scholarly journals Injectable Self-Healing Ceria-based Nanocomposite Hydrogel with ROS-scavenging Activity for Skin Wound Repair

2021 ◽  
Author(s):  
Xueyun Gong ◽  
Meng Luo ◽  
Min Wang ◽  
Wen Niu ◽  
Yidan Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Skin Wound ◽  
Scavenging Activity ◽  
Self Healing ◽  
Nanocomposite Hydrogel ◽  
Full Thickness ◽  
Ros Scavenging ◽  
Full Thickness Skin ◽  
Thickness Skin

Abstract Excessive reactive oxygen species (ROS) in the injured skin may impede the wound repair and skin regeneration. Herein, we develop an injectable self-healing ceria-based nanocomposite hydrogel with ROS-scavenging activity to accelerate wound healing. The nanocomposite hydrogels were successfully prepared by coating cerium oxide nanorods with polyethylenimine (PEI) and crosslinked with benzaldehyde-terminated F127 (F127-CHO) through the dynamic Schiff-base reaction (FVEC hydrogel). The results showed that the FVEC hydrogel possessed the good thermosensitivity, injectability, self-healing ability and ROS scavenging activity. The subcutaneous implantation experiments in mice confirmed that FVEC hydrogels are biocompatible and biodegradable in vivo. The full-thickness skin wound studies showed that FVEC hydrogel could significantly enhance the wound healing and epithelium regeneration with the formation of hair follicle and adipocyte tissue. This work provides a new strategy for the development of multifunctional Ce-based nanocomposite hydrogel for full-thickness skin wound healing and regeneration.

Injectable Adhesive Self-Healing Multicross-Linked Double-Network Hydrogel Facilitates Full-Thickness Skin Wound Healing

2020 ◽  
Vol 12 (52) ◽  
pp. 57782-57797
Author(s):  
Bo Yang ◽  
Jiliang Song ◽  
Yuhang Jiang ◽  
Ming Li ◽  
Jingjing Wei ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Self Healing ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Double Network ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Pharmaceutical application of frog skin on full-thickness skin wound healing in mice

2013 ◽  
Vol 51 (12) ◽  
pp. 1600-1606 ◽  
Author(s):  
Mahere Rezazade Bazaz ◽  
Mohammad Mashreghi ◽  
Nasser Mahdavi Shahri ◽  
Mansour Mashreghi ◽  
Ahmad Asoodeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Frog Skin ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Pharmaceutical Application ◽  
Thickness Skin

Comparison of five dermal substitutes in full-thickness skin wound healing in a porcine model

Burns ◽  
2012 ◽  
Vol 38 (6) ◽  
pp. 820-829 ◽  
Author(s):  
Cécile Philandrianos ◽  
Lucile Andrac-Meyer ◽  
Serge Mordon ◽  
Jean-Marc Feuerstein ◽  
Florence Sabatier ◽  
...  
Keyword(s):  
Wound Healing ◽  
Porcine Model ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Dermal Substitutes ◽  
Full Thickness Skin ◽  
Thickness Skin

Evaluation of the Effect of the Structure of Bacterial Cellulose on Full Thickness Skin Wound Repair on a Microfluidic Chip

2015 ◽  
Vol 16 (3) ◽  
pp. 780-789 ◽  
Author(s):  
Ying Li ◽  
Shiwen Wang ◽  
Rong Huang ◽  
Zhuo Huang ◽  
Binfeng Hu ◽  
...  
Keyword(s):  
Bacterial Cellulose ◽  
Microfluidic Chip ◽  
Wound Repair ◽  
Skin Wound ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Large full-thickness wounded skin regeneration using 3D-printed elastic scaffold with minimal functional unit of skin

2022 ◽  
Vol 13 ◽  
pp. 204173142110630
Author(s):  
Peng Chang ◽  
Shijie Li ◽  
Qian Sun ◽  
Kai Guo ◽  
Heran Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Functional Unit ◽  
Collagen Gel ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
3D Printed

Traditional tissue engineering skin are composed of living cells and natural or synthetic scaffold. Besize the time delay and the risk of contamination involved with cell culture, the lack of autologous cell source and the persistence of allogeneic cells in heterologous grafts have limited its application. This study shows a novel tissue engineering functional skin by carrying minimal functional unit of skin (MFUS) in 3D-printed polylactide-co-caprolactone (PLCL) scaffold and collagen gel (PLCL + Col + MFUS). MFUS is full-layer micro skin harvested from rat autologous tail skin. 3D-printed PLCL elastic scaffold has the similar mechanical properties with rat skin which provides a suitable environment for MFUS growing and enhances the skin wound healing. Four large full-thickness skin defects with 30 mm diameter of each wound are created in rat dorsal skin, and treated either with tissue engineering functional skin (PLCL + Col + MFUS), or with 3D-printed PLCL scaffold and collagen gel (PLCL + Col), or with micro skin islands only (Micro skin), or without treatment (Normal healing). The wound treated with PLCL + Col + MFUS heales much faster than the other three groups as evidenced by the fibroblasts migration from fascia to the gap between the MFUS dermis layer, and functional skin with hair follicles and sebaceous gland has been regenerated. The PLCL + Col treated wound heals faster than normal healing wound, but no skin appendages formed in PLCL + Col-treated wound. The wound treated with micro skin islands heals slower than the wounds treated either with tissue engineering skin (PLCL + Col + MFUS) or with PLCL + Col gel. Our results provide a new strategy to use autologous MFUS instead “seed cells” as the bio-resource of engineering skin for large full-thickness skin wound healing.

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