Pollen Sensitization in Association with Allergic Rhinitis in preschool asthmatic Children

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Elham M Hossny ◽  
Hanan M Abd El-Lateef ◽  
Hadeer FM Salama
Keyword(s):  
Allergic Rhinitis ◽  
Grass Pollen ◽  
Skin Prick Testing ◽  
Cross Sectional Study ◽  
Negative Control ◽  
Phleum Pratense ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Timothy Grass ◽  
Timothy Grass Pollen

Abstract Background Grass pollens are significant elicitors of IgE-mediated allergic disease in the world and timothy grass (Phleum pratense) is an important pollen in allergy induction. Objective We sought to determine the rate of pollen sensitization in group of Egyptian asthmatic children with allergic rhinitis using timothy grass pollen as a potential triggering factor for allergic rhinitis. Patients and Methods This analytical cross sectional study was conducted on a group of preschool children following up at the Pediatric Allergy and Immunology Clinic, Children's Hospital, Ain Shams University during the period from December 2018 to April 2019. We enrolled 52 asthmatic children with concomitant allergic rhinitis sampled in a consecutive manner. They were subjected to skin prick testing for timothy grass pollen, positive histamine control and negative control. Results The study revealed high frequency of timothy grass pollen(TGP) sensitization occurring in 60.3% of patients with concomitant allergic rhinitis .wheal diameters pointed to sensitization only rather than actual allergy to TGP. TGP sensitization showed no significant correlation to disease duration. Children with rhinosinsuitis had comparable rates of TGP sensitization to those without rhinosinsuitis. Conclusion It is concluded from our results that sensitization to timothy grass pollen (TGP) is common in allergic rhinitis. The findings are limited by the sample size and consecutive manner of sampling. Wider scale studies are needed to accurately evaluate the frequency of timothy grass pollen (TGP) sensitization in our country.

scholarly journals Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

2015 ◽  
pp. 5897 ◽  
Author(s):  
Alessandra Scaparrotta ◽  
Marina Attanasi ◽  
Marianna Petrosino ◽  
Paola Di Filippo ◽  
Sabrina Di Pillo ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Grass Pollen ◽  
Critical Appraisal ◽  
Pollen Extract ◽  
Timothy Grass ◽  
Timothy Grass Pollen

scholarly journals Sensitization to indoor allergens and frequency of asthma exacerbations in children

2011 ◽  
Vol 51 (4) ◽  
pp. 207 ◽  
Author(s):  
Irene Irene ◽  
Putu Siadi Purniti ◽  
Sumadiono Sumadiono
Keyword(s):  
Respiratory Infections ◽  
Cross Sectional Study ◽  
Negative Control ◽  
Indoor Allergens ◽  
Cross Sectional ◽  
Positive Skin ◽  
Asthmatic Children ◽  
Asthma Incidence ◽  
Asthma Exacerbations ◽  
Wheal Diameter

Background The rapid increase in asthma incidence has implicated the importance of environmental influences over genetic influences. Sensitization to perennial indoor allergens has been associated with increased asthma symptoms.Objective To examine the correlation between sensitization to indoor allergens and frequency of asthma exacerbations in children.Methods A cross-sectional study was carried out on asthmatic children aged 6 to 12 years in the Department of Child Health, Udayana University Medical School /Sanglah Hospital, Denpasar. Degree of sensitization was assessed by mean wheal diameter (positive defined as 3 mm greater than negative control) for seven common indoor allergens. Frequency of asthma exacerbation for three consecutive months prior to data collection was retrospectively reviewed.Results Positive skin test results for one or more allergens were found in 84 of 89 (94%) asthmatic children. Higher frequency of asthma exacerbations weakly correlated with the number of allergens with positive sensitization (r=0.284; P=0.007). Mean wheal diameter of each allergen did not correlate to the frequency of asthma exacerbations. In addition, the frequency of asthma exacerbations was independent for parental and sibling atopic history, preceding respiratory infections, use of asthma controllers and passive environmental tobacco smoke exposure.Conclusions Sensitization to common indoor allergens correlates weakly with frequency of asthma exacerbations. 

Solution structure of Phl p 3, a major allergen from timothy grass pollen

2008 ◽  
Vol 389 (7) ◽  
Author(s):  
Kristian Schweimer ◽  
Arnd Petersen ◽  
Roland Suck ◽  
Wolf-Meinhard Becker ◽  
Paul Rösch ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Solution Structure ◽  
Major Allergen ◽  
Phleum Pratense ◽  
Resonance Spectroscopy ◽  
Timothy Grass ◽  
Carboxy Terminal Domain ◽  
Timothy Grass Pollen ◽  
Group 3 ◽  
Carboxy Terminal

Abstract The major 97-aa timothy grass (Phleum pratense) allergen Phl p 3 was recently isolated from an extract of timothy grass pollen. Sequence comparison classifies this protein as a group 3 allergen. The solution structure of Phl p 3 as determined by nuclear magnetic resonance spectroscopy reveals that the protein consists of a core of hydrophobic amino-acid side chains from two β-sheets of five and four anti-parallel β-strands, respectively. This conformation is very similar to the crystal structure published for Phl p 2 and strongly resembles the known conformation of the carboxy-terminal domain of Phl p 1, the major difference being the loop orientations. Phl p 2 and Phl p 3 show virtually identical immunoreactivity, and comparison of the charged surface amino acids of the two proteins gives initial clues as to the IgE recognition epitopes of these proteins.

scholarly journals Sensitization to timothy grass pollen allergenic molecules in children

2013 ◽  
Vol 8 ◽  
Author(s):  
Alessandra Scaparrotta ◽  
Marcello Verini ◽  
Nicola Pietro Consilvio ◽  
Anna Cingolani ◽  
Daniele Rapino ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Pollen Allergy ◽  
Phleum Pratense ◽  
Pollen Extract ◽  
Mediterranean Population ◽  
Grass Pollen Allergy ◽  
Timothy Grass ◽  
Timothy Grass Pollen ◽  
Species Specific

Background: Grass pollens are significant elicitors of IgE-mediated allergic disease in the world and timothy (Phleum pratense) is one of the most important pollens of the family. Molecular and biochemical characterization of Phleum pratense has revealed several allergen components: rPhl p 1 and rPhl p 5 have been shown to be “Species Specific Allergens”, while the profilin rPhl p 12 and the calcium-binding protein rPhl p 7 are the principal Cross-Reactive components. Methods: In this study the pattern of sensitization to rPhl p 1, rPhl p 5, rPhl p 7 and rPhl p 12 was analyzed in children with asthma and/or rhinoconjunctivitis and grass pollen allergy, in order to evaluate the frequency of sensitization to allergenic molecules of Phleum pratense among pediatric subjects allergic to grass pollen in a Mediterranean population. The correlation of sensitization to these Phleum allergenic molecules with IgE against grass pollen extract and its variation according to age and level of IgE against grass pollen extract were evaluated. Results: IgE against to rPhl p 1 were found in 99% (205/207) of patients, to rPhl p 5 in 67% (139/207), to rPhl p 12 in 32% (66/207) and to rPhl p 7 only in 5% (10/207). Sensitization only to “Species Specific” (rPhl p1, rPhl p5) allergenic molecules of Phleum pratense was detected in 65% (135/207) of children. Our data show the predominant role of rPhl p 1 in pediatric populations as the most relevant sensitizing allergen detectable at all ages and at all levels of timothy grass pollen-specific IgE antibodies, while the importance of rPhl p 5 rises with the increase of patients’ age and with grass pollen IgE levels. Conclusions: The assessment of sensitization to grass pollen allergenic molecules could help develop a better characterization of allergic sensitization in grass pollen allergy in children, which may be different in every patient. It could also enable clinicians to give more specific and effective immunotherapy, based on allergenic molecule sensitization.

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