Calcium Requirement and Inhibitor Spectrum for Intracellular HIV Type 1 gp160 Processing in Cultured HeLa Cells and CD4+ Lymphocytes: Similarity to Those of Viral Envelope Glycoprotein Maturase1

1995 ◽  
Vol 117 (6) ◽  
pp. 1244-1253 ◽  
Author(s):  
Keiichi Kamoshita ◽  
Mayumi Shiota ◽  
Masafumi Sasaki ◽  
Yasuhiro Koga ◽  
Yuushi Okumura ◽  
...  
Keyword(s):  
Hela Cells ◽  
Envelope Glycoprotein ◽  
Viral Envelope ◽  
Viral Envelope Glycoprotein ◽  
Calcium Requirement ◽  
Hiv Type 1 ◽  
Cd4 Lymphocytes

What studies of fusion peptides tell us about viral envelope glycoprotein-mediated membrane fusion (Review)

1997 ◽  
Vol 14 (3) ◽  
pp. 97-112 ◽  
Author(s):  
Stewart R. Durell ◽  
Isabelle Martin ◽  
Jean-Marie Ruysschaert ◽  
Yechiel Shai ◽  
Robert Blumenthal
Keyword(s):  
Membrane Fusion ◽  
Envelope Glycoprotein ◽  
Viral Envelope ◽  
Fusion Peptides ◽  
Viral Envelope Glycoprotein

scholarly journals An Unrelated Monoclonal Antibody Neutralizes Human Immunodeficiency Virus Type 1 by Binding to an Artificial Epitope Engineered in a Functionally Neutral Region of the Viral Envelope Glycoproteins

2005 ◽  
Vol 79 (9) ◽  
pp. 5616-5624 ◽  
Author(s):  
Xinping Ren ◽  
Joseph Sodroski ◽  
Xinzhen Yang
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Envelope Glycoprotein ◽  
Virus Entry ◽  
Neutralizing Antibody ◽  
Viral Envelope ◽  
Epitope Tag ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Neutralizing antibodies often recognize regions of viral envelope glycoproteins that play a role in receptor binding or other aspects of virus entry. To address whether this is a necessary feature of a neutralizing antibody, we identified the V4 region of the gp120 envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) as a sequence that is tolerant of drastic change and thus appears to play a negligible role in envelope glycoprotein function. An artificial epitope tag was inserted into the V4 region without a significant effect on virus entry or neutralization by antibodies that recognize HIV-1 envelope glycoprotein sequences. An antibody directed against the artificial epitope tag was able to neutralize the modified, but not the wild-type, HIV-1. Thus, the specific target of a neutralizing antibody need not contribute functionally to the process of virus entry.

Analysis of the Interaction of Antibodies with a Conserved, Enzymatically Deglycosylated Core of the HIV Type 1 Envelope Glycoprotein 120

1998 ◽  
Vol 14 (3) ◽  
pp. 191-198 ◽  
Author(s):  
JAMES M. BINLEY ◽  
RICHARD WYATT ◽  
ELIZABETH DESJARDINS ◽  
PETER D. KWONG ◽  
WAYNE HENDRICKSON ◽  
...  
Keyword(s):  
Envelope Glycoprotein ◽  
Hiv Type 1

Human CD38 interferes with HIV‐1 fusion through a sequence homologous to the V3 loop of the viral envelope glycoprotein gp120.

2003 ◽  
Vol 17 (3) ◽  
pp. 1-20 ◽  
Author(s):  
Andrea Savarino ◽  
Thea Bensi ◽  
Annalisa Chiocchetti ◽  
Flavia Bottarel ◽  
Riccardo Mesturini ◽  
...  
Keyword(s):  
Envelope Glycoprotein ◽  
Viral Envelope ◽  
V3 Loop ◽  
Viral Envelope Glycoprotein ◽  
Envelope Glycoprotein Gp120 ◽  
Glycoprotein Gp120 ◽  
Hiv 1
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