Protein Kinase‐C Inhibition Within the Periaqueductal Gray Counteracts the Development of Morphine Antinociceptive Tolerance

The FASEB Journal ◽

10.1096/fasebj.2021.35.s1.03935 ◽

2021 ◽

Vol 35 (S1) ◽

Author(s):

Akila Ram ◽

Max McDermott ◽

Leela Afrose ◽

Taylor Edwards ◽

Ashley McCarty ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Periaqueductal Gray ◽

Kinase C ◽

Antinociceptive Tolerance

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Antagonizing effect of protein kinase C activation on the μ-opioid agonist-induced inhibition of high voltage-activated calcium current in rat periaqueductal gray neuron

Brain Research ◽

10.1016/s0006-8993(01)02864-5 ◽

2001 ◽

Vol 916 (1-2) ◽

pp. 61-69 ◽

Author(s):

Young-Wuk Cho ◽

Seung-Ho Han ◽

Byung-Il Min ◽

Jeong-Seop Rhee ◽

Norio Akaike

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

High Voltage ◽

Calcium Current ◽

Periaqueductal Gray ◽

Opioid Agonist ◽

Kinase C ◽

Protein Kinase C Activation

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Involvement of protein kinase c in responses of rat dorsal horn neurons to mechanical stimuli and periaqueductal gray descending inhibition

Experimental Brain Research ◽

10.1007/pl00005664 ◽

1997 ◽

Vol 114 (3) ◽

pp. 561-570 ◽

Author(s):

Yuan B. Peng ◽

Qing Lin ◽

W. D. Willis

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Dorsal Horn ◽

Periaqueductal Gray ◽

Mechanical Stimuli ◽

Descending Inhibition ◽

Dorsal Horn Neurons ◽

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Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered μ-opioid receptor agonist in the mouse

European Journal of Pharmacology ◽

10.1016/0014-2999(95)00322-c ◽

1995 ◽

Vol 280 (2) ◽

pp. R1-R3 ◽

Author(s):

Minoru Narita ◽

Michiko Narita ◽

Hirokazu Mizoguchi ◽

Leon F. Tseng

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Protein Kinase A ◽

Opioid Receptor ◽

Receptor Agonist ◽

Kinase C ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor ◽

Antinociceptive Tolerance ◽

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Nocistatin excites rostral agranular insular cortex-periaqueductal gray projection neurons by enhancing transient receptor potential cation conductance via Gαq/11-PLC-protein kinase C pathway

Neuroscience ◽

10.1016/j.neuroscience.2010.03.054 ◽

2010 ◽

Vol 168 (1) ◽

pp. 226-239 ◽

Author(s):

Y.L. Chen ◽

A.H. Li ◽

T.H. Yeh ◽

A.H. Chou ◽

Y.S. Weng ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Transient Receptor Potential ◽

Insular Cortex ◽

Receptor Potential ◽

Periaqueductal Gray ◽

Projection Neurons ◽

Kinase C ◽

Cation Conductance ◽

Transient Receptor

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Antisense oligonucleotide knockdown of mGlu5 receptor attenuates the antinociceptive tolerance and up-regulated expression of spinal protein kinase C associated with chronic morphine treatment

European Journal of Pharmacology ◽

10.1016/j.ejphar.2012.02.046 ◽

2012 ◽

Vol 683 (1-3) ◽

pp. 78-85 ◽

Author(s):

Tao Xu ◽

Moxi Chen ◽

Quanhong Zhou ◽

Ying Xue ◽

Li Wang ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Antisense Oligonucleotide ◽

Morphine Treatment ◽

Chronic Morphine ◽

Kinase C ◽

Mglu5 Receptor ◽

Regulated Expression ◽

Chronic Morphine Treatment ◽

Antinociceptive Tolerance

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Role of protein kinase C in opioid modulation of glycine-gated Cl− current in rat periaqueductal gray neuron

European Journal of Pharmacology ◽

10.1016/s0014-2999(01)01397-8 ◽

2001 ◽

Vol 431 (2) ◽

pp. 143-150 ◽

Author(s):

Hyo-Jin Jeong ◽

Jong-Ju Lee ◽

Eu-Teum Hahm ◽

Seung-Ho Han ◽

Byung-Il Min ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Periaqueductal Gray ◽

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Modulation of tight junction (TJ) structure by enteroinvasive E. coli (EIEC) is prevented by H2O2 scavengers and protein kinase C(PKC) inhibitors

Gastroenterology ◽

10.1016/s0016-5085(01)83509-5 ◽

2001 ◽

Vol 120 (5) ◽

pp. A705-A705

Author(s):

S RESTALENERT ◽

K BARRETT

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Tight Junction ◽

E Coli ◽

Kinase C ◽

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Protein kinase C (PKC)-β1 mediates EGF-induced protection of the microtubule (MT) cytoskeleton & intestinal barrier function (BF) against oxidant injury

Gastroenterology ◽

10.1016/s0016-5085(01)83491-0 ◽

2001 ◽

Vol 120 (5) ◽

pp. A701-A701

Author(s):

A BANAN ◽

J FIELDS ◽

Y ZHANG ◽

E MUTLU ◽

A KESHAVARZIAN

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Barrier Function ◽

Intestinal Barrier ◽

Intestinal Barrier Function ◽

Oxidant Injury ◽

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Secretagogue (caerulein)-induced intrapancreatic activation of trypsinogen is mediated by protein kinase C (PKC), phosphoinositide-3-kinases (PI-3Ks) and tyrosine kinases (TKs)

Gastroenterology ◽

10.1016/s0016-5085(01)81674-7 ◽

2001 ◽

Vol 120 (5) ◽

pp. A337-A337

Author(s):

V SINGH ◽

A SALUJA ◽

L BHAGAT ◽

G VANACKER ◽

A SONG ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Tyrosine Kinases ◽

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Cytokine production in human intestinal mast cells triggered by Fc∈ receptor cross-linking is dependent on both protein kinase C and MAP kinase

Gastroenterology ◽

10.1016/s0016-5085(01)82469-0 ◽

2001 ◽

Vol 120 (5) ◽

pp. A497-A497

Author(s):

A LORENTZ ◽

I KLOPP ◽

T GEBHARDT ◽

M MANNS ◽

S BISCHOFF

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Cytokine Production ◽

Fc Receptor ◽

Cross Linking ◽

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