scholarly journals Minimally Invasive Autopsy: Welcoming a New Tool for Cause of Death Investigation in Children in Resource-constrained Countries

2017 ◽  
Vol 63 (4) ◽  
pp. 249-252 ◽  
Author(s):  
Quique Bassat
Keyword(s):  
Minimally Invasive ◽  
Cause Of Death ◽  
Resource Constrained ◽  
Minimally Invasive Autopsy ◽  
Death Investigation

scholarly journals Minimally Invasive Autopsy Practice in COVID-19 Cases: Biosafety and Findings

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 412
Author(s):  
Natalia Rakislova ◽  
Lorena Marimon ◽  
Mamudo R. Ismail ◽  
Carla Carrilho ◽  
Fabiola Fernandes ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Cause Of Death ◽  
Diffuse Alveolar Damage ◽  
The Body ◽  
Protective Equipment ◽  
Safe Alternative ◽  
Minimally Invasive Autopsy ◽  
Postmortem Studies ◽  
Death Investigation ◽  
Insight Into

Postmortem studies are crucial for providing insight into emergent diseases. However, a complete autopsy is frequently not feasible in highly transmissible diseases due to biohazard challenges. Minimally invasive autopsy (MIA) is a needle-based approach aimed at collecting samples of key organs without opening the body, which may be a valid alternative in these cases. We aimed to: a) provide biosafety guidelines for conducting MIAs in COVID-19 cases, b) compare the performance of MIA versus complete autopsy, and c) evaluate the safety of the procedure. Between October and December 2020, MIAs were conducted in six deceased patients with PCR-confirmed COVID-19, in a basic autopsy room, with reinforced personal protective equipment. Samples from the lungs and key organs were successfully obtained in all cases. A complete autopsy was performed on the same body immediately after the MIA. The diagnoses of the MIA matched those of the complete autopsy. In four patients, COVID-19 was the main cause of death, being responsible for the different stages of diffuse alveolar damage. No COVID-19 infection was detected in the personnel performing the MIAs or complete autopsies. In conclusion, MIA might be a feasible, adequate and safe alternative for cause of death investigation in COVID-19 cases.

scholarly journals Assessing viability of a minimally invasive autopsy technique in ascertaining the probable cause of death in patients who were SARS CoV19 positive at the time of their demise

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ajay H. Bhandarwar ◽  
Girish D. Bakhshi ◽  
Eham Arora ◽  
Nikhil Dhimole ◽  
Sanjay R. Bijwe ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Cause Of Death ◽  
Histopathological Examination ◽  
Health Hazard ◽  
World Health ◽  
Invasive Technique ◽  
Tissue Samples ◽  
Conventional Autopsy ◽  
Minimally Invasive Autopsy ◽  
Health Organization

Abstract Background SARS CoV-19 was declared as a pandemic by the World Health Organization (WHO), raising up challenges on various levels ranging from therapeutics to diagnostics. The conventional autopsy technique may pose a health hazard to health care workers. A minimally invasive autopsy technique can diminish this hazard. Materials and methods Between August and November 2020, 51 patients who were suffering from Covid-19 at the time of their demise were included. A novel minimally invasive ultrasound-guided technique for procuring tissue samples of major organs was employed which were thereafter subject to histopathological examination. A detailed review of the course in hospital was noted. An analysis was performed to correlate the cause of death ascertained from our minimally invasive technique with the cause of death ascertained clinically. Results There was adequate tissue sampling in 45 cases, where the minimally invasive autopsy technique confirmed the cause of death in all 45 cases (100%) and made it more specific in 5 cases (11.11%). Conclusion Minimally Invasive Autopsy is an easily reproducible technique which has the potential to strengthen the probable the cause of death with reasonable certainty while ensuring safety and ethics.

scholarly journals Minimally invasive autopsy for fetuses and children based on a combination of post-mortem MRI and endoscopic examination: a feasibility study

2019 ◽  
Vol 23 (46) ◽  
pp. 1-104 ◽  
Author(s):  
Celine Lewis ◽  
John C Hutchinson ◽  
Megan Riddington ◽  
Melissa Hill ◽  
Owen J Arthurs ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Cause Of Death ◽  
Clinical Indication ◽  
Religious Leaders ◽  
Training Requirements ◽  
Less Invasive ◽  
Sudden Unexplained Death ◽  
Unexplained Death ◽  
Minimally Invasive Autopsy ◽  
Autopsy Data

BackgroundLess invasive perinatal and paediatric autopsy methods, such as imaging alongside targeted endoscopy and organ biopsy, may address declining consent rates for traditional autopsy, but their acceptability and accuracy are not known.ObjectivesThe aims of this study were to provide empirical data on the acceptability and likely uptake for different types of autopsy among key stakeholders (study 1); and to analyse existing autopsy data sources to provide estimates of the potential efficacy of less invasive autopsy (LIA) and its projected utility in clinical practice (study 2).Review methodsStudy 1: this was a mixed-methods study. Parents were involved in research design and interpretation of findings. Substudy 1: a cross-sectional survey of 859 parents who had experienced miscarriage, termination of pregnancy for fetal anomaly, stillbirth, infant or child death, and interviews with 20 responders. Substudy 2: interviews with 25 health professionals and four coroners. Substudy 3: interviews with 16 religious leaders and eight focus groups, with 76 members of the Muslim and Jewish community. Study 2: a retrospective analysis of national data in addition to detailed information from an existing in-house autopsy database of > 5000 clinical cases that had undergone standard autopsy to determine the proportion of cases by clinical indication group for which tissue sampling of specific internal organs significantly contributed to the diagnosis.ResultsSubstudy 1: 91% of participants indicated that they would consent to some form of LIA, 54% would consent to standard autopsy, 74% to minimally invasive autopsy (MIA) and 77% to non-invasive autopsy (NIA). Substudy 2: participants viewed LIA as a positive development, but had concerns around the limitations of the technology and de-skilling the workforce. Cost implications, skills and training requirements were identified as implementation challenges. Substudy 3: religious leaders agreed that NIA was religiously permissible, but MIA was considered less acceptable. Community members indicated that they might consent to NIA if the body could be returned for burial within 24 hours. Study 2: in 5–10% of cases of sudden unexplained death in childhood and sudden unexplained death in infants, the final cause of death is determined by routine histological sampling of macroscopically normal organs, predominantly the heart and lungs, and in this group routine histological sampling therefore remains an important aspect of investigation. In contrast, routine histological examination of macroscopically normal organs rarely (< 0.5%) provides the cause of death in fetal cases, making LIA and NIA approaches potentially highly applicable.LimitationsA key limitation of the empirical research is that it is hypothetical. Further research is required to determine actual uptake. Furthermore, because of the retrospective nature of the autopsy data set, findings regarding the likely contribution of organ sampling to final diagnosis are based on extrapolation of findings from historical autopsies, and prospective data collection is required to validate the conclusions.ConclusionsLIA is viable and acceptable (except for unexplained deaths), and likely to increase uptake. Further health economic, performance and implementation studies are required to determine the optimal service configuration required to offer this as routine clinical care.FundingThe National Institute for Health Research Health Technology Assessment programme.

scholarly journals Willingness to Know the Cause of Death and Hypothetical Acceptability of the Minimally Invasive Autopsy in Six Diverse African and Asian Settings: A Mixed Methods Socio-Behavioural Study

PLoS Medicine ◽  
2016 ◽  
Vol 13 (11) ◽  
pp. e1002172 ◽  
Author(s):  
Maria Maixenchs ◽  
Rui Anselmo ◽  
Emily Zielinski-Gutiérrez ◽  
Frank O. Odhiambo ◽  
Clarah Akello ◽  
...  
Keyword(s):  
Mixed Methods ◽  
Minimally Invasive ◽  
Cause Of Death ◽  
Behavioural Study ◽  
Minimally Invasive Autopsy

Performance of the Minimally Invasive Autopsy Tool for Cause of Death Determination in Adults Deaths from the Brazilian Amazon: An Observational Study

2019 ◽  
Author(s):  
Antonio E. M. Palhares ◽  
Luiz Carlos de Lima Ferreira ◽  
Monique Freire ◽  
Paola Castillo ◽  
Miguel J. Martínez ◽  
...  
Keyword(s):  
Observational Study ◽  
Minimally Invasive ◽  
Cause Of Death ◽  
Brazilian Amazon ◽  
Minimally Invasive Autopsy ◽  
Death Determination

scholarly journals Performance of the minimally invasive autopsy tool for cause of death determination in adult deaths from the Brazilian Amazon: an observational study

2019 ◽  
Vol 475 (5) ◽  
pp. 649-658 ◽  
Author(s):  
Antonio E. M. Palhares ◽  
Luiz Ferreira ◽  
Monique Freire ◽  
Paola Castillo ◽  
Miguel J Martínez ◽  
...  
Keyword(s):  
Observational Study ◽  
Minimally Invasive ◽  
Cause Of Death ◽  
Brazilian Amazon ◽  
Minimally Invasive Autopsy ◽  
Death Determination

scholarly journals Validity of a Minimally Invasive Autopsy for Cause of Death Determination in Adults in Mozambique: An Observational Study

PLoS Medicine ◽  
2016 ◽  
Vol 13 (11) ◽  
pp. e1002171 ◽  
Author(s):  
Paola Castillo ◽  
Miguel J. Martínez ◽  
Esperança Ussene ◽  
Dercio Jordao ◽  
Lucilia Lovane ◽  
...  
Keyword(s):  
Observational Study ◽  
Minimally Invasive ◽  
Cause Of Death ◽  
Minimally Invasive Autopsy ◽  
Death Determination

scholarly journals Validity of a minimally invasive autopsy tool for cause of death determination in pediatric deaths in Mozambique: An observational study

PLoS Medicine ◽  
2017 ◽  
Vol 14 (6) ◽  
pp. e1002317 ◽  
Author(s):  
Quique Bassat ◽  
Paola Castillo ◽  
Miguel J. Martínez ◽  
Dercio Jordao ◽  
Lucilia Lovane ◽  
...  
Keyword(s):  
Observational Study ◽  
Minimally Invasive ◽  
Cause Of Death ◽  
Minimally Invasive Autopsy ◽  
Death Determination

scholarly journals Validity of a minimally invasive autopsy for cause of death determination in stillborn babies and neonates in Mozambique: An observational study

PLoS Medicine ◽  
2017 ◽  
Vol 14 (6) ◽  
pp. e1002318 ◽  
Author(s):  
Clara Menendez ◽  
Paola Castillo ◽  
Miguel J. Martínez ◽  
Dercio Jordao ◽  
Lucilia Lovane ◽  
...  
Keyword(s):  
Observational Study ◽  
Minimally Invasive ◽  
Cause Of Death ◽  
Minimally Invasive Autopsy ◽  
Death Determination
Sign in / Sign up

Export Citation Format

Share Document