scholarly journals The association of Vitamin D levels to advanced liver fibrosis and response to hepatitis C therapy

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
mashair Khougali Abdelrahman Elhag ◽  
shihab Deiab ◽  
Nadia Hussain ◽  
Rasha Khougali Abdelrahman Aziz
Keyword(s):  
Vitamin D ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Hepatitis C Therapy ◽  
Vitamin D Levels ◽  
Advanced Liver Fibrosis

Relationship of vitamin D status with advanced liver fibrosis and response to hepatitis C virus therapy: A meta-analysis

Hepatology ◽  
2014 ◽  
Vol 60 (5) ◽  
pp. 1541-1550 ◽  
Author(s):  
Mónica García-Álvarez ◽  
Daniel Pineda-Tenor ◽  
María A. Jiménez-Sousa ◽  
Amanda Fernández-Rodríguez ◽  
María Guzmán-Fulgencio ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Meta Analysis ◽  
Vitamin D Status ◽  
Advanced Liver Fibrosis ◽  
Relationship Of

scholarly journals Is there an association between vitamin D and liver fibrosis in patients with chronic hepatitis C?

2017 ◽  
Vol 54 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Kalinca da Silva OLIVEIRA ◽  
Caroline BUSS ◽  
Cristiane Valle TOVO
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Serum Vitamin ◽  
Inflammatory Activity ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Study Results

ABSTRACT BACKGROUND Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. OBJECTIVE This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection. METHODS Cross-sectional study composed of patients with chronic hepatitis C. All patients underwent vitamin D 25 dosage and anthropometric data analysis. Liver biopsy was performed in a maximum 36-month period before inclusion in the study. RESULTS Of the 74 patients included in the study, 45 (60.8%) were women, mean age was 57.03±9.24 years, and 63 (85.1%) were white. No association was observed between the serum levels of vitamin D and inflammatory activity (P=0.699) nor with the degree of liver fibrosis (P=0.269). CONCLUSION In this study, no association was observed between vitamin D and inflammatory activity, as well as the degree of liver fibrosis, in patients with chronic hepatitis C.

108 ASSOCIATION OF GENES REGULATING VITAMIN D HOMEOSTASIS WITH VITAMIN D LEVELS AND LIVER FIBROSIS IN A COHORT OF PATIENTS WITH CHRONIC LIVER DISEASE

2011 ◽  
Vol 54 ◽  
pp. S48-S49
Author(s):  
F. Grünhage ◽  
K. Hochrath ◽  
M. Krawczyk ◽  
B. Obermayer-Pietsch ◽  
M. Trauner ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Liver Fibrosis ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Vitamin D Levels

Dynamic Evaluation of Liver Fibrosis to Assess the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis C Who Achieved Sustained Virologic Response

2019 ◽  
Author(s):  
Hidenori Toyoda ◽  
Toshifumi Tada ◽  
Satoshi Yasuda ◽  
Kazuyuki Mizuno ◽  
Takanori Ito ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Sustained Virologic Response ◽  
Dynamic Assessment ◽  
Predictive Ability ◽  
Virologic Response ◽  
Hcv Therapy ◽  
Number Of Patients ◽  
Advanced Liver Fibrosis

Abstract Background Liver fibrosis is an important risk factor for the development of hepatocellular carcinoma (HCC) after sustained virologic response (SVR) in patients with persistent hepatitis C virus (HCV) infection. However, as the degree of liver fibrosis changes following the eradication of HCV after SVR, it is unclear whether the prediction of HCC development based on liver fibrosis at baseline remains valid. Methods In 522 patients who achieved SVR by interferon-based anti-HCV therapy, the Fibrosis-4 Index for Liver Fibrosis (FIB-4 index) was updated annually by recalculation based on laboratory values after SVR. The incidence of HCC was reassessed annually based on the updated FIB-4 index. Results The percentage of patients with mild liver fibrosis (FIB-4 index <1.45) increased annually after SVR, whereas the percentage of patients with advanced liver fibrosis (FIB-4 index ≥3.25) decreased. The incidences of HCC based on the FIB-4 index remained constant between the time of SVR and subsequent annual updates. No patients developed HCC after SVR if the FIB-4 index decreased to <1.45. Conclusions The FIB-4 index retained its predictive ability for the risk of HCC when recalculated after SVR, despite the decrease in patients with high FIB-4 index values. Dynamic assessment of the FIB-4 index can be useful in the surveillance of HCC after SVR. Patients with a FIB-4 index <1.45 did not develop HCC even by the regression from advanced fibrosis after SVR. Further studies will be necessary to confirm these findings, which may result in a decrease in the number of patients in whom surveillance is required.

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