scholarly journals Oral Propylparaben Administration to Juvenile Male Wistar Rats Did Not Induce Toxicity in Reproductive Organs

2013 ◽  
Vol 136 (2) ◽  
pp. 392-401 ◽  
Author(s):  
Vincent Gazin ◽  
Edward Marsden ◽  
Fabien Marguerite
2016 ◽  
Vol 175 (2) ◽  
pp. 367-374 ◽  
Author(s):  
Alexey A. Tinkov ◽  
Eugenia R. Gatiatulina ◽  
Elizaveta V. Popova ◽  
Valentina S. Polyakova ◽  
Anastasia A. Skalnaya ◽  
...  

1990 ◽  
Vol 52 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Dipak K. Giri ◽  
Manas K. Chaudhuri ◽  
Radhika Jayashankar ◽  
G.S. Neelaram ◽  
S. Jayaraman ◽  
...  

2010 ◽  
Vol 82 (4) ◽  
pp. 907-914 ◽  
Author(s):  
Leda M.F. Lucinda ◽  
Camila B. Rocha ◽  
Maycon M. Reboredo ◽  
Vinícius C. Faria ◽  
Rita C.S. Sá

Caesalpinia ferrea Mart (Leguminosae) is a medicinal plant used to treat diabetes, among other therapeutic properties, but which is also reported to have hepatotoxic effects. Although it contains substances such as flavonoids and coumarin, which are known to have antifertility activity, no studies have apparently been conducted to evaluate the potential adverse side effects of this plant on the function of the reproductive system after a chronic treatment. Therefore, this investigation was carried out to evaluate the effect and safety of the long-term exposure to C. ferrea on male Wistar rats' vital organs, reproductive system and sperm production. Adult and immature male rats were treated with an aqueous extract of C. ferrea at a dose level of 300 mg/kg of body weight, administered during one or two spermatogenic cycles of this species. The reproductive and vital organs were analyzed, and sperm was collected from the epididymal secretion of the right epididymis cauda. The long-term administration of C. ferrea did not significantly alter the body, vital and reproductive organs weights. Gamete production was not affected either. The chronic assessment of C. ferrea suggests that this plant does not affect the normal functioning of the Wistar rat reproductive system.


Author(s):  
Manokaran Kalaivani ◽  
Ummer Velladath Saleena ◽  
Karthik Ganapathi Kamath Katapadi ◽  
Yekula Praveen Kumar ◽  
Deepak Nayak ◽  
...  

Contraception ◽  
2003 ◽  
Vol 67 (4) ◽  
pp. 327-331 ◽  
Author(s):  
Rita de Cássia da Silveira e Sá ◽  
Magda Narciso Leite ◽  
Maycon de Moura Reporedo ◽  
Reinaldo Nóbrega de Almeida

Author(s):  
O. R. Asuquo ◽  
T. B. Ekanem ◽  
O. O. K Oko ◽  
M. A. Eluwa

Background: Spondias mombin is one of the tropical plants used locally to treat various kinds of ailment, its use as an anti-conceptive remedy in our locality had been reported. Objective: The aim of this study was to establish a dose-dependent or duration effect of ethanolic leaf extract of Spondias mombin on the anterior pituitary cells, testes and epididymides of Wistar rats of Wistar rats. Materials and Methods: A total of thirty (30) matured male Wistar rats were randomly divided into five groups (n=5). Group 1 animals served as control and received vehicle (distilled water). Groups 2 and 3 were administered with 250 mgkg-1 body weight of extract for 4 and 6 weeks respectively, while groups 4 and 5 received 500 mgkg-1 body weight of extract for 4 and 6 weeks also.  Animals were anaesthetized with chloroform and sacrificed at the end of the administration. Body weight, weights of reproductive organs and vital organs were evaluated. Blood was taken from the animals for haematological and biochemical analysis. The pituitary gland, male reproductive and accessory glands were excised and fixed in 10% formalin for routine histological examination. Results: The influence of ethanolic extract of Spondias mombin leaves on the pituitary cells and reproductive organs of male Wistar rats given 250 and 500 mgkg-1 body weight for 4 and 6 weeks showed loss of cytoplasmic contents and free spaces of pituitary cells, desquamation of seminiferous epithelial cells, degradation of seminiferous tubules and reduction in cells. The epididymis of the test groups showed abundant immature cells and cell debris in their lumen. The accessory glands showed homogenous pinkish fluid, glandular degeneration of the prostate and seminal vesicles with decreased structural integrity. The organ weights of the experimental animals were not significantly affected, however, a significant (P<0.05) decrease in reproductive organ weights was recorded. Ethanolic extract of Spondias mombin on liver enzymes showed significant protection against hepatobiliary damage.  Conclusion: These results suggest that Spondias mombin has a dose-dependent and duration deleterious effect on the pituitary and reproductive organs at their cellular levels rather than on the tissue as a whole.


Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.


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