Exogenous Nitric Oxide Stimulates Cell Proliferation via Activation of a Mitogen-Activated Protein Kinase Pathway in Ovine Fetoplacental Artery Endothelial Cells1

Biology of Reproduction ◽

10.1095/biolreprod.105.043190 ◽

2006 ◽

Vol 74 (2) ◽

pp. 375-382 ◽

Author(s):

Jing Zheng ◽

YunXia Wen ◽

Jason L. Austin ◽

Dong-bao Chen

Keyword(s):

Nitric Oxide ◽

Cell Proliferation ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Exogenous Nitric Oxide ◽

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Lactotransferrin: A candidate tumor suppressor-Deficient expression in human nasopharyngeal carcinoma and inhibition of NPC cell proliferation by modulating the mitogen-activated protein kinase pathway

International Journal of Cancer ◽

10.1002/ijc.23727 ◽

2008 ◽

Vol 123 (9) ◽

pp. 2065-2072 ◽

Author(s):

Yanhong Zhou ◽

Zhaoyang Zeng ◽

Wenling Zhang ◽

Wei Xiong ◽

Minghua Wu ◽

...

Keyword(s):

Cell Proliferation ◽

Protein Kinase ◽

Nasopharyngeal Carcinoma ◽

Tumor Suppressor ◽

Mitogen Activated Protein Kinase ◽

Candidate Tumor Suppressor ◽

Human Nasopharyngeal Carcinoma ◽

Mitogen Activated Protein ◽

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A nitric oxide/Ca2+ /calmodulin/ERK1/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1β in human astrocytoma cells

British Journal of Pharmacology ◽

10.1038/bjp.2008.40 ◽

2008 ◽

Vol 153 (8) ◽

pp. 1706-1717 ◽

Author(s):

A Meini ◽

C Sticozzi ◽

L Massai ◽

M Palmi

Keyword(s):

Nitric Oxide ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Mitogenic Effect ◽

Astrocytoma Cells ◽

Human Astrocytoma ◽

Mitogen Activated Protein ◽

Kinase Pathway ◽

Human Astrocytoma Cells

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Activation of Mitogen-Activated Protein Kinase Pathway by Keratinocyte Growth Factor or Fibroblast Growth Factor-10 Promotes Cell Proliferation in Human Endometrial Carcinoma Cells

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2002-021062 ◽

2003 ◽

Vol 88 (2) ◽

pp. 773-780 ◽

Author(s):

Fuminori Taniguchi ◽

Tasuku Harada ◽

Yasuko Sakamoto ◽

Nobuhiro Yamauchi ◽

Souichi Yoshida ◽

...

Keyword(s):

Cell Proliferation ◽

Growth Factor ◽

Protein Kinase ◽

Keratinocyte Growth Factor ◽

Carcinoma Cells ◽

Mitogen Activated Protein Kinase ◽

Fibroblast Growth ◽

Mitogen Activated Protein ◽

Fibroblast Growth Factor 10 ◽

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Glycated Serum Albumin-Induced Vascular Smooth Muscle Cell Proliferation through Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Protein Kinase C

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.2001.4655 ◽

2001 ◽

Vol 282 (3) ◽

pp. 850-851

Author(s):

Yoshiyuki Hattori ◽

Hirobumi Kakishita ◽

Kazumi Akimoto ◽

Mihoko Matsumura ◽

Kikuo Kasai

Keyword(s):

Cell Proliferation ◽

Smooth Muscle ◽

Protein Kinase C ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Kinase C ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

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CARDIAC NITRIC OXIDE SYNTHASE ACTIVATION VIA C-TYPE NATRIURETIC PEPTIDE: ROLE OF MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY IN HYPERTENSION: PP.22.390

Journal of Hypertension ◽

10.1097/01.hjh.0000379316.21399.80 ◽

2010 ◽

Vol 28 ◽

pp. e362-e363

Author(s):

M Costa ◽

C Caniffi ◽

M Romero ◽

L Savignano ◽

S Rodríguez ◽

...

Keyword(s):

Nitric Oxide ◽

Protein Kinase ◽

Nitric Oxide Synthase ◽

Natriuretic Peptide ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Oxide Synthase ◽

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Exogenous nitric oxide negatively regulates the S-nitrosylation p38 mitogen-activated protein kinase activation during cerebral ischaemia and reperfusion

Neuropathology and Applied Neurobiology ◽

10.1111/j.1365-2990.2012.01284.x ◽

2013 ◽

Vol 39 (3) ◽

pp. 284-297 ◽

Author(s):

S. H. Qi ◽

L. Y. Hao ◽

J. Yue ◽

Y. Y. Zong ◽

G. Y. Zhang

Keyword(s):

Nitric Oxide ◽

Protein Kinase ◽

Cerebral Ischaemia ◽

Mitogen Activated Protein Kinase ◽

Kinase Activation ◽

Protein Kinase Activation ◽

Ischaemia And Reperfusion ◽

Mitogen Activated Protein ◽

Exogenous Nitric Oxide

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5-Hydroxytryptophan Acts on the Mitogen-Activated Protein Kinase Extracellular-Signal Regulated Protein Kinase Pathway to Modulate Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in RAW 264.7 Cells

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.32.553 ◽

2009 ◽

Vol 32 (4) ◽

pp. 553-557 ◽

Author(s):

Hee-Sung Chae ◽

Ok-Hwa Kang ◽

Jang-Gi Choi ◽

You-Chang Oh ◽

Young-Seob Lee ◽

...

Keyword(s):

Nitric Oxide ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Oxide Synthase ◽

Kinase Pathway ◽

Inducible Nitric Oxide

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Blockade of the p38 Mitogen-activated Protein Kinase Pathway Inhibits Inducible Nitric Oxide Synthase and Interleukin-6 Expression in MC3T3E-1 Osteoblasts

Pharmacological Research ◽

10.1006/phrs.2000.0778 ◽

2001 ◽

Vol 43 (3) ◽

pp. 275-282 ◽

Author(s):

Han-Jung Chae ◽

Sang-Chul Kim ◽

Soo-Wan Chae ◽

Nyeon-hyoung an ◽

Hong-Hee Kim ◽

...

Keyword(s):

Nitric Oxide ◽

Protein Kinase ◽

Nitric Oxide Synthase ◽

Inducible Nitric Oxide Synthase ◽

Interleukin 6 ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Oxide Synthase ◽

Kinase Pathway ◽

Inducible Nitric Oxide

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Carbon Monoxide Inhibits Human Airway Smooth Muscle Cell Proliferation via Mitogen-Activated Protein Kinase Pathway

American Journal of Respiratory Cell and Molecular Biology ◽

10.1165/rcmb.4851 ◽

2002 ◽

Vol 27 (5) ◽

pp. 603-610 ◽

Author(s):

Ruiping Song ◽

Raja S. Mahidhara ◽

Fang Liu ◽

Wen Ning ◽

Leo E. Otterbein ◽

...

Keyword(s):

Cell Proliferation ◽

Carbon Monoxide ◽

Smooth Muscle ◽

Protein Kinase ◽

Smooth Muscle Cell ◽

Airway Smooth Muscle Cell ◽

Mitogen Activated Protein Kinase ◽

Human Airway Smooth Muscle ◽

Mitogen Activated Protein ◽

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Endothelin-1 Is a Potent Survival Factor for c-Myc-Dependent Apoptosis

Molecular Endocrinology ◽

10.1210/mend.12.2.0064 ◽

1998 ◽

Vol 12 (2) ◽

pp. 172-180 ◽

Author(s):

Masayoshi Shichiri ◽

John M. Sedivy ◽

Fumiaki Marumo ◽

Yukio Hirata

Keyword(s):

Cell Proliferation ◽

Protein Kinase ◽

Survival Function ◽

Fibroblast Cell ◽

Mitogen Activated Protein Kinase ◽

Endothelin 1 ◽

Survival Factor ◽

Mitogen Activated Protein ◽

Eta Receptor ◽

Abstract Many vertebrate cells are resistant to apoptotic stimuli, whose variety and the mechanisms involved are not fully understood. Endothelin-1 is an endothelium-derived vasoactive peptide that mediates many physiological functions, such as vasoconstriction and cell proliferation. Deregulated expression of c-Myc induces apoptosis in serum-deprived fibroblasts. Using a panel of isogenic fibroblast cell lines with differential c-myc expression levels, we demonstrate that low doses of endothelin-1 protect fibroblasts against serum deprivation-induced apoptosis, which occurs through a c-Myc-dependent process. The endothelin-1-induced cell survival was mediated by the ETA receptor and was not linked to the ability of endothelin-1 to induce cell proliferation. The survival function of endothelin-1 was abrogated by inhibiting the mitogen-activated protein kinase pathway. These results demonstrate a hitherto unappreciated role of endothelin-1 as a potent survival factor for c-Myc-dependent apoptosis, a process mediated by the ETA receptor and the mitogen-activated protein kinase pathway.

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