scholarly journals Regulation of RNA Polymerase III Transcription Factors BRF1 and BRF2 by Cancer Stem Cell Signaling Pathways

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Stephanie M. Cabarcas‐Petroski ◽  
Laura Schramm
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Cancer Stem Cell ◽  
Rna Polymerase ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Rna Polymerase Iii ◽  
Polymerase Iii ◽  
Cell Signaling Pathways

scholarly journals Novel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathways

2015 ◽  
Vol 11 (6) ◽  
pp. 909-918 ◽  
Author(s):  
Danysh Abetov ◽  
Zhanar Mustapova ◽  
Timur Saliev ◽  
Denis Bulanin ◽  
Kanat Batyrbekov ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Cell Signaling Pathways

scholarly journals A Synthetic Triterpenoid CDDO-Im Inhibits Tumorsphere Formation by Regulating Stem Cell Signaling Pathways in Triple-Negative Breast Cancer

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107616 ◽  
Author(s):  
Jae Young So ◽  
Janice J. Lin ◽  
Joseph Wahler ◽  
Karen T. Liby ◽  
Michael B. Sporn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cell Signaling Pathways

scholarly journals Turning Cancer Stem Cells Inside Out: An Exploration of Glioma Stem Cell Signaling Pathways

2009 ◽  
Vol 284 (25) ◽  
pp. 16705-16709 ◽  
Author(s):  
Zhizhong Li ◽  
Hui Wang ◽  
Christine E. Eyler ◽  
Anita B. Hjelmeland ◽  
Jeremy N. Rich
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Glioma Stem Cell ◽  
Inside Out ◽  
Cell Signaling Pathways

scholarly journals TFIIIC1 acts through a downstream region to stabilize TFIIIC2 binding to RNA polymerase III promoters.

1996 ◽  
Vol 16 (12) ◽  
pp. 6841-6850 ◽  
Author(s):  
Z Wang ◽  
R G Roeder
Keyword(s):  
Transcription Factors ◽  
Rna Polymerase ◽  
Weak Interaction ◽  
Strong Interaction ◽  
Rna Polymerase Iii ◽  
Cooperative Interaction ◽  
In Vitro System ◽  
Polymerase Iii ◽  
Footprint Analysis

An in vitro system reconstituted with highly purified RNA polymerase III, TFIIIC2, and TFIIIB has been used to identify two chromatographically distinct human RNA polymerase III transcription factors, TFIIIC1 and TFIIIC1', which are functionally equivalent to the previously defined TFIIIC1 (S. T. Yoshinaga, P. A. Boulanger, and A. J. Berk, Proc. Natl. Acad. Sci. USA 84:3585-3589, 1987). Interactions between TFIIIC2, TFIIIC1 (or TFIIIC1'), and the VA1 and tRNA1(Met) templates have been investigated by DNase I footprint analysis. Homogeneous TFIIIC2 alone shows only a weak footprint over the B-box region of the VA1 and tRNA1(Met) templates, whereas TFIIIC1 (or TFIIIC1') alone shows both a strong interaction over the downstream termination region and a very weak interaction near the A-box region. Importantly, when both factors are present simultaneously, TFIIIC1 (or TFIIIC1') dramatically enhances the level of TFIIIC2 binding and extends the footprint to a region that includes the A box. The downstream termination region is essential for this cooperative interaction between TFIIIC2 and TFIIIC1 (or TFIIIC1') on the VA1 and tRNA1(Met) templates and plays a role in the overall accuracy and efficiency of RNA polymerase III transcription.

scholarly journals Curcumin and Cancer

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2376 ◽  
Author(s):  
Giordano ◽  
Tommonaro
Keyword(s):  
Transcription Factors ◽  
Growth Factors ◽  
Cancer Therapy ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Inflammatory Cytokines ◽  
Biological Activities ◽  
Curcuma Longa ◽  
Cancer Development ◽  
Cell Signaling Pathways

Curcumin, a polyphenol extracted from Curcuma longa in 1815, has gained attention from scientists worldwide for its biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral), among which its anticancer potential has been the most described and still remains under investigation. The present review focuses on the cell signaling pathways involved in cancer development and proliferation, and which are targeted by curcumin. Curcumin has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines, and proapoptotic (by upregulation) and antiapoptotic (by downregulation) proteins. This polyphenol compound, alone or combined with other agents, could represent an effective drug for cancer therapy.

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