scholarly journals Metallothionein-1 and -2 Expression in Cadmium- or Arsenic-Derived Human Malignant Urothelial Cells and Tumor Heterotransplants and as a Prognostic Indicator in Human Bladder Cancer

2006 ◽  
Vol 91 (2) ◽  
pp. 467-475 ◽  
Author(s):  
Xu Dong Zhou ◽  
Donald A. Sens ◽  
Mary Ann Sens ◽  
Venugopal B. R. K. Namburi ◽  
Rajendra K. Singh ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Indicator ◽  
Human Bladder Cancer ◽  
Urothelial Cells ◽  
Human Bladder

883: The Anticancer Activity of Mycobacterial Cell Wall-DNA Complex (MCC) Against Human Bladder Cancer Cell Lines is Different to BCG

2007 ◽  
Vol 177 (4S) ◽  
pp. 294-294
Author(s):  
Nigel C. Phillips ◽  
Sonia Ménard ◽  
David S. Surprenant ◽  
Danbing Ke ◽  
Mario C. Filion
Keyword(s):  
Bladder Cancer ◽  
Cell Wall ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Human Bladder Cancer Cell ◽  
Mycobacterial Cell Wall ◽  
Dna Complex

776: Enhanced Radiosensitivity by Inhibition of the Antiapoptotic Gene Clusterin Using Antisense Oligodeoxynucleotide in a Human Bladder Cancer Model

2005 ◽  
Vol 173 (4S) ◽  
pp. 210-211
Author(s):  
Kazuki Yamanaka ◽  
Hideaki Miyake ◽  
Mototsugu Muramaki ◽  
Sadao Kamidono ◽  
Martin E. Gleave ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Antisense Oligodeoxynucleotide ◽  
Human Bladder Cancer ◽  
Cancer Model ◽  
Human Bladder ◽  
Antiapoptotic Gene ◽  
Bladder Cancer Model

972: Antisense CK2 Gene Therapy Induces Regression in Human Bladder Cancer Growing in Athymic Nude Mice

2004 ◽  
Vol 171 (4S) ◽  
pp. 257-258
Author(s):  
Joel Slaton ◽  
Daniel Sloper ◽  
Miriam Taylor ◽  
Alan Davis ◽  
Khalil Ahmed
Keyword(s):  
Gene Therapy ◽  
Bladder Cancer ◽  
Nude Mice ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Athymic Nude Mice

968: Gelsolin Gene Silencing Involving Unusual Chromatin Structures and a Novel Stem Loop Structure of the Promoter Region in Human Bladder Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 256-257
Author(s):  
Kazunori Haga ◽  
Ataru Sazawa ◽  
Toru Harabayashi ◽  
Nobuo Shinohara ◽  
Minoru Nomoto ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Gene Silencing ◽  
Promoter Region ◽  
Loop Structure ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Stem Loop ◽  
Stem Loop Structure

scholarly journals Changes in Tumor Growth and Metastatic Capacities of J82 Human Bladder Cancer Cells Suppressed by Down-Regulation of Calreticulin Expression

2011 ◽  
Vol 179 (3) ◽  
pp. 1425-1433 ◽  
Author(s):  
Yi-Chien Lu ◽  
Chiung-Nien Chen ◽  
Bojeng Wang ◽  
Wen-Ming Hsu ◽  
Szu-Ta Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Human Bladder Cancer ◽  
Down Regulation ◽  
Human Bladder ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells

Autophagy promotes oncolysis of an adenovirus expressing apoptin in human bladder cancer models

2021 ◽  
Author(s):  
Chao Shang ◽  
Yi-Long Zhu ◽  
Yi-Quan Li ◽  
Gao-Jie Song ◽  
Chen-Chen Ge ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Cancer Models

scholarly journals LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Liping Shan ◽  
Wei Liu ◽  
Yunhong Zhan
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Noncoding Rna ◽  
Caspase 3 ◽  
Retinoic Acid Receptor ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Link Type ◽  
Retinoic Acid Receptor Beta ◽  
Receptor Beta

Abstract Background Growing evidence has shown that long noncoding RNA: microRNA: mRNA is implicated in tumor initiation, development, and progression. Long noncoding RNA HAND2-AS1 exhibits anti-cancer effects in diverse cancers. However, the knowledge of HAND-AS1 in bladder cancer development remains unknown. Methods LncRNA and miRNA microarray was conducted to explore different expressed RNA in primary bladder cancer specimens. RNA-RNA interaction prediction tools miRcode (http://www.mircode.org/), DIANA-lncBase v2 (https://carolina.imis.athena-innovation.gr/diana_tools/web/index.php?r=lncbasev2%2Findex-experimental), DIANA-TarBase v.8 (https://carolina.imis.athena-innovation.gr/diana_tools/web/index.php?r=tarbasev8%2Findex) and miRDB (http://www.mirdb.org/) were employed to predict the interactions between RNA. Bladder cancer cell lines were used to perform cell proliferation and apoptosis assays. Western blot and quantitative Real-time Polymerase Chain Reaction were used to determine the expression of protein and RNA separately. Dual-luciferase assay was conducted to determine the activity of three prime untranslated region of retinoic acid receptor beta (RARB). Furthermore, 5637 human bladder cancer mouse models were established to investigate the interactions of lncRNA: miRNA: mRNA in vivo. Results Based on the RT2 lncRNA PCR Arrays analysis, we validated HAND2-AS1 declined in bladder cancer and negatively correlated with the depth of invasion and grades. The overexpression of HAND2-AS1 in human bladder cancer cells 5637 and RT4 hampered cell proliferation by provoking Caspase 3-triggered cell apoptosis. Besides, one of the HAND2-AS1 sponges, miR-146, elevated in bladder cancer and targeted the tumor suppressor, retinoic acid receptor beta (RARB). We further demonstrated that the HAND2-AS1: miR-146: RARB complex promoted Caspase 3-mediated apoptosis by suppressing COX-2 expression. Finally, the results gained in mouse xenografts suggested that HAND2-AS1 diminished miR-146 expression, thereby reversing the suppression of miR-146 on RARB-mediated apoptosis and contributing to bladder cancer regression. Conclusion The present study sheds light on the fact that lncRNA HAND2-AS1 exerted as a tumor suppressor by releasing RARB from miR-146, leading to tumor proliferation and invasion inhibition. The findings expanded HAND2-AS-mediated regulatory networks' knowledge and provided novel insights to improve the RARB-targeted regimens against bladder cancer.

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