When Bonding Fails: Clinical Assessment of High Risk Families. By Frank G. Bolton, Jr. Beverly Hills, Calif.: Sage Publications, 1983. 224 pp. $28.00 cloth, $14.00 paper

A substantial fraction of familial ovarian cancer cases cannot be attributed to specific genetic factors. The discovery of additional susceptibility genes will permit a more accurate assessment of hereditary cancer risk and allow for monitoring of predisposed women in order to intervene at the earliest possible stage. We focused on a population with elevated familial breast and ovarian cancer risk. In this study, we identified a SNP rs926103 whose minor allele is associated with predisposition to ovarian but not breast cancer in a Caucasian high-risk population without BRCA1/ BRCA2 mutations. We have found that the allelic variation of rs926103, which alters amino acid 52 of the encoded protein SH2D2A/TSAd, results in differences in the activity of this protein involved in multiple signal transduction pathways, including regulation of immune response, tumor vascularization, cell growth, and differentiation. Our observation provides a novel candidate genetic biomarker of elevated ovarian cancer risk in members of high-risk families without BRCA1/2 mutations, as well as a potential therapeutic target, TSAd.

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Prenatal Diagnosis of Congenital Nephrosis in 23 High-Risk Families

Archives of Pediatrics and Adolescent Medicine ◽

10.1001/archpedi.1978.02120350048008 ◽

1978 ◽

Vol 132 (10) ◽

pp. 984

Author(s):

Pertti Aula

Keyword(s):

Prenatal Diagnosis ◽

High Risk ◽

Congenital Nephrosis ◽

High Risk Families

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Prostate cancer screening in high risk families: higher detection in first degree relatives even in families without obvious hereditary patterns

European Urology Supplements ◽

10.1016/s1569-9056(02)80286-x ◽

2002 ◽

Vol 1 (1) ◽

pp. 75

Author(s):

A. Valerie ◽

L. Cormier ◽

M.P. Moineu ◽

G. Cancel-Tassin ◽

R. Azzouzi ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Screening ◽

High Risk ◽

Prostate Cancer Screening ◽

First Degree Relatives ◽

Hereditary Patterns ◽

High Risk Families

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Mutation detection rates associated with specific selection criteria for BRCA1/2 testing in 1854 high-risk families: A monocentric Italian study

European Journal of Internal Medicine ◽

10.1016/j.ejim.2016.03.010 ◽

2016 ◽

Vol 32 ◽

pp. 65-71 ◽

Cited By ~ 11

Author(s):

Jacopo Azzollini ◽

Giulietta Scuvera ◽

Eleonora Bruno ◽

Patrizia Pasanisi ◽

Daniela Zaffaroni ◽

...

Keyword(s):

High Risk ◽

Selection Criteria ◽

Mutation Detection ◽

Detection Rates ◽

Italian Study ◽

High Risk Families

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Using the Case Method to Develop Critical Thinking Skills for the Care of High-Risk Families

Journal of Family Nursing ◽

10.1177/107484079900500106 ◽

1999 ◽

Vol 5 (1) ◽

pp. 92-109 ◽

Cited By ~ 10

Author(s):

Gail Holland Wade

Keyword(s):

Critical Thinking ◽

High Risk ◽

Thinking Skills ◽

Critical Thinking Skills ◽

Case Method ◽

High Risk Families

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Principles of nutritional support

Current Surgical Guidelines ◽

10.1093/med/9780198794769.003.0022 ◽

2018 ◽

pp. 199-206

Author(s):

Abdullah Jibawi ◽

Mohamed Baguneid ◽

Arnab Bhowmick

Keyword(s):

Risk Factor ◽

High Risk ◽

Parenteral Nutrition ◽

Clinical Assessment ◽

Nutritional Support ◽

Length Of Hospital Stay ◽

Screening Methods ◽

Hospital Patients ◽

Lower Infection ◽

Malnutrition Universal Screening Tool

Malnutrition is a commonly found risk factor in hospitalized patients. All hospital patients, especially the high-risk ones, should be offered nutritional screening. Methods of screening include MUST (Malnutrition Universal Screening Tool) and the patient should have a thorough clinical assessment and investigations. The patient should meet adequate calorie requirement either by oral or enteral or parenteral nutrition. Malnourished patients receiving nutrition supplements demonstrated lower infection rates and shorter length of hospital stay compared to no supplements.

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