scholarly journals Long-term incidence of glioma in Olmsted County, Minnesota, and disparities in postglioma survival rate: a population-based study

2019 ◽  
Vol 7 (3) ◽  
pp. 288-298
Author(s):  
Conor S Ryan ◽  
Young J Juhn ◽  
Harsheen Kaur ◽  
Chung-Il Wi ◽  
Euijung Ryu ◽  
...  
Keyword(s):  
Survival Rate ◽  
Survival Rates ◽  
Population Based ◽  
Incidence Rates ◽  
North American Population ◽  
Olmsted County ◽  
Population Based Study ◽  
Individual Housing ◽  
Incidence Trends

Abstract Background We assessed glioma incidence and disparities in postglioma survival rate in the Olmsted County, Minnesota, population. Methods This population-based study assessed the incidence of pathologically confirmed primary gliomas between January 1, 1995, and December 31, 2014. Age- and sex-adjusted incidence rates per 100 000 person-years were calculated and standardized to the US white 2010 population. We compared incidence trends of glioma during our study period with previously published Olmsted County data from 1950 to 1990. We assessed postglioma survival rates among individuals with different socioeconomic status (SES), which was measured by a validated individual HOUsing-based SES index (HOUSES). Results We identified 135 incident glioma cases (93% white) with 20 pediatric (50% female) and 115 adult cases (44% female). Overall incidence rate during our study period, 5.51 per 100 000 person-years (95% CI: 4.56-6.46), showed no significant changes and was similar to that seen in 1950 to 1990, 5.5 per 100 000 person-years. The incidence of pediatric (age < 20 years) glioma was 2.49 (95% CI: 1.40-3.58), whereas adult glioma incidence was 6.47 (95% CI: 5.26-7.67). Among those with grade II to IV gliomas, individuals with lower SES (< median HOUSES) had significantly lower 5-year survival rates compared to those with higher SES, adjusted hazard ratio 1.61 (95% CI: 1.01-2.85). Conclusion In a well-defined North American population, long-term glioma incidence appears stable since 1950. Significant socioeconomic disparities exist for postglioma survival.

scholarly journals Population-based Study of Medulloblastoma: Outcomes in Alberta from 1975 to 1996

2008 ◽  
Vol 35 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Gloria Roldán ◽  
Penny Brasher ◽  
Giacomo Vecil ◽  
Donna Senger ◽  
Barry Rewcastle ◽  
...  
Keyword(s):  
Survival Rate ◽  
Survival Curve ◽  
Extent Of Resection ◽  
Population Based ◽  
Rank Test ◽  
Population Based Study ◽  
Unselected Population ◽  
Long Term Survivors ◽  
Alberta Cancer Registry

Background:The purpose of this study was to determine incidence, survival rate, and prognostic factors as well as the frequency of Collins’ Law Violators (CLVs) in an unselected population of medulloblastoma patients. Collins’ Law dictates that ’cure’ of a child with a tumor occurs after a period that includes the child’s age at diagnosis plus 9 months.Methods:Using the Alberta Cancer Registry a population-based review identified 49 patients with medulloblastoma (19 adults, 30 children) diagnosed from 1975-96. Pathology was reviewed in all cases. All patients had surgical resection, followed by radiotherapy in 47 patients and chemotherapy in 17.Results:The overall 5-year survival was 50%. There was a trend for the extent of resection to be associated with a longer survival (Long rank test, p< 0.06) but this was not significant. Tumor recurrence occurred a median of 22.4 months (range, 6.4-192.3) after diagnosis and median survival after recurrence was 9.3 months (range, 0.4-64.9). The survival curve did not appear to plateau but was affected by tumor-related deaths in 3 (21.4%) of the 21 long-term survivors diagnosed in childhood. These three patients had recurrences a mean of 11.7 years after diagnosis and are designated as CLVs.Conclusions:The survival rate in an unselected population of patients with medulloblastoma is poor. Aggressive resection of the tumors prolongs survival. The Collins’ Law Violators were relatively common and we suggest this concept be abandoned in medulloblastoma.

Analyzing Survival Trends in Multiple Myeloma Patients in Pre and Post-Bortezomib Era Using the SEER Database

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 2639-2639
Author(s):  
Jayadev Manikkam Umakanthan ◽  
Dipesh Uprety ◽  
Vineela Kasireddy
Keyword(s):  
Multiple Myeloma ◽  
Survival Rate ◽  
Survival Rates ◽  
Relative Survival ◽  
Population Based ◽  
P Value ◽  
Relative Standard Error ◽  
Population Based Study ◽  
Male And Female ◽  
Relative Standard

Abstract Background: Bortezomib is an antineoplastic agent that acts through protease inhibition. Since, its approval in 2003 by U.S. Food and Drug administration, it has been used religiously for multiple myeloma. There is no current population based study that assesses the survival benefit in multiple myeloma from bortezomib. We conducted a population based study to evaluate the relative survival rates in multiple myeloma patients in pre and post-Bortezomib era in the United States. Methods: We analyzed the Surveillance, Epidemiology, and End Results (SEER) 18 registry database to compare five-year relative survival rates (RS) among multiple myeloma patients. The study arms were categorized by gender (male and female), race (Caucasians and African-Americans) and age (20-59, ≥60 years). The RS were compared between pre-bortezomib era (1991-2002) and post-bortezomib era (2004-2011). The survival rate accompanied standard errors and the statistical significance was defined as p value <0.05. Results: The database comprised of 57,328 patients. The RS have improved significantly during post-bortezomib era in all cohorts under consideration. There was no significant difference in survival rate between male and female and between the African American and Caucasian. However, the relative survival was much better with the young adult (20-59 years) as compared to adult ≥60 years. The table detailing the relative survival is given below. Conclusion: The Primary treatment protocols for Multiple Myeloma have changed dramatically since the approval of Bortezomib in 2003. Other novel agents introduced in the last decade include thalidomide, Lenalidomide and liposomal doxorubicin that are used in conjunction with Bortezomib. Survival trends continue to improve and we believe this modest improvement in survival rate is mainly due to the introduction of Bortezomib and other novel agents. The next challenge is to find new drugs which would prevent relapses and further prolong survival. Abstract 2639. Table.Study armSubclass of cohortsPre-bortezomib era (1991-2002)Post- bortezomib era (2004-2011)Z scoreP ValueNRS (%)Relative Standard Error (SE) (%)NRS (%)Relative Standard Error (SE) (%) GenderMale13,06634.60.517,76546.10.615.904<0.0001Female11,58032.10.514,91743.70.614.765<0.0001 RaceCaucasian18,83632.90.423,98145.00.519.259<0.0001African American4,27434.70.86,39145.10.98.488<0.0001 Age group20-596,35848.10.69,43960.20.712.920<0.0001>=6018,28827.80.423,24338.40.516.606<0.0001 Total: male and female: 1991-2002; 24,646, RS 33.4%; SE 0.3%; 2004-2011; 32,682, RS 45.0%, SE 0.4%; Z score 21.766, P value <0.0001. Disclosures No relevant conflicts of interest to declare.

Long-term fracture risk in patients with Crohn's disease: A population-based study in Olmsted County, Minnesota

2002 ◽  
Vol 123 (2) ◽  
pp. 468-475 ◽  
Author(s):  
Edward V. Loftus ◽  
Cynthia S. Crowson ◽  
William J. Sandborn ◽  
William J. Tremaine ◽  
William M. O'Fallon ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Fracture Risk ◽  
Population Based ◽  
Olmsted County ◽  
Population Based Study

Long-term Trends in Thyroid Carcinoma: A Population-Based Study in Olmsted County, Minnesota, 1935-1999

2005 ◽  
Vol 80 (6) ◽  
pp. 753-758 ◽  
Author(s):  
James P. Burke ◽  
Ian D. Hay ◽  
Fiona Dignan ◽  
John R. Goellner ◽  
Sara J. Achenbach ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Population Based ◽  
Olmsted County ◽  
Population Based Study ◽  
Long Term Trends

scholarly journals Overview of Cardiomyopathies in Childhood

2021 ◽  
Vol 9 ◽  
Author(s):  
Anika Rath ◽  
Robert Weintraub
Keyword(s):  
Natural History ◽  
Heart Transplantation ◽  
Survival Rates ◽  
Population Based ◽  
Left Ventricular ◽  
Term Survival ◽  
Population Based Study ◽  
Presenting Symptoms ◽  
Heterogenous Group

Paediatric cardiomyopathies are a heterogenous group of rare disorders, characterised by mechanical and electrical abnormalities of the heart muscle. The overall annual incidence of childhood cardiomyopathies is estimated at about 1 per 100,000 children and is significantly higher during the first 2 years of life. Dilated cardiomyopathies account for approximately half of the cases. Hypertrophic cardiomyopathies form the second largest group, followed by the less common left ventricular non-compaction and restrictive phenotypes. Infectious, metabolic, genetic, and syndromic conditions account for the majority of cases. Congestive heart failure is the typical manifestation in children with dilated cardiomyopathy, whereas presenting symptoms are more variable in other phenotypes. The natural history is largely influenced by the type of cardiomyopathy and its underlying aetiology. Results from a national population-based study revealed 10-year transplant-free survival rates of 80, 62, and 48% for hypertrophic, dilated and left ventricular non-compaction cardiomyopathies, respectively. Long-term survival rates of children with a restrictive phenotype have largely been obscured by early listing for heart transplantation. In general, the majority of adverse events, including death and heart transplantation, occur during the first 2 years after the initial presentation. This review provides an overview of childhood cardiomyopathies with a focus on epidemiology, natural history, and outcomes.

Clinical Manifestations and Survival Rates among Patients with Saccular Intracranial Aneurysms: Population-based Study in Olmsted County, Minnesota, 1965 to 1995

Neurosurgery ◽  
2001 ◽  
Vol 49 (2) ◽  
pp. 251-258 ◽  
Author(s):  
Vanessa V. Menghini ◽  
Robert D. Brown ◽  
JoRean D. Sicks ◽  
W. Michael O’Fallon ◽  
David O. Wiebers
Keyword(s):  
Intracranial Aneurysms ◽  
Survival Rates ◽  
Clinical Manifestations ◽  
Population Based ◽  
Olmsted County ◽  
Population Based Study

Long-term Trends in Thyroid Carcinoma: A Population-Based Study in Olmsted County, Minnesota, 1935-1999

2005 ◽  
Vol 80 (6) ◽  
pp. 753-758 ◽  
Author(s):  
James P. Burke ◽  
Ian D. Hay ◽  
Fiona Dignan ◽  
John R. Goellner ◽  
Sara J. Achenbach ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Population Based ◽  
Olmsted County ◽  
Population Based Study ◽  
Long Term Trends

scholarly journals Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

2007 ◽  
Vol 53 (4) ◽  
pp. 964-971 ◽  
Author(s):  
Mohammed R. Jafri ◽  
Charles W. Nordstrom ◽  
Joseph A. Murray ◽  
Carol T. Van Dyke ◽  
Ross A. Dierkhising ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Fracture Risk ◽  
Population Based ◽  
Olmsted County ◽  
Population Based Study
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