Qualitative aspects of diet affecting visceral and subcutaneous abdominal adipose tissue: a systematic review of observational and controlled intervention studies

The purpose of our study was to evaluate the potential inhibition of adipose tissue mobilization by lactate. Eight male subjects (age, 26.25 ± 1.75 yr) in good physical condition (maximal oxygen uptake, 59.87 ± 2.77 ml ⋅ kg−1 ⋅ min−1; %body fat, 10.15 ± 0.89%) participated in this study. For each subject, two microdialysis probes were inserted into abdominal subcutaneous tissue. Lactate (16 mM) was perfused via one of the probes while physiological saline only was perfused via the other, both at a flow rate of 2.5 μl/min. In both probes, ethanol was also perfused for adipose tissue blood flow estimation. Dialysates were collected every 10 min during rest (30 min), exercise at 50% maximal oxygen consumption (120 min), and recovery (30 min) for the measurement of glycerol concentration. During exercise, glycerol increased significantly in both probes. However, no differences in glycerol level and ethanol extraction were observed between the lactate and control probes. These findings suggest that lactate does not impair subcutaneous abdominal adipose tissue mobilization during exercise.

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Intra‐Abdominal Adipose Tissue Quantification by Alternative Versus Reference Methods: A Systematic Review and Meta‐Analysis

Obesity ◽

10.1002/oby.22494 ◽

2019 ◽

Cited By ~ 3

Author(s):

Jessica Murphy ◽

Simon L. Bacon ◽

José A. Morais ◽

Michael A. Tsoukas ◽

Sylvia Santosa

Keyword(s):

Systematic Review ◽

Adipose Tissue ◽

Meta Analysis ◽

Abdominal Adipose Tissue ◽

Reference Methods ◽

Tissue Quantification

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An in vivo study of the cortisol-cortisone shuttle in subcutaneous abdominal adipose tissue

Clinical Endocrinology ◽

10.1046/j.1365-2265.1999.00598.x ◽

1999 ◽

Vol 50 (1) ◽

pp. 63-68 ◽

Cited By ~ 49

Author(s):

J. R. Katz ◽

V. Mohamed-Ali ◽

P. J. Wood ◽

J. S. Yudkin ◽

S. W. Coppack

Keyword(s):

Adipose Tissue ◽

In Vivo Study ◽

Abdominal Adipose Tissue ◽

Subcutaneous Abdominal Adipose Tissue

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Effects of Hypo- and Hyperthyroidism on Noradrenergic Activity and Glycerol Concentrations in Human Subcutaneous Abdominal Adipose Tissue Assessed with Microdialysis

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2003-030576 ◽

2003 ◽

Vol 88 (12) ◽

pp. 5605-5608 ◽

Cited By ~ 32

Author(s):

Martin Haluzik ◽

Jara Nedvidkova ◽

Vladimir Bartak ◽

Ivana Dostalova ◽

Petr Vlcek ◽

...

Keyword(s):

Adipose Tissue ◽

Thyroid Hormones ◽

Relative Magnitude ◽

In Vivo Microdialysis ◽

Abdominal Adipose Tissue ◽

Subcutaneous Abdominal Adipose Tissue ◽

Hypothyroid Patients ◽

Hyperthyroid Patients ◽

Tissue Norepinephrine

Abstract Thyroid hormones play a major role in lipid metabolism. However, whether they directly affect lipolysis locally in the adipose tissue remains unknown. Therefore, we measured abdominal sc adipose tissue norepinephrine (NE), basal, and isoprenaline-stimulated lipolysis in 12 hypothyroid patients (HYPO), six hyperthyroid patients (HYPER), and 12 healthy controls by in vivo microdialysis. Adipose tissue NE was decreased in HYPO and increased in HYPER compared with controls (90.4 ± 2.9 and 458.0 ± 69.1 vs. 294.9 ± 19.5 pmol/liter, P < 0.01). Similarly, basal lipolysis, assessed by glycerol assay, was lower in HYPO and higher in HYPER than in controls (88.2 ± 9.9 and 566.0 ± 42.0 vs. 214.3 ± 5.1 μmol/liter P < 0.01). The relative magnitude of isoprenaline-induced glycerol increase was smaller in HYPO (39 ± 19.4%, P < 0.05 vs. basal) and higher in HYPER (277 ± 30.4%, P < 0.01) than in controls (117 ± 5.6%, P < 0.01). The corresponding changes in NE after isoprenaline stimulation were as follows: 120 ± 9.2% (P < 0.05), 503 ± 113% (P < 0.01), and 267 ± 17.2 (P < 0.01). In summary, by affecting local NE levels and adrenergic postreceptor signaling, thyroid hormones may influence the lipolysis rate in the abdominal sc adipose tissue.

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