scholarly journals 0108 Brief Periods of Sleep and Quiet Rest Equivalently Benefit Memory Consolidation

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A43-A43
Author(s):  
K C Baker ◽  
S Y Wang ◽  
J L Culbreth ◽  
S C Morris ◽  
M J Arora ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Memory Task ◽  
English Word ◽  
Procedural Memory ◽  
Distractor Task ◽  
Motor Sequence ◽  
Retention Period ◽  
Eyes Closed ◽  
Percent Improvement ◽  
Active Wakefulness

Abstract Introduction Past research has demonstrated that sleep benefits the consolidation of memories. However, more recent studies have suggested that quiet rest could have similar benefits for memory. Here, we examined the effect of a brief period of sleep, quiet rest, or active wakefulness on declarative and procedural memory. We hypothesized that sleep and quiet rest would equally benefit memory, compared to a period of active wakefulness. Methods After completing a declarative (Icelandic-English word pairs) and procedural memory task (the Motor Sequence Task (MST)), participants began a 30-min retention period with PSG monitoring, in which they either slept (n=24), quietly rested with their eyes closed (n=22), or completed a distractor task (n=28). Following the retention period, participants were tested on the same memory tasks they completed earlier. Results Percent improvement on the MST from the end of training to the end of the test session differed by condition, F(2, 73)=4.21, p=.019. Sleep and quiet rest led to nearly identical improvement (p=.95), with improvement in both of these conditions being significantly greater than in active wake (sleep vs. active wake: p=.01; quiet rest vs. active wake: p=.02). Similarly, retention of the Icelandic-English word pairs differed by condition (F(2, 73)=5.68, p=.005), with sleep and quiet rest demonstrating nearly identical memory change over time (p=.81), and retention in both of these conditions being significantly higher than in active wake (sleep vs. active wake: p=.007; quiet rest vs. active wake: p=.004). Conclusion These data suggest that sleep and quiet rest can exert an equivalent effect on memory consolidation for both declarative and procedural memory, at least across very brief retention durations. Therefore, neurobiology specific to sleep might not be necessary to induce offline improvement in memory across short intervals. Support This research was supported by National Institutes of Health Award R15MH107891.

scholarly journals Individual differences in working memory capacity moderate effects of post-learning activity on memory consolidation over the long term

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Markus Martini ◽  
Robert Marhenke ◽  
Caroline Martini ◽  
Sonja Rossi ◽  
Pierre Sachse
Keyword(s):  
Working Memory ◽  
Memory Consolidation ◽  
Working Memory Capacity ◽  
Word List ◽  
Memory Capacity ◽  
Learning Activity ◽  
Experimental Session ◽  
Distractor Task ◽  
Memory Retention ◽  
Eyes Closed

Abstract Similar to sleeping after learning, a brief period of wakeful resting after encoding new information supports memory retention in contrast to task-related cognition. Recent evidence suggests that working memory capacity (WMC) is related to sleep-dependent declarative memory consolidation. We tested whether WMC moderates the effect of a brief period of wakeful resting compared to performing a distractor task subsequent to encoding a word list. Participants encoded and immediately recalled a word list followed by either an 8 min wakeful resting period (eyes closed, relaxed) or by performing an adapted version of the d2 test of attention for 8 min. At the end of the experimental session (after 12–24 min) and again, after 7 days, participants were required to complete a surprise free recall test of both word lists. Our results show that interindividual differences in WMC are a central moderating factor for the effect of post-learning activity on memory retention. The difference in word retention between a brief period of wakeful resting versus performing a selective attention task subsequent to encoding increased in higher WMC individuals over a retention interval of 12–24 min, as well as over 7 days. This effect was reversed in lower WMC individuals. Our results extend findings showing that WMC seems not only to moderate sleep-related but also wakeful resting-related memory consolidation.

scholarly journals Resting States and Memory Consolidation: A Preregistered Replication and Meta-Analysis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Graelyn B. Humiston ◽  
Matthew A. Tucker ◽  
Theodore Summer ◽  
Erin J. Wamsley
Keyword(s):  
Memory Consolidation ◽  
Verbal Memory ◽  
Declarative Memory ◽  
Meta Analysis ◽  
Significant Benefit ◽  
Distractor Task ◽  
Memory Retention ◽  
Eyes Closed ◽  
Spontaneous Thought ◽  
The Mind

AbstractWhile several recent studies have found that a post-encoding period of quiet, eyes-closed waking rest benefits memory consolidation, others have reported null effects. To more precisely estimate this effect, we conducted a quasi-exact behavioural replication of a recent study from our lab, which found that post-training eyes-closed waking rest improved declarative memory relative to a distractor task. Contrary to our hypothesis, the observed effect was not significant; however, it did fall within the 95% confidence interval of our previous finding. Furthermore, a meta-analytic effect summarizing n = 10 similar studies indicates a moderately sized and significant benefit of waking rest for verbal memory (d = 0.38, p < 0.001). We argue that the apparently conflicting results in this literature are most parsimoniously explained by variability due to sampling and/or measurement error, in a group of studies often underpowered to detect a smaller-than-expected effect of rest. Additionally, exploratory analyses revealed that increased trait daydreaming frequency negatively correlated with memory retention during eyes-closed rest. Together with our replication and meta-analysis, these studies suggest that waking rest confers a small but significant benefit on memory consolidation, and that this benefit requires the mind to be free from attention to either external tasks or spontaneous thought.

scholarly journals 0104 The Effect of Time, Sleep, and Wake on Motor Memory Consolidation: A Partial Replication of Walker, Et Al. (2002)

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A41-A42
Author(s):  
M Tucker ◽  
I Wani
Keyword(s):  
Memory Consolidation ◽  
Memory Task ◽  
Skill Learning ◽  
Motor Memory ◽  
Partial Replication ◽  
Motor Sequence ◽  
Training Performance ◽  
Digit Sequence ◽  
Larger Sample ◽  
Typing Task

Abstract Introduction Findings from Walker, et al (2002) ‘Practice with Sleep Makes Perfect: Sleep-Dependent Motor Skill Learning’ demonstrate that performance on a widely used motor memory task (motor sequence task (MST)) benefits from a 12hr period of sleep (and not wake) even if the sleep period does not occur for approximately 12hrs after task acquisition, suggesting that sleep is crucial for motor memory consolidation. Using a larger sample, we attempted to replicate this finding, which is derived from Groups B & D from Walker et al (2002). Methods Participants (64 medical students: Age 21.2±0.8; N=33 females) were trained on the MST in the morning (10am; N=40) or evening (10pm; N=24) and then returned 12 and 24hrs later to be retested. The MST is a simple typing task that requires participants, at training, to type a 5-digit sequence (e.g., 4-1-3-2-4) as fast and accurately as possible over a series of 12 30-second trials with a 30-second break between each trial. At each retest, participants performed three 30-second trials. Results With 75% of the data collected we have found that when sleep follows training in the evening (first 12hr interval), the number of correctly typed sequences increased by 19.1% (cf. 20.5% in Walker (2002)). After a subsequent day of wake (second 12hr interval) performance increased by an additional 7.3% (cf. 2.0%). However, when a day of wake spanned the first 12hrs following training, performance increased by 14.5% (cf. 3.9%) followed by another 14.5% increase over the subsequent night (cf. 14.4%). Performance differences between sleep and wake participants were nonsignificant over the first 12hrs (p=0.38) and second 12hrs (p=0.49). Conclusion With most of data collection complete, our findings only partially replicate those of Walker et al (2002), and may draw into question the robustness of sleep for the processing motor memory. Support None

scholarly journals 0113 Evaluating Closed-Loop Auditory Stimulation During Sleep as an Intervention to Improve Memory Consolidation Deficits in Schizophrenia

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A45-A45
Author(s):  
B Baxter ◽  
K Kwok ◽  
C Talbot ◽  
L Zhu ◽  
D Mylonas ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Memory Consolidation ◽  
Closed Loop ◽  
Declarative Memory ◽  
Procedural Memory ◽  
Auditory Stimulation ◽  
Small Sample ◽  
Healthy Adults ◽  
Sleep Spindles ◽  
Motor Sequence

Abstract Introduction Converging evidence supports the hypothesis that reduced sleep spindles and spindle-slow oscillation (SO) coordination contribute to cognitive deficits in schizophrenia. Closed-loop auditory stimulation in healthy adults increases sleep spindles and improves declarative memory consolidation. Here we investigated whether closed-loop auditory stimulation also improves sleep-dependent procedural memory consolidation as a first step towards an intervention in schizophrenia. Methods Thirteen healthy adults participated in two nap sessions (stimulation or detection only) with polysomnography in a counterbalanced order. Participants were trained on the finger tapping Motor Sequence Task (MST), which measures sleep-dependent motor procedural memory consolidation, prior to napping and were tested after awakening. We detected the negative peak of SOs during non-REM sleep and, in the stimulation condition, delivered 50ms of pink noise during the SO up-state. Results Auditory stimulation increased SOs and spindles during the SO up-state in a frontocentral cluster of electrodes 800-1200ms after stimulation compared to detection only (p&lt;0.05). Stimulation also showed promise for improving memory consolidation (33% increase in MST overnap improvement from detection-only) but this did not reach significance in this small sample and data collection is ongoing. Conclusion Auditory stimulation evoked coordinated spindle-SO events that mediate memory consolidation, but more subjects are needed to evaluate whether it also improves memory. If it does, we will test the effects of stimulation on sleep-dependent memory deficits in patients with schizophrenia. Closed-loop auditory stimulation shows promise as a safe, scalable intervention for cognitive deficits that can be implemented at home with commercially available devices. Support R01 MH67720 (DSM & RS), NIH-NHLBI 5T32HL007901-17 (BB), K24MH099421 (DSM), and Simons Foundation (DSM).

Effect of high-endurance exercise intervention on sleep-dependent procedural memory consolidation in individuals with schizophrenia: a randomized controlled trial

2021 ◽  
pp. 1-13
Author(s):  
Lincoln Lik Hang Lo ◽  
Edwin Ho Ming Lee ◽  
Christy Lai Ming Hui ◽  
Catherine Shiu Yin Chong ◽  
Wing Chung Chang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Physical Exercise ◽  
Endurance Exercise ◽  
Memory Consolidation ◽  
Controlled Trial ◽  
Procedural Memory ◽  
University Hospital ◽  
Control Group ◽  
Motor Sequence ◽  
Randomized Controlled

Abstract Background Little is known about the effects of physical exercise on sleep-dependent consolidation of procedural memory in individuals with schizophrenia. We conducted a randomized controlled trial (RCT) to assess the effectiveness of physical exercise in improving this cognitive function in schizophrenia. Methods A three-arm parallel open-labeled RCT took place in a university hospital. Participants were randomized and allocated into either the high-intensity-interval-training group (HIIT), aerobic-endurance exercise group (AE), or psychoeducation group for 12 weeks, with three sessions per week. Seventy-nine individuals with schizophrenia spectrum disorder were contacted and screened for their eligibility. A total of 51 were successfully recruited in the study. The primary outcome was sleep-dependent procedural memory consolidation performance as measured by the finger-tapping motor sequence task (MST). Assessments were conducted during baseline and follow-up on week 12. Results The MST performance scored significantly higher in the HIIT (n = 17) compared to the psychoeducation group (n = 18) after the week 12 intervention (p < 0.001). The performance differences between the AE (n = 16) and the psychoeducation (p = 0.057), and between the AE and the HIIT (p = 0.999) were not significant. Yet, both HIIT (p < 0.0001) and AE (p < 0.05) showed significant within-group post-intervention improvement. Conclusions Our results show that HIIT and AE were effective at reverting the defective sleep-dependent procedural memory consolidation in individuals with schizophrenia. Moreover, HIIT had a more distinctive effect compared to the control group. These findings suggest that HIIT may be a more effective treatment to improve sleep-dependent memory functions in individuals with schizophrenia than AE alone.

scholarly journals Investigating the Effects of Seizures on Procedural Memory Performance in Patients with Epilepsy

2021 ◽  
Vol 11 (2) ◽  
pp. 261
Author(s):  
Frank J. van Schalkwijk ◽  
Walter R. Gruber ◽  
Laurie A. Miller ◽  
Eugen Trinka ◽  
Yvonne Höller
Keyword(s):  
Temporal Lobe ◽  
Declarative Memory ◽  
Memory Performance ◽  
Total Sample ◽  
Learning Task ◽  
Procedural Memory ◽  
Memory Retention ◽  
Motor Sequence ◽  
Performance Improvements ◽  
Patients With Epilepsy

Memory complaints are frequently reported by patients with epilepsy and are associated with seizure occurrence. Yet, the direct effects of seizures on memory retention are difficult to assess given their unpredictability. Furthermore, previous investigations have predominantly assessed declarative memory. This study evaluated within-subject effects of seizure occurrence on retention and consolidation of a procedural motor sequence learning task in patients with epilepsy undergoing continuous monitoring for five consecutive days. Of the total sample of patients considered for analyses (N = 53, Mage = 32.92 ± 13.80 y, range = 18–66 y; 43% male), 15 patients experienced seizures and were used for within-patient analyses. Within-patient contrasts showed general improvements over seizure-free (day + night) and seizure-affected retention periods. Yet, exploratory within-subject contrasts for patients diagnosed with temporal lobe epilepsy (n = 10) showed that only seizure-free retention periods resulted in significant improvements, as no performance changes were observed following seizure-affected retention. These results indicate general performance improvements and offline consolidation of procedural memory during the day and night. Furthermore, these results suggest the relevance of healthy temporal lobe functioning for successful consolidation of procedural information, as well as the importance of seizure control for effective retention and consolidation of procedural memory.

Effects of Model Performances on Music Skill Acquisition and Overnight Memory Consolidation

2014 ◽  
Vol 62 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Carla D. Cash ◽  
Sarah E. Allen ◽  
Amy L. Simmons ◽  
Robert A. Duke
Keyword(s):  
Skill Acquisition ◽  
Memory Consolidation ◽  
Procedural Memory ◽  
Auditory Model ◽  
Research Participants ◽  
Nondominant Hand ◽  
The Mean ◽  
Rest Intervals

This study was designed to investigate the extent to which the presentation of an auditory model prior to learning a novel melody affects performance during active practice and the overnight consolidation of procedural memory. During evening training sessions, 32 nonpianist musicians practiced a 13-note keyboard melody with their left (nondominant) hand in twelve 30-s practice intervals separated by 30-s rest intervals. Participants were instructed to play the sequence “as quickly, accurately, and evenly as possible.” Approximately half the participants, prior to the first practice interval, listened to 10 repetitions of the target melody played at 552 tones per minute (half note = 138). All participants were tested on the target melody the following morning, approximately 12 hr after training, in three 30-s blocks separated by 30-s rest intervals. Performance was measured in terms of the mean number of correct key presses per 30-s block (CKP/B). Consistent with previous research, participants made considerable improvements in CKP/B during the evening training sessions and between the end of training and the morning test sessions. Learners who listened to the model made significantly larger gains in performance during training and between the end of training and test than did those who did not hear the model.

Contribution of the Premotor Cortex to Consolidation of Motor Sequence Learning in Humans During Sleep

2010 ◽  
Vol 104 (5) ◽  
pp. 2603-2614 ◽  
Author(s):  
Michael A. Nitsche ◽  
Michaela Jakoubkova ◽  
Nivethida Thirugnanasambandam ◽  
Leonie Schmalfuss ◽  
Sandra Hullemann ◽  
...  
Keyword(s):  
Reaction Time ◽  
Task Performance ◽  
Rem Sleep ◽  
Sequence Learning ◽  
Memory Consolidation ◽  
Primary Motor Cortex ◽  
Premotor Cortex ◽  
Reaction Time Task ◽  
Motor Memory ◽  
Motor Sequence

Motor learning and memory consolidation require the contribution of different cortices. For motor sequence learning, the primary motor cortex is involved primarily in its acquisition. Premotor areas might be important for consolidation. In accordance, modulation of cortical excitability via transcranial DC stimulation (tDCS) during learning affects performance when applied to the primary motor cortex, but not premotor cortex. We aimed to explore whether premotor tDCS influences task performance during motor memory consolidation. The impact of excitability-enhancing, -diminishing, or placebo premotor tDCS during rapid eye movement (REM) sleep on recall in the serial reaction time task (SRTT) was explored in healthy humans. The motor task was learned in the evening. Recall was performed immediately after tDCS or the following morning. In two separate control experiments, excitability-enhancing premotor tDCS was performed 4 h after task learning during daytime or immediately before conduction of a simple reaction time task. Excitability-enhancing tDCS performed during REM sleep increased recall of the learned movement sequences, when tested immediately after stimulation. REM density was enhanced by excitability-increasing tDCS and reduced by inhibitory tDCS, but did not correlate with task performance. In the control experiments, tDCS did not improve performance. We conclude that the premotor cortex is involved in motor memory consolidation during REM sleep.

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