scholarly journals “Acute Q fever with dermatologic manifestations, molecular diagnosis, and no seroconversion”

2021 ◽  
Author(s):  
Natalí Uribe Pulido ◽  
Clara Escorcia García ◽  
Ruth Cabrera Orrego ◽  
Lina Andrea Gutiérrez ◽  
Carlos Andrés Agudelo
Keyword(s):  
Incubation Period ◽  
Coxiella Burnetii ◽  
Real Time Pcr ◽  
Peripheral Blood ◽  
Genomic Dna ◽  
Molecular Detection ◽  
Q Fever ◽  
Acute Infection ◽  
Acute Q Fever ◽  
Dermatologic Manifestations

Abstract We herein described a case of acute infection by Coxiella burnetii (acute Q fever) that started with a short incubation period and showed prominent dermatological manifestations and unusual serological behavior. The infection was confirmed by molecular detection through real-time PCR using genomic DNA collected from peripheral blood.

scholarly journals Molecular detection of Coxiella burnetii infection in aborted samples of domestic ruminants in Iran

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250116
Author(s):  
Ashraf Mohabati Mobarez ◽  
Mohammad Khalili ◽  
Ehsan Mostafavi ◽  
Saber Esmaeili
Keyword(s):  
Coxiella Burnetii ◽  
Real Time Pcr ◽  
Molecular Detection ◽  
Q Fever ◽  
Domestic Animal ◽  
Domestic Ruminant ◽  
Domestic Ruminants ◽  
Pcr Targeting ◽  
Different Parts

Background Coxiella burnetii is the causative agent of Q fever which is a highly infectious zoonotic disease. C. burnetii has become one of the most important causes of abortion in livestock, which can lead to widespread abortions in these animals. There are very limited studies on the prevalence of C. burnetii infection in cases of animal abortion in Iran. The aim of this study was to investigate the occurrence of C. burnetii in ruminant abortion samples in Iran. Methods Abortion samples from cattle, sheep and goats were collected from different parts of Iran and were tested using Real-time PCR targeting the IS1111 element of C. burnetii. Results In this study, 36 samples (24.7%) of the 146 collected samples were positive for C. burnetii. The prevalence of C. burnetii was 21.3% (20 of 94 samples) in sheep samples. Also, 10 of 46 cattle samples (21.7%) were positive. All six goat abortion samples were positive for C. burnetii. Conclusions The findings of the study demonstrate that C. burnetii plays an important role in domestic ruminant abortions in Iran, suggesting that more attention should be paid to the role of C. burnetii in domestic animal abortions by veterinary organizations. The risk of transmitting the infection to humans due to abortion of animals should also be considered.

scholarly journals Diagnostic usefulness of molecular detection of Coxiella burnetii from blood of patients with suspected acute Q fever

Medicine ◽  
2019 ◽  
Vol 98 (23) ◽  
pp. e15724 ◽  
Author(s):  
Moonsuk Bae ◽  
Choong Eun Jin ◽  
Joung Ha Park ◽  
Min Jae Kim ◽  
Yong Pil Chong ◽  
...  
Keyword(s):  
Coxiella Burnetii ◽  
Molecular Detection ◽  
Q Fever ◽  
Diagnostic Usefulness ◽  
Acute Q Fever

Q fever: a rare but potentially life-threatening zoonotic disease

2021 ◽  
Vol 14 (2) ◽  
pp. e237155
Author(s):  
Pranav Mahajan ◽  
Kailash Pant ◽  
Shirin Majdizadeh
Keyword(s):  
Chronic Disease ◽  
Cardiovascular System ◽  
Q Fever ◽  
Acute Infection ◽  
Acute Illness ◽  
Unknown Aetiology ◽  
Severe Hepatitis ◽  
The Usa ◽  
Life Threatening ◽  
Acute Q Fever

Q fever can present as a fever of unknown aetiology and can be challenging to diagnose because of the rare incidence. It can present as an acute illness with manifestations, including influenza-like symptoms, hepatitis, pneumonia or chronic disease involving the cardiovascular system. We present a case of a 39-year-old woman in the USA, who developed acute Q fever with associated sepsis and severe hepatitis. She received treatment with recovery from acute infection but currently has symptoms of post Q fever syndrome.

scholarly journals Pregnancy outcomes of Q fever : Prospective follow-up study on Reunion Island

2019 ◽  
Author(s):  
Yoan Mboussou ◽  
Julien Jaubert ◽  
Sophie Larrieu ◽  
Laura Atiana ◽  
Florence Naze ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Q Fever ◽  
Acute Infection ◽  
Reunion Island ◽  
Phase 2 ◽  
Follow Up Study ◽  
Réunion Island ◽  
Acute Q Fever

Abstract Background Q fever has been associated with perinatal complications. We conducted a prospective follow-up study to assess both the incidence of adverse pregnancy outcomes (APOs) associated with Coxiella burnetii infection and the contribution of Q fever to APOs. Methods Between May 1 and October 31, 2013, within the regional perinatal health care centre of Saint Pierre, Reunion island, we investigated unexplained miscarriages, stillbirths, preterm births or small-for-gestational age children. Seropositivity for C. burnetii antibodies was defined using indirect immunofluorescence for a phase 2 IgG titre ≥1:64. Acute Q fever was defined for a high phase 2 IgG titre ≥1:256 (compatible with recent or active infection) or the detection of C. burnetii genome in miscarriage products and placentas. Incidence rate ratios (IRR) for Q fever related APOs (taken as a composite outcome or individually) were assessed using Poisson regression models for dichotomous outcomes controlling major confounders. Results Over a 6-month period, 179 pregnant women suspected or diagnosed with an APO were investigated for Q fever, of whom 118 met the definition for an APO. Of these, 19 were seropositive and 10 presented a profile indicative of an acute infection. For three women with an acute Q fever, the chronology between the onset of infection, the APO (2 miscarriages, 1 preterm birth) and the seroconversion suggested causality in the pathogenesis. The cumulative incidence of Q fever related APOs was estimated between 2.2‰ and 5.2‰, whether causality was required or not. Both C. burnetii exposure and acute Q fever were independently associated with APOs (IRR 1.55, 95% CI 1.31-1.84; IRR 1.47, 95% CI 1.15-1.89, respectively). Conclusions In the endemic context of Reunion island, acute Q fever may lead to APOs. To limit the burden of Q fever on reproduction, pregnant women should be kept away from farms and avoid direct contact with ruminants.

scholarly journals Bacteriostatic and Bactericidal Activities of Tigecycline against Coxiella burnetii and Comparison with Those of Six Other Antibiotics

2009 ◽  
Vol 53 (6) ◽  
pp. 2690-2692 ◽  
Author(s):  
Ioanna Spyridaki ◽  
Anna Psaroulaki ◽  
Iosif Vranakis ◽  
Yannis Tselentis ◽  
Achilleas Gikas
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Vero Cells ◽  
In Vitro Susceptibility ◽  
Shell Vial ◽  
Bactericidal Activities ◽  
Acute Q Fever ◽  
Reference Strains ◽  
Shell Vial Assay

ABSTRACT The present article is a study of the in vitro susceptibility of eight Greek Coxiella burnetii isolates, derived from patients with acute Q fever, and two reference strains of Coxiella burnetii to tigecycline. The bacteriostatic activity of tigecycline was compared with those of six other antibiotics using a shell vial assay. The MICs of the examined antibiotics were as follows: tigecycline ranged from 0.25 to 0.5 μg/ml; doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 μg/ml; linezolid and clarithromycin ranged from 2 to 4 μg/ml; and ciprofloxacin ranged from 4 to 8 μg/ml. Tigecycline was effective in inhibiting the infection of Vero cells by C. burnetii. No bactericidal activity was observed against C. burnetii at 4 μg/ml.

scholarly journals Molecular detection of Coxiella burnetii from the formalin-fixed tissues of Q fever patients with acute hepatitis

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180237 ◽  
Author(s):  
Young-Rock Jang ◽  
Yong Shin ◽  
Choong Eun Jin ◽  
Bonhan Koo ◽  
Se Yoon Park ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Coxiella Burnetii ◽  
Molecular Detection ◽  
Q Fever ◽  
Formalin Fixed

scholarly journals Isolation of Coxiella burnetii from serum of patients with acute Q fever

2015 ◽  
Vol 119 ◽  
pp. 74-78 ◽  
Author(s):  
Gemma A. Vincent ◽  
Stephen R. Graves ◽  
Jennifer M. Robson ◽  
Chelsea Nguyen ◽  
Hazizul Hussain-Yusuf ◽  
...  
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Acute Q Fever

scholarly journals Molecular detection of Coxiella burnetii in blood and sera during Q fever

QJM ◽  
2005 ◽  
Vol 98 (8) ◽  
pp. 615-620 ◽  
Author(s):  
J.-M. Rolain ◽  
D. Raoult
Keyword(s):  
Coxiella Burnetii ◽  
Molecular Detection ◽  
Q Fever
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