scholarly journals Lead Exposure: Expression and Activity Levels of Oct-2 in the Developing Rat Brain

2006 ◽  
Vol 95 (2) ◽  
pp. 436-442 ◽  
Author(s):  
S. A. Bakheet ◽  
Md. R. Basha ◽  
H. Cai ◽  
N. H. Zawia
Keyword(s):  
Rat Brain ◽  
Lead Exposure ◽  
Activity Levels ◽  
Developing Rat ◽  
Expression And Activity

Experimental Manipulation of Acetylcholine Levels in Developing Rat Brain: Neurochemistry and Behavior

1979 ◽  
Vol 45 (3) ◽  
pp. 811-818 ◽  
Author(s):  
C. B. Mathura ◽  
G. W. Meier ◽  
W. A. Himwich
Keyword(s):  
Rat Brain ◽  
Rapid Development ◽  
Experimental Manipulation ◽  
Activity Levels ◽  
Dose Response Relationship ◽  
Behavioral Measures ◽  
And Behavior ◽  
And Control ◽  
Developing Rat ◽  
Drug Manipulation

An attempt was made to manipulate experimentally the acetylcholine (ACh) system during rapid development of the rat brain. Developmental periods of ACh manipulated were 2 to 15 days and 15 to 28 days postnatally. The findings showed that the highest level of drug manipulation .75 mg/kg physostigmine and, .025 mg/kg methscopolamine significantly produced the highest level of ACh, lowest activity levels of both acetylcholinesterase (AChE) and choline acetyltransferease (ChAc) as compared to the intermediate, and control doses. This dose-response relationship was obtained in the animals injected over a 15- to 28-day period during the period of maximal growth of the acetylcholine system. These statistically significant differences measured at 24 hr. after injection support the thesis that injections during the critical period of development produce longer lasting effects than if administered at other periods. Behavioral measures, GO:NO-GO discrimination avoidance tasks, were also both significantly related to the highest dose group yet were not differentiated to developmental periods of injections.

Regulation of tubulin by triiodothyronine in hypothyroid rat brain

1985 ◽  
Vol 5 (8) ◽  
pp. 643-648 ◽  
Author(s):  
Anjana Mazumder ◽  
Kamal Das ◽  
Pranab K. Sarkar
Keyword(s):  
Protein Synthesis ◽  
Rat Brain ◽  
Brain Maturation ◽  
Normal Brain ◽  
Neonatal Brain ◽  
Organ Cultures ◽  
Postnatal Brain ◽  
Enhanced Sensitivity ◽  
Brain Exposure ◽  
Developing Rat

The effect of T3 (triiodothyronine) on the induction of tubulin in hypothyroid developing rat brain has been examined using organ cultures of brains from late fetal, neonatal and postnatalrats. The neonatal brain displayed maximum sensitivity to T3. Hypothyroidism resulted in a 26% decline in the level of tubulin in the neonatal brain as opposed to a 5–15% decline in the fetal or postnatal brain. Exposure of the hypothyroi d neonatal brain to T3 for 2 h in culture led to a 61% rise in the level of tubulin in contrast to a 41% increase seen in the case of normal brain. Total protein synthesis was not significantly affected. The preferential decline of tubulin in the neonatal hypothyroid brain, its enhanced sensitivity to T3 compared to normal brain, and the coincidence of the period of sensitivity to that of brain maturation indicate that the regulation of the level of tubulin by T3 in the developing brain is a natural ontogenic phenomenon.

scholarly journals Effect of Hypoxic-Ischemic Injury on Serine Palmitoyltransferase Activity in the Developing Rat Brain

Pathobiology ◽  
2008 ◽  
Vol 75 (6) ◽  
pp. 330-334 ◽  
Author(s):  
Masaki Daigo ◽  
Yasuhiro Arai ◽  
Kyoichi Oshida ◽  
Yohei Kitamura ◽  
Masaharu Hayashi ◽  
...  
Keyword(s):  
Rat Brain ◽  
Ischemic Injury ◽  
Serine Palmitoyltransferase ◽  
Developing Rat ◽  
Hypoxic Ischemic Injury
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