scholarly journals COT-1 Clinical Questions and Answers about Glioma-Related Epilepsy (GRE): Real-world data in Wakayama Medical University Hospital

2021 ◽  
Vol 3 (Supplement_6) ◽  
pp. vi28-vi28
Author(s):  
Junya Fukai ◽  
Takahiro Sasaki ◽  
Toshikazu Yamoto ◽  
Yasuo Nakai ◽  
Masamichi Ishii ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Real World ◽  
University Hospital ◽  
Occurrence Rate ◽  
Diffuse Glioma ◽  
Real World Data ◽  
World Data ◽  
Molecular Features ◽  
Clinical Questions ◽  
Medical University

Abstract Introduction: In glioma patients, epilepsy not infrequently occurred and anti-epileptic drugs (AEDs) are commonly used. In this study, we revealed the real-world data on clinical practice of glioma-related epilepsy in Wakayama Medical University Hospital (WMUH). Methods. We collected clinical and molecular data of glioma patients operated at WMUH from January 1996 to December 2020 and analyzed the data to answer clinical questions as follows: 1) location/histology related GRE, 2) molecular features related GRE, 3) prophylactic AEDs and postoperative seizure, 4) tumor progression and convulsion, 5) GRE and survival. Results. Fifty-five of 113 glioma patients (49%) presented with seizure. CQ1. In tumors located at frontal, temporal and parietal lobe, the occurrence rate of GRE was 27/39 (69%), 13/19 (69%) and 9/14 (64%), respectively. Patients with glioblastoma, astrocytic tumors and oligodendroglial tumors presented with GRE at the rate of 26/54 (48%), 14/30 (47%) and 12/13 (92%), respectively. CQ2. GRE occurred in tumors with IDH mutated (16 cases, 29%), TERT mutated (32 cases, 58%) and MGMT methylated (32 cases, 58%). CQ3. Seizure in peri- or postoperative period occurred in 14 cases (12%); 4 cases in AED(+) group (4/29, 14%) and 10 cases in AED(-) group (10/84, 12%). CQ4. Tumor progression became apparent at the time of seizure in 12 cases (12/55, 22%). CQ5. According to the prognostic IDH/TERT classification of diffuse glioma cases (n = 94), overall survival (OS) times of GRE(+) cases tended to be longer than that of GRE(-) ones, especially in IDH wildtype/TERT mutated group (22.7 months vs. 8.3 months, p = 0.0397). Conclusion. GRE is likely associated with specific clinical and molecular features. Seizure in glioma patients can occur in specific situation regardless of the use of AEDs. Possible better prognosis of GRE(+) cases requires further investigation.

Abstract P3-14-05: Oncotype DX assay’s real world data in early stage breast cancer patients. Outcomes of a cohort treated in the Basurto University Hospital, Spain

2020 ◽  
Author(s):  
Maria Purificacion Martínez del Prado ◽  
Borja López de San Vicente ◽  
Juan Fernando Arango Arteaga ◽  
Jairo Legaspi Folgueira ◽  
Ane Zumárraga Cuesta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Real World ◽  
Early Stage ◽  
Oncotype Dx ◽  
Early Stage Breast Cancer ◽  
University Hospital ◽  
Breast Cancer Patients ◽  
Real World Data ◽  
World Data

scholarly journals Psoriasis care during the time of COVID-19: real-world data on changes in treatments and appointments from a German university hospital

2021 ◽  
Vol 31 (2) ◽  
pp. 183-191
Author(s):  
Nadia Ninosu ◽  
Fabio Roehrich ◽  
Katharina Diehl ◽  
Wiebke K. Peitsch ◽  
Marthe-Lisa Schaarschmidt
Keyword(s):  
Real World ◽  
University Hospital ◽  
Real World Data ◽  
World Data

scholarly journals Prolonged follow‐up on lenalidomide‐based treatment for mucosa‐associated lymphoid tissue lymphoma (MALT lymphoma)—Real‐world data from the Medical University of Vienna

2019 ◽  
Vol 37 (4) ◽  
pp. 345-351 ◽  
Author(s):  
Barbara Kiesewetter ◽  
Wolfgang Lamm ◽  
Ortrun Neuper ◽  
Marius E. Mayerhoefer ◽  
Ingrid Simonitsch‐Klupp ◽  
...  
Keyword(s):  
Malt Lymphoma ◽  
Real World ◽  
Lymphoid Tissue ◽  
Real World Data ◽  
World Data ◽  
University Of Vienna ◽  
Medical University

scholarly journals Positive Impact of Perioperative Oral Management on the Risk of Surgical Site Infections after Abdominal Surgery: A Analysis of Real-World Data from 16 University Hospitals in Japan

2021 ◽  
Author(s):  
Tetsu SHIMANE ◽  
Kazuyuki Koike ◽  
Shigeyuki Fujita ◽  
Hiroshi Kurita ◽  
Emiko Tanaka Isomura ◽  
...  
Keyword(s):  
Abdominal Surgery ◽  
Real World ◽  
Eastern Cooperative Oncology Group ◽  
Operation Time ◽  
Surgical Site Infections ◽  
University Hospital ◽  
University Hospitals ◽  
Real World Data ◽  
World Data ◽  
Asa Classification

Abstract Background: Surgical site infections (SSI) are associated with increased morbidity and mortality. The purpose of this study was to investigate the ability of perioperative oral management (POM) to reduce the risk of SSI in abdominal surgery. Real-world data collected from 16 Japanese university hospital was reviewed. Methods: The medical records of consecutive 2,782 patients (1,750 men and 1,032 women) who underwent abdominal surgery under general anesthesia in 16 university hospitals were retrospectively reviewed. Detailed information about SSI was assessed and compared between patients with and without POM in univariate and multivariate analyses. Results: SSI were observed in 275 patients (incidence rate: 9.9%) and POM was delivered in 778 patients (28.0%). Univariate analyses revealed that diabetes mellitus, Eastern Cooperative Oncology Group (ECOG) performance status, the American Society of Anesthesiologists (ASA) classification, the surgical site, the preoperative Prognostic Nutritional Index score, POM, the extent of surgery, the operation time, and the amount of intraoperative blood loss were significantly associated with postoperative SSI (Chi-square or Mann-Whitney U-test, p <0.01). The multivariate analysis revealed that POM had significant preventative effects against postoperative SSI (estimate: -0.245, standard error: 0.080, p <0.01). The surgical site, the ASA classification, and the operation time were also significant and independent clinical predictors of SSI.Conclusion: The analysis of real-world data from 16 university hospitals revealed that, regardless of the content and degree of the problem, addition of POM has significant beneficial effects in reducing the risk of SSI in patients who undergo abdominal surgery.

scholarly journals P475 Real world data on treatment success and drug persistence in anti-TNF therapy for ulcerative colitis

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S464-S465
Author(s):  
J A Lundekvam ◽  
M L Høivik ◽  
K Anisdahl ◽  
B Moum ◽  
A W Medhus
Keyword(s):  
Ulcerative Colitis ◽  
Real World ◽  
Treatment Success ◽  
Good Clinical Practice ◽  
Fecal Calprotectin ◽  
University Hospital ◽  
Biologic Agent ◽  
Real World Data ◽  
Serious Adverse Events ◽  
World Data

Abstract Background The efficacy and safety of anti-TNF treatment for ulcerative colitis (UC) have been well documented in clinical trials. More data are required to increase knowledge on treatment success in a real world setting. This study reports real world data on treatment success, drug persistence and safety of anti-TNF treatment in patients with UC. Methods Patients with UC starting anti-TNF treatment with infliximab (IFX) or adalimumab (ADA) between January 2014 and December 2019 at Oslo University Hospital in Norway were included in a retrospective review of medical records. Eligible patients were biologically naïve adults (≥18 years) with no history of UC-related surgery. Follow-up was 12 months. Drug persistence was defined as the proportion of patients still receiving first-line anti-TNF treatment without addition of a second biologic agent. Remission was defined as i) clinical remission (six-point Mayo Score &lt;2), ii) biochemical remission (fecal calprotectin &lt;250 and CRP &lt;5) or iii) a combination of the two. Treatment success was defined as drug persistence and remission. Serious adverse events (SAEs) were defined according to Good Clinical Practice guidelines. Results In total, 116 patients were included (mean age 35.5 ±13.9 years (SD), 58% male), of which 95 received IFX treatment and 21 ADA. Drug persistence was 74%. Treatment success by different definitions of remission and remission rates for drug persistent patients according to these definitions are reported in the table. SAEs were recorded on 18 occasions (four immediate infusion reactions, two colectomies, five infections and seven other events). Conclusion Treatment success by the strictest definition of remission was 40%. Of drug persistent patients, 44% were not in remission when applying the same definition. Whether these results reflect inadequacies in definitions of remission, a tendency for clinicians to let other variables guide treatment or a delay in drug switching warrants further investigation.

Abstract #946: Assessment of Acromegaly Patients with and Without Diabetes Treated with Lanreotide Depot: 2-Year Real World Data

2016 ◽  
Vol 22 ◽  
pp. 219
Author(s):  
Roberto Salvatori ◽  
Olga Gambetti ◽  
Whitney Woodmansee ◽  
David Cox ◽  
Beloo Mirakhur ◽  
...  
Keyword(s):  
Real World ◽  
Real World Data ◽  
World Data
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