scholarly journals P-Glycoprotein on Blood-Brain Barrier Plays a Vital Role in Fentanyl Brain Exposure and Respiratory Toxicity in Rats

2018 ◽  
Vol 164 (1) ◽  
pp. 353-362 ◽  
Author(s):  
Chenchen Yu ◽  
Mei Yuan ◽  
Haiying Yang ◽  
Xiaomei Zhuang ◽  
Hua Li
Keyword(s):  
Blood Brain Barrier ◽  
Vital Role ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Brain Exposure ◽  
Respiratory Toxicity

Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood–brain barrier in mice

2012 ◽  
Vol 40 (12) ◽  
pp. 3215-3223 ◽  
Author(s):  
Hisham Alhaddad ◽  
Salvatore Cisternino ◽  
Xavier Declèves ◽  
Nicolas Tournier ◽  
Joel Schlatter ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Respiratory Toxicity

scholarly journals Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration

2008 ◽  
Vol 37 (3) ◽  
pp. 529-535 ◽  
Author(s):  
Rong Zhao ◽  
J. Cory Kalvass ◽  
Souzan B. Yanni ◽  
Arlene S. Bridges ◽  
Gary M. Pollack
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Brain Exposure

The influence of mass of [11C]-laniquidar and [11C]-N-desmethyl-loperamide on P-glycoprotein blockage at the blood–brain barrier

2012 ◽  
Vol 39 (1) ◽  
pp. 121-125 ◽  
Author(s):  
Lieselotte Moerman ◽  
Caroline Dumolyn ◽  
Paul Boon ◽  
Filip De Vos
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain

scholarly journals Pseudogene ACTBP2 increases blood–brain barrier permeability by promoting KHDRBS2 transcription through recruitment of KMT2D/WDR5 in Aβ1–42 microenvironment

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Qianshuo Liu ◽  
Xiaobai Liu ◽  
Defeng Zhao ◽  
Xuelei Ruan ◽  
Rui Su ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Molecular Mechanisms ◽  
Rna Binding ◽  
Vital Role ◽  
Brain Barrier ◽  
Blood Brain ◽  
Bbb Permeability ◽  
Novel Target ◽  
And Function

AbstractThe blood–brain barrier (BBB) has a vital role in maintaining the homeostasis of the central nervous system (CNS). Changes in the structure and function of BBB can accelerate Alzheimer’s disease (AD) development. β-Amyloid (Aβ) deposition is the major pathological event of AD. We elucidated the function and possible molecular mechanisms of the effect of pseudogene ACTBP2 on the permeability of BBB in Aβ1–42 microenvironment. BBB model treated with Aβ1–42 for 48 h were used to simulate Aβ-mediated BBB dysfunction in AD. We proved that pseudogene ACTBP2, RNA-binding protein KHDRBS2, and transcription factor HEY2 are highly expressed in ECs that were obtained in a BBB model in vitro in Aβ1–42 microenvironment. In Aβ1–42-incubated ECs, ACTBP2 recruits methyltransferases KMT2D and WDR5, binds to KHDRBS2 promoter, and promotes KHDRBS2 transcription. The interaction of KHDRBS2 with the 3′UTR of HEY2 mRNA increases the stability of HEY2 and promotes its expression. HEY2 increases BBB permeability in Aβ1–42 microenvironment by transcriptionally inhibiting the expression of ZO-1, occludin, and claudin-5. We confirmed that knocking down of Khdrbs2 or Hey2 increased the expression levels of ZO-1, occludin, and claudin-5 in APP/PS1 mice brain microvessels. ACTBP2/KHDRBS2/HEY2 axis has a crucial role in the regulation of BBB permeability in Aβ1–42 microenvironment, which may provide a novel target for the therapy of AD.

The Strongest Expression of P-Glycoprotein is in the Blood-Brain Barrier

1996 ◽  
pp. 171-174 ◽  
Author(s):  
Edith Beaulieu ◽  
Michel Demeule ◽  
Diana A. Averill-Bates ◽  
Richard Béliveau
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain
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