will provide greater power to search for additional risk factors in this ongoing IPDMA.

scholarly journals Comparative study between single versus double burr-hole drainage of unilateral chronic subdural haematoma

2014 ◽  
Vol 43 (1) ◽  
pp. 13-16 ◽  
Author(s):  
SM Asaduzzaman ◽  
KM Tarikul Islam ◽  
Mohammad Nazrul Hossain ◽  
Md Ruhul Amin ◽  
Md Jahangir Alam ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Subdural Haematoma ◽  
The Elderly ◽  
Chronic Subdural Haematoma ◽  
Burr Hole ◽  
Limb Weakness ◽  
Group A ◽  
Grading Scale ◽  
Group B

Chronic subdural haematoma (CSDH) is defined as the haematoma in the subdural space which tend to occur in the elderly several weeks after head injury. The incidence of CSDH varied from 1.72 per 100,000 inhabitants per year in Finland to 13.1 per 100,000 inhabitants per year in Japan with a peak incidence in the sixth and seventh decade of life. CSDH is a common treatable cause of dementia. The principal techniques used in the treatment of CSDHs are presently burr hole, twist drill craniostomy, craniectomy and craniotomy. The aim of this study was to assess clinical outcome in unilateral chronic subdural haematoma psatients treated by single or double burr-hole drainage. This clinical trial was carried out at the department of neurosurgery, BSMMU from June 2010 to November 2011. A total of 40 consecutive patients with their age ranged from 50 to 70 years with GCS 9 to 13 & haematoma volume greater than 30cc were included in this study and randomly divided into two groups. In group A, patients with chronic subdural haematoma (CSDH) were managed with double burr-hole drainage. In group B, patients were managed with single burr-hole drainage. Clinical outcome was measured on the 1st post operative day, 3rd post operative day and at the time of discharge (usually on the 7th post operative day) and at 1 month follow-up by measuring Glassgow coma scale (GCS), improvement of limb weakness and Markwalder grading scale. In this study double burr-hole drainage and single burr-hole drainage surgery shows equal success in the management of CSDHs. DOI: http://dx.doi.org/10.3329/bmj.v43i1.21370 Bangladesh Med J. 2014 January; 43 (1): 13-16

scholarly journals A Grading System for Intracranial Arteriovenous Malformations Applicable to Endovascular Procedures

2000 ◽  
Vol 6 (1_suppl) ◽  
pp. 139-142 ◽  
Author(s):  
B. Sheikh ◽  
I. Nakahara ◽  
A. El-Naggar ◽  
I. Nagata ◽  
H. Kikuchi
Keyword(s):  
Arteriovenous Malformation ◽  
Endovascular Procedures ◽  
Drainage System ◽  
Venous Drainage ◽  
Endovascular Embolization ◽  
Point Of View ◽  
Grading System ◽  
Intracranial Arteriovenous Malformations ◽  
Intracranial Arteriovenous Malformation ◽  
Grading Systems

A grading system was designed by the first author (B.S.) specifically to predict the difficulty of endovascular obliteration of an intracranial arteriovenous malformation based on the feeding arterial characteristics, and the venous drainage system. We have retrospectively reviewed our cases of intracranial arteriovenous malformation, with special interest in those underwent endovascular embolization. The grading of the AVM was by either our new proposed system or by a surgically oriented grading system. Both systems were compared from the endovascular point of view. Using the present proposed grading system intracranial arteriovenous malformation may range from grade I to grade V. The difficulty of the endovascular embolization correlated well with the new grading system, while in most cases it did not reflect the degree of difficulty of the procedure when a pure surgical grading system was used. This newly designed grading system has a better prediction value to the difficulty of performing endovascular embolization than does other grading systems.

International multicentre validation of the arteriovenous malformation-related intracerebral haemorrhage (AVICH) score

2017 ◽  
Vol 89 (11) ◽  
pp. 1163-1166 ◽  
Author(s):  
Marian C. Neidert ◽  
Michael T. Lawton ◽  
Louis J. Kim ◽  
John D. Nerva ◽  
Kaoru Kurisu ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Arteriovenous Malformation ◽  
Intracerebral Haemorrhage ◽  
Outcome Prediction ◽  
Univariate Analysis ◽  
External Validation ◽  
Registration Number ◽  
Predictive Outcome ◽  
Ich Score

ObjectiveThe recently published arteriovenous malformation-related intracerebral haemorrhage (AVICH) score showed better outcome prediction for patients with arteriovenous malformation (AVM)-related intracerebral haemorrhage (ICH) than other AVM or ICH scores. Here we present the results of a multicentre, external validation of the AVICH score.MethodsAll participating centres (n=11) provided anonymous data on 325 patients to form the Spetzler-Martin (SM) grade, the supplemented SM (sSM) grade, the ICH score and the AVICH score. Modified Rankin score (mRS) at last follow-up (mean 25.6 months) was dichotomized into favourable (mRS 0-2, n=210) and unfavourable (mRS 3-6;n=115). Univariate and AUROC analyses were performed to validate the AVICH score.ResultsExcept nidus structure and AVM size, all single parameters forming the SM, sSM, ICH and AVICH score and the scores itself were significantly different between both outcome groups in the univariate analysis. The AVICH score was confirmed to be the highest predictive outcome score with an AUROC of 0.765 compared with 0.705 for the ICH score and 0.682 for the sSM grade.ConclusionThe multicentre-validated AVICH score predicts clinical outcome superior to pre-existing scores. We suggest the routine use of this score for future clinical outcome prediction and in clinical research.Trial registration numberNCT02920645.

scholarly journals Does eloquence subtype influence outcome following arteriovenous malformation surgery?

2019 ◽  
Vol 131 (3) ◽  
pp. 876-883 ◽  
Author(s):  
Justin R. Mascitelli ◽  
Seungwon Yoon ◽  
Tyler S. Cole ◽  
Helen Kim ◽  
Michael T. Lawton
Keyword(s):  
Arteriovenous Malformation ◽  
Clinical Status ◽  
Venous Drainage ◽  
Motor Mapping ◽  
Poor Outcome ◽  
Significant Difference ◽  
Poor Outcomes ◽  
Average Size ◽  
Brain Avms

OBJECTIVEAlthough numerous arteriovenous malformation (AVM) grading scales consider eloquence in risk assessment, none differentiate the types of eloquence. The purpose of this study was to determine if eloquence subtype affects clinical outcome.METHODSThis is a retrospective review of a prospectively collected clinical database of brain AVMs treated with microsurgery in the period from 1997 to 2017. The only inclusion criterion for this study was the presence of eloquence as defined by the Spetzler-Martin grading scale. Eloquence was preoperatively categorized by radiologists. Poor outcome was defined as a modified Rankin Scale (mRS) score 3–6, and worsening clinical status was defined as an increase in the mRS score at follow-up. Logistic regression analyses were performed.RESULTSTwo hundred forty-one patients (49.4% female; average age 33.9 years) with eloquent brain AVMs were included in this review. Of the AVMs (average size 2.7 cm), 54.4% presented with hemorrhage, 46.2% had deep venous drainage, and 17.0% were diffuse. The most common eloquence type was sensorimotor (46.1%), followed by visual (27.0%) and language (22.0%). Treatments included microsurgery alone (32.8%), microsurgery plus embolization (51.9%), microsurgery plus radiosurgery (7.9%), and all three modalities (7.5%). Motor mapping was used in 9% of sensorimotor AVM cases, and awake speech mapping was used in 13.2% of AVMs with language eloquence. Complications occurred in 24 patients (10%). At the last follow-up (average 24 months), 71.4% of the patients were unchanged or improved and 16.6% had a poor outcome. There was no statistically significant difference in the baseline patient and AVM characteristics among the different subtypes of eloquence. In a multivariate analysis, in comparison to visual eloquence, both sensorimotor (OR 7.4, p = 0.004) and language (OR 6.5, p = 0.015) eloquence were associated with poor outcomes. Additionally, older age (OR 1.31, p = 0.016) and larger AVM size (OR 1.37, p = 0.034) were associated with poor outcomes.CONCLUSIONSUnlike visual eloquence, sensorimotor and language eloquence were associated with worse clinical outcomes after the resection of eloquent AVMs. This nuance in AVM eloquence demands consideration before deciding on microsurgical intervention, especially when numerical grading systems produce a score near the borderline between operative and nonoperative management.

scholarly journals Dural arteriovenous fistulas with direct cortical venous drainage treated with Onyx®: a case series

2010 ◽  
Vol 68 (4) ◽  
pp. 613-618 ◽  
Author(s):  
Felipe Padovani Trivelato ◽  
Daniel Giansante Abud ◽  
Alexandre Cordeiro Ulhôa ◽  
Tiago de Jesus Menezes ◽  
Thiago Giansante Abud ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Transarterial Embolization ◽  
Case Series ◽  
Venous Drainage ◽  
Complete Occlusion ◽  
Arteriovenous Fistulas ◽  
Type Iv ◽  
Dural Arteriovenous Fistulas ◽  
Cortical Venous Drainage

Dural arteriovenous fistulas (DAVFs) may have aggressive symptoms, especially if there is direct cortical venous drainage. We report our preliminary experience in transarterial embolization of DAVFs with direct cortical venous drainage (CVR) using Onyx®. METHOD: Nine patients with DAVFs with direct cortical venous drainage were treated: eight type IV and one type III (Cognard). Treatment consisted of transarterial embolization using Onyx-18®. Immediate post treatment angiographies, clinical outcome and late follow-up angiographies were studied. RESULTS: Complete occlusion of the fistula was achieved in all patients with only one procedure and injection in only one arterial pedicle. On follow-up, eight patients became free from symptoms, one improved and no one deteriorated. Late angiographies showed no evidence of recurrent DAVF. CONCLUSION: We recommend that transarterial Onyx® embolization of DAVFs with direct cortical venous drainage be considered as a treatment option, while it showed to be feasible, safe and effective.

scholarly journals Time resolved computed tomography angiography in the evaluation of brain arteriovenous malformation: a feasibility study

2017 ◽  
Vol 31 (3) ◽  
pp. 230-234 ◽  
Author(s):  
Rupinder Singh ◽  
Vivek Gupta ◽  
Chirag Ahuja ◽  
Niranjan Khandelwal
Keyword(s):  
Computed Tomography ◽  
Arteriovenous Malformation ◽  
Digital Subtraction Angiography ◽  
Computed Tomography Angiography ◽  
Venous Drainage ◽  
Complete Agreement ◽  
Digital Subtraction ◽  
Time Resolved ◽  
Non Invasive

Background and purpose Digital subtraction angiography is the current gold standard for diagnosing as well as the follow-up of cerebral arteriovenous malformations. However, as it is invasive, relatively expensive and time-consuming, a non-invasive alternative is of interest. We aimed to evaluate the feasibility of time resolved computed tomography angiography (TR-CTA) in a series of five diagnosed cranial arteriovenous malformation patients, demonstrated by conventional digital subtraction angiography with respect to acquisition, depiction of angiographic phases and radiation exposure. Materials and methods Five patients demonstrating a cranial arteriovenous malformation on digital subtraction angiography were studied with TR-CTA. The TR-CTA imaging was done by using a 128-detector computed tomography scanner. Digital subtraction angiography and TR-CTA studies were independently read by two blinded observers, by using a standardised scoring sheet. TR-CTA results were analysed with digital subtraction angiography as the criterion standard. Results TR-CTA generated comparable angiographic phases. In all five cases, there was complete agreement between digital subtraction angiography and TR-CTA regarding the size, arterial feeders, nidal morphology and venous drainage of the arteriovenous malformation. Conclusions TR-CTA imaging as a technique is feasible, providing images with good temporal and spatial resolution at an acceptable radiation dose. It appears to be a promising non-invasive adjunct to digital subtraction angiography.

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