Abatacept concentrations in maternal serum and breast milk during breastfeeding and an infant safety assessment: a case study

Rheumatology ◽  
2019 ◽  
Vol 58 (9) ◽  
pp. 1692-1694 ◽  
Author(s):  
Jumpei Saito ◽  
Naho Yakuwa ◽  
Chinatsu Takai ◽  
Kayoko Kaneko ◽  
Mikako Goto ◽  
...  
Keyword(s):  
Breast Milk ◽  
Safety Assessment ◽  
Maternal Serum ◽  
Infant Safety

scholarly journals Belimumab Concentrations in Maternal Serum and Breast Milk During Breastfeeding and the Safety Assessment of the Infant: A Case Study

2020 ◽  
Vol 15 (7) ◽  
pp. 475-477
Author(s):  
Jumpei Saito ◽  
Naho Yakuwa ◽  
Tatsuo Ishizuka ◽  
Mikako Goto ◽  
Akimasa Yamatani ◽  
...  
Keyword(s):  
Breast Milk ◽  
Safety Assessment ◽  
Maternal Serum

scholarly journals Tocilizumab concentrations in maternal serum and breast milk during breastfeeding and a safety assessment in infants: a case study

Rheumatology ◽  
2018 ◽  
Vol 57 (8) ◽  
pp. 1499-1501 ◽  
Author(s):  
Jumpei Saito ◽  
Naho Yakuwa ◽  
Chinatsu Takai ◽  
Ken Nakajima ◽  
Kayoko Kaneko ◽  
...  
Keyword(s):  
Breast Milk ◽  
Safety Assessment ◽  
Maternal Serum

scholarly journals Impact of Maternal Daily Oral Low-Dose Vitamin A Supplementation on the Mother–Infant Pair: A Randomised Placebo-Controlled Trial in China

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2370
Author(s):  
Ye Ding ◽  
Ping Hu ◽  
Yue Yang ◽  
Fangping Xu ◽  
Fang Li ◽  
...  
Keyword(s):  
Health Status ◽  
Breast Milk ◽  
Vitamin A ◽  
Low Dose ◽  
Maternal Serum ◽  
Control Group ◽  
Vitamin A Supplementation ◽  
Maternal Vitamin ◽  
Vitamin A Status ◽  
Lactating Mothers

Background: The nutritional status of vitamin A in lactating mothers and infants is still not optimistic. Due to the dietary habits and dietary restrictions of postpartum customs in China, vitamin A supplementation has been advocated as a potential strategy to improve vitamin A status of lactating mothers with inadequate dietary vitamin A intake. Existing clinical trials are limited to single or double high-dose maternal administrations. However, in China, vitamin A supplements are readily available in the form of daily oral low-dose supplements, and the effect of these is unknown. This study aimed to evaluate the effects of daily oral low-dose vitamin A supplementation on the retinol levels in the serum and breast milk of lactating mothers and the health status of infants in China. Methods: Lactating mothers who met the inclusion criteria and planned to continue exclusive breastfeeding were randomly assigned to receive either daily oral vitamin A and D drops (one soft capsule of 1800 IU vitamin A and 600 IU vitamin D2), or a matching placebo for 2 months. Before and after the intervention, dietary intake was investigated by instant photography, and the retinol concentration in maternal serum and breast milk was determined by ultra-high performance liquid chromatography-tandem mass spectrometry. During the trial, the health status of infants was diagnosed by a paediatrician or reported by lactating mothers. A total of 245 participants completed the study, with 117 in the supplementation group and 128 in the control group. Results: After the 2-month intervention, maternal serum retinol concentrations increased in the supplementation group with no change in the control group. Although breast milk retinol concentrations decreased significantly in both groups, the decrease in the supplementation group was significantly lower than that in the control group. However, maternal vitamin A supplementation was not associated with a lower risk of infant febrile illness, respiratory tract infection, diarrhoea, and eczema. Conclusions: Daily oral low-dose vitamin A supplementation is helpful in improving maternal vitamin A status, despite having no effect on infant health status through breast milk.

Eplerenone levels in maternal serum, cord blood, and breast milk during pregnancy and lactation

2021 ◽  
Author(s):  
Jumpei Saito ◽  
Asako Mito ◽  
Naho Yakuwa ◽  
Kayoko Kaneko ◽  
Hiroyo Kawasaki ◽  
...  
Keyword(s):  
Breast Milk ◽  
Cord Blood ◽  
Maternal Serum ◽  
Pregnancy And Lactation

Safety Assessment of Long Term Serviced Pressure Vessels: A Case Study of Typical Refining and Chemical Plants in China

2021 ◽  
Author(s):  
Zhiyuan Han ◽  
Guoshan Xie ◽  
Haiyi Jiang ◽  
Xiaowei Li
Keyword(s):  
Pressure Vessel ◽  
Safety Assessment ◽  
Failure Modes ◽  
Pressure Vessels ◽  
Time Dependent ◽  
Chemical Plants ◽  
Safety Specification ◽  
Detailed Assessment

Abstract The safety and risk of the long term serviced pressure vessels, especially which serviced more than 20 years, has become one of the most concerned issues in refining and chemical industry and government safety supervision in China. According to the Chinese pressure vessel safety specification TSG 21-2016 “Supervision Regulation on Safety Technology for Stationary Pressure Vessel”, if necessary, safety assessment should be performed for the pressure vessel which reaches the design service life or exceeds 20 years without a definite design life. However, the safety and risk conditions of most pressure vessels have little changes after long term serviced because their failure modes are time-independent. Thus the key problem is to identify the devices with the time-dependent failure modes and assess them based on the failure modes. This study provided a case study on 16 typical refining and chemical plants including 1870 pressure vessels serviced more than 20 years. The quantitative risk and damage mechanisms were calculated based on API 581, the time-dependent and time-independent failure modes were identified, and the typical pressure vessels were assessed based on API 579. Taking the high pressure hydrogenation plant as an example, this study gave the detailed assessment results and conclusions. The results and suggestions in this study are essential for the safety supervision and extending life of long term serviced pressure vessels in China.

scholarly journals Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord

2018 ◽  
Vol 46 (4) ◽  
pp. 1555-1569 ◽  
Author(s):  
Thalia Manfrin Martins Deminice ◽  
Ivan Savioli Ferraz ◽  
Jacqueline Pontes Monteiro ◽  
Alceu Afonso Jordão ◽  
Lívia Maria Cordeiro Simões Ambrósio ◽  
...  
Keyword(s):  
Breast Milk ◽  
Vitamin A ◽  
Human Milk ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Serum Retinol ◽  
Cross Sectional ◽  
Blood Samples

Objectives To analyse intake of vitamin A (VA) and retinol concentrations in maternal blood, breast milk (BM), and the umbilical cord (UC) of newborns, and to determine the associations among these variables. Methods We performed a cross-sectional, epidemiological study of 180 mother–newborn dyads. Maternal and UC blood samples and BM were collected. VA intake by the mother over 30 days was assessed using a questionnaire. Results Mean retinol concentrations in maternal serum, the UC, and BM were 0.65 ± 0.27, 0.36 ± 0.18, and 2.95 ± 2.70 µmol/L, respectively. Retinol concentrations <0.70 µmol/L were found in 57.2% of maternal blood samples and in 94.9% of UC samples. A total of 27.9% of BM samples showed retinol concentrations <1.05 µmol/L. Mean VA intake by the mothers was 1041.33 ± 1187.86 µg retinol activity equivalents/day and was inadequate (<550 µg retinol activity equivalents/day) in 44.7%. Conclusions High proportions of insufficient retinol concentrations were observed in the UC, maternal blood, and BM. A high percentage of pregnant women had inadequate VA intake. Mothers with insufficient serum retinol concentrations had newborns with lower retinol concentrations in the UC. Higher retinol concentrations were observed in maternal blood and the UC with a higher VA intake.

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