scholarly journals O031 Nocturnal melatonin secretion in post-treatment breast cancer patients: a preliminary study

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A14-A14
Author(s):  
H Subramanian ◽  
V Fuchsova ◽  
H Man ◽  
R Trivedi ◽  
E Elder ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sleep Quality ◽  
Cancer Patients ◽  
Post Treatment ◽  
Poor Sleep ◽  
Breast Cancer Patients ◽  
Melatonin Secretion ◽  
Poor Sleep Quality ◽  
Salivary Melatonin ◽  
Post Menopausal

Abstract Purpose Breast-cancer patients frequently report of poor sleep-quality. Although the pathophysiology is unclear, circadian-sleep misalignment is a plausible mechanism. We compared nocturnal melatonin-secretion, a circadian rhythm marker, in post-menopausal, post-treatment (≥12-months) female breast-cancer patients (BCG), with post-menopausal female controls with no history of cancer (CG) Methods We recruited 6 BCG and 10 CG from Westmead Hospital breast-cancer outpatient clinic or hospital-staff community, respectively. Participants completed the Pittsburgh Sleep Quality Index (PSQI; >5 PSQI-score=poor sleep-quality) and ~7 days of home-actigraphy (Philips Actiwatch-2, Philips Respironics, USA) to ascertain habitual bed-time (HBT). Later, participants completed an overnight, in-laboratory study, with saliva sampled (n=13) at regular intervals under strict dim-light conditions (<1 lux). Salivary-melatonin concentrations were quantified via radioimmunoassay (University of Adelaide). We measured 1) clock-time when salivary-melatonin concentrations reached 4pg/mL (melatonin onset-[DLMO-4pg/ml]) and 2) time-interval between HBT and DLMO-4pg/ml (indicates circadian-sleep misalignment-[PAR-DLMO]). Data were expressed as median [interquartile range], and compared using 2-sided Mann Whitney U-tests. p<0.05 was considered significant. Results BCG and CG had similar ages (62.5 [59.5–67.3] vs. 58.5 [54.0–66.3] yrs, respectively; p=0.23). Compared with CG, BCG had higher PSQI-scores (8.50 [5.25–10.75] vs. 4.00 [3.75–5.50] a.u.; p=0.07), but similar HBT (22:49 [21:46-23:38] vs. 22:17 [21:59-22:21] h:min; p=0.26). BCG had later DLMO-4pg/ml (20:46 [20:01-22:03] vs. 18:23 [17:55-20:07] h:min; p=0.03) and shorter PAR-DLMO (1.43 [0.96–2.38] vs. 3.63 [2.18–3.90] hrs; p=0.09), than CG. Conclusion Preliminary data indicate BCG had poorer sleep-quality, delayed melatonin onset, and altered circadian-sleep alignment; compared with CG. We speculate disrupted nocturnal melatonin-secretion potentially influences poor sleep-quality reported by breast-cancer patients.

scholarly journals Factors Affecting Sleep Quality of Breast Cancer Patients with Chemotherapy

2021 ◽  
Vol 9 (T4) ◽  
pp. 130-136
Author(s):  
Diyanah Syolihan Rinjani Putri ◽  
Sri Nabawiyati Nurul Makiyah
Keyword(s):  
Breast Cancer ◽  
Sleep Quality ◽  
Cancer Patients ◽  
Nuclear Family ◽  
Quality Data ◽  
Physiological Status ◽  
Poor Sleep ◽  
Breast Cancer Patients ◽  
Poor Sleep Quality ◽  
Correlation Test

BACKGROUND: Poor sleep quality becomes the effect of chemotherapy in breast cancer patients. AIM: This study aimed to examine the factors that influence breast cancer patients’ sleep quality undergoing chemotherapy. METHODS: This research used an observational method with cross-sectional design. There were 26 breast cancer patients undergoing chemotherapy at Djojonegoro Regional Hospital in Temanggung, Central Java. The characteristics of the respondent are recorded, including the demographic characteristics, respondents’ sleep quality, and the physiological status data of the respondent. The researchers use the Pittsburgh Sleep Quality Index (PSQI) to measure sleep quality. Data were analyzed using Kendall’s Tau and Spearman’s rank correlation test and the Pearson Product-Moment Correlation test. RESULTS: The result showed that breast cancer patients’ sleep quality is classified as poor with PSQI score of 10.96 ± 3.13. The average age of the respondent was 50.08 ± 7.31 years. The major characteristic of the respondent were 80.77% had married, 42.30% had elementary education, 61.54% did not work, and 61.54% had Rp 0, - income. Based on breast cancer patients undergoing chemotherapy, the respondents lived in rice field environment (42.30%), diagnosed with breast cancer <1 year (69.23%), had <1 year chemotherapy (96.15%), had under mastectomy on the left breast (80.76%), and underwent chemotherapy as much as 7.23 ± 4.80 times. Based on sleep quality, the respondents lived with nuclear family (61.54%), had no comorbidities (76.92%), did not consume other drugs (100%), did not consume sleeping pills (80.76%), and used lights during sleep (65.38%). There is a correlation between sleep quality and age and with whom the respondent lives in the same house. CONCLUSION: It was concluded that breast cancer patients undergoing chemotherapy had poor sleep quality, and the factors related to sleep quality were age and with whom the respondent lived in the same house.

scholarly journals Kualitas Tidur Pasien Kanker Payudara Berdasarkan Terapi yang Diberikan di RSUP DR. Hasan Sadikin Bandung

2017 ◽  
Vol 3 (2) ◽  
pp. 115
Author(s):  
Devita Alifiyanti ◽  
Yanti Hermayanti ◽  
Dyah Setyorini
Keyword(s):  
Breast Cancer ◽  
Sleep Quality ◽  
Cancer Patients ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Sampling Technique ◽  
Poor Sleep ◽  
Breast Cancer Patients ◽  
Consecutive Sampling

ABSTRAK  Tidur berkualitas dibutuhkan oleh pasien kanker payudara agar kondisi dan daya tahan tubuh dapat dipertahankan optimal. Pada saat tidur  sel yang rusak  dapat diperbaiki. Perawat harus memfasilitasi kebutuhan tersebut dan harus mengetahui kualitas tidur pasien dengan terapi yang berbeda, sebagai dasar perencanaan asuhan. Penelitian ini bertujuan untuk meggambarkan kondisi kualitas tidur pasien yang sedang menjalankan terapi di RSUP Dr. Hasan Sadikin Bandung. Penelitian ini menggunakan metode deskriptif kuantitatif dengan teknik consecutive sampling (n=31). Data dikumpulkan menggunakan kuesioner Pittsburgh Sleep Quality Index (PSQI). Kualitas tidur dikatakan baik bila skor total ≤ 5, dan kualitas tidur buruk bila skor total > 5. Hasil penelitian menunjukkan bahwa seluruh responden (100%) memiliki kualitas tidur yang buruk. Komponen yang paling banyak berkontribusi dalam penilaian tersebut adalah latensi tidur, durasi tidur, efisiensi kebiasaan tidur, dan disfungsi siang hari. Kualitas tidur terburuk dengan skor 18 terjadi pada responden yang menjalani radioterapi dengan mastektomi (2 orang) dan responden stadium lanjut (3 orang). Kesimpulan, bahwa terapi pengobatan yang dijalani dan kondisi kanker berkontribusi terhadap kualitas tidur pasien kanker payudara. Sejak pasien masuk perawat harus mengkaji kebutuhan tidur, menggali masalah kesulitan tidur, menjelaskan pengaruh tidur terhadap perbaikan sel, dan memberikan informasi tentang cara tidur berkualitas kepada pasien dan keluarganya untuk setting rumah sakit dan di rumah. Rumah Sakit harus memfasilitasi kebutuhan pasien agar tidak terganggu saat tertidur selama dalam perawatan.  ABSTRACT Deep sleep is needed by breast cancer patients to maintain health quality  optimally.  During that time the damaged cells can be repair. Nurses should facilitate the need and should know the sleep quality as the basis for nursing care. This study aims to describe  sleep quality of breast cancer patients with the treatmen at Dr. Hasan Sadikin Bandung.  This research uses quantitative descriptive method with consecutive sampling technique (n = 31). Data were collected using the Pittsburgh Sleep Quality Index (PSQI). Sleep quality was good when the total score ≤5.  Sleep quality was  poor when the total score >5. The results show that all respondents (100%) had poor sleep quality. The components which contribute to the condition were sleep latency, sleep duration, sleep efficiency and daytime dysfunction. The worst score sleep quality was 18 which occurred on mastectomy patient with radiotherapy (2) and  advanced stage patients (3).  To  conclude that treatment for cancer contribute to sleep quality of breast cancer patients.  Nurses should assess the needs of sleep, explore the problem of sleeping difficulties, explain the effect of sleep on cell repair, and provide information about  getting a good sleep at the  hospital or home settings. Hospital should  facilitate  the infrastructure to full fill tne  need.  

scholarly journals The Sleep Quality of Breast Cancer Patients

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Devita Alifiyanti ◽  
Yanti Hermayanti ◽  
Dyah Setyorini
Keyword(s):  
Breast Cancer ◽  
Sleep Quality ◽  
Cancer Patients ◽  
Sampling Technique ◽  
The Body ◽  
Poor Sleep ◽  
Immune Functions ◽  
Breast Cancer Patients ◽  
Quality Of Sleep

The quality of sleep is required by breast cancer patients to regenerate and repair the body cells. When patients’ sleep is disturbed, it may be affected to the physiological conditions, such as decreased appetite, weight loss, anxiety, irritability, and changes in natural and cellular immune functions. Breast cancer therapies can affect the quality of sleep. This study aimed to determine the sleep quality of breast cancer patients that had treatments in a public hospital in Bandung. This research used the quantitative descriptive approach. The sample was selected using the consecutive sampling technique (n = 31). Data were collected using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Sleep quality was categorized as good when the total score was ≤ 5, and sleep quality was poor when the total score was > 5. The results of this study indicated that all respondents (100%) had poor sleep quality. The components that contributed to the assessment were sleep latency, sleep duration, sleep efficiency, and daytime dysfunction. The worst sleep quality with the highest score (18) occurred in respondents who had radiotherapy and mastectomy (2 persons), and respondents in advanced stage (3 persons). This study concludes that the pharmacological therapies and the stages of cancer contributed to the sleep quality of breast cancer patients. It is expected that health professionals and hospitals notice the patient’s sleeping needs during treatment at the hospital.

scholarly journals KUALITAS TIDUR PASIEN KANKER PAYUDARA YANG MENJALANI KEMOTERAPI

2020 ◽  
Vol 16 (2) ◽  
pp. 91
Author(s):  
Dian Anggraini ◽  
Dewi Marfuah ◽  
Susy Puspasari
Keyword(s):  
Breast Cancer ◽  
Immune System ◽  
Sleep Quality ◽  
Cancer Patients ◽  
Univariate Analysis ◽  
Sampling Technique ◽  
Poor Sleep ◽  
Breast Cancer Patients ◽  
The Impact

Background : In the last five years, the prevalence of breast cancer in Indonesia has increased. The usual treatment for breast cancer is chemotherapy, which can cause physical problems that affect sleep quality. Sleep disorders are often experienced by breast cancer patients, where the impact affects the healing of the cancer and the immune system so that the condition and immune system cannot be maintained optimally in repairing body cells. Purpose: to determine the quality of sleep in breast cancer patients undergoing chemotherapy and to see which components have contributed to disturbing sleep quality. Methods: The study used a quantitative descriptive approach. Sampling technique accidental sampling with 100 respondent. The questionnaire used to measure sleep quality was the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The data analysis technique used univariate analysis, there are two interpretations on the PSQI. Sleep quality is good if the score is ≤ 5, sleep quality is bad if the score is> 5. Results: Most of the respondents have poor sleep quality. This research is expected to increase the role of nursing care and educator so that it can improve the quality of life of breast cancer patients undergoing chemotherapy

scholarly journals Effect of yoga on sleep quality and neuroendocrine immune response in metastatic breast cancer patients

2017 ◽  
Vol 23 (3) ◽  
pp. 253 ◽  
Author(s):  
RaghavendraMohan Rao ◽  
HS Vadiraja ◽  
R Nagaratna ◽  
KS Gopinath ◽  
Shekhar Patil ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immune Response ◽  
Metastatic Breast Cancer ◽  
Sleep Quality ◽  
Cancer Patients ◽  
Metastatic Breast ◽  
Breast Cancer Patients
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