scholarly journals Hyperbaric Oxygen Therapy Reversed Cognitive Deficits in a Murine Model of Alzheimer's Disease

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Paapa Mensah Kane ◽  
Delaney Davis ◽  
Philip Vann ◽  
Lad Dory ◽  
Nathalie Sumien
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hyperbaric Oxygen ◽  
Cognitive Deficits ◽  
Murine Model ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Model Of Alzheimer’S Disease

scholarly journals CNF1 Increases Brain Energy Level, Counteracts Neuroinflammatory Markers and Rescues Cognitive Deficits in a Murine Model of Alzheimer's Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e65898 ◽  
Author(s):  
Stefano Loizzo ◽  
Roberto Rimondini ◽  
Sara Travaglione ◽  
Alessia Fabbri ◽  
Marco Guidotti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Energy Level ◽  
Cognitive Deficits ◽  
Murine Model ◽  
Model Of Alzheimer’S Disease ◽  
Brain Energy

scholarly journals Integrative Role of Hyperbaric Oxygen Therapy on Healthspan, Age-Related Vascular Cognitive Impairment, and Dementia

2021 ◽  
Vol 2 ◽  
Author(s):  
Priya Balasubramanian ◽  
Jordan Delfavero ◽  
Adam Nyul-Toth ◽  
Amber Tarantini ◽  
Rafal Gulej ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Vascular Cognitive Impairment ◽  
The Body ◽  
World Population ◽  
Age Related

Growing life expectancy will contribute to the on-going shift towards a world population increasingly comprised of elderly individuals. This demographic shift is associated with a rising prevalence of age-related diseases, among all age-related pathologies it has become crucial to understand the age-associated cognitive changes that remain a major risk factor for the development of vascular cognitive impairment and dementia (VCID). Furthermore, age-related Alzheimer’s disease and other neurogenerative diseases with vascular etiology are the most prominent contributing factors for the loss of cognitive function observed in aging. Hyperbaric Oxygen Therapy (HBOT) achieves physiologic effects by increasing oxygen tension (PO2), raising oxygen tissue levels, decreasing intracranial pressure and relieving cerebral edema. Many of the beneficial effects of HBOT exert their protective effects at the level of the microcirculation. Furthermore, the microcirculation’s exquisite pervasive presence across every tissue in the body, renders it uniquely able to influence the local environment of most tissues and organs, including the brain. As such, treatments aimed at restoring aging-induced functional and structural alterations of the cerebral microcirculation may potentially contribute to the amelioration of a range of age-related pathologies including vascular cognitive impairment, Alzheimer’s disease, and vascular dementias. Despite the presented evidence, the efficacy and safety of HBOT for the treatment of age-related vascular cognitive impairment and dementia remains understudied. The present review aims to examine the existing evidence indicative of a potential therapeutic role for HBOT-induced hyperoxia against age-related cerebromicrovascular pathologies contributing to cognitive impairment, dementia and decreased healthspan in the elderly.

A Review of the Application of Hyperbaric Oxygen Therapy in Alzheimer’s Disease

2021 ◽  
pp. 1-7
Author(s):  
Fahad Somaa
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Experimental Studies ◽  
Treatment Protocol ◽  
Online Data ◽  
Online Data Base

Alzheimer’s disease (AD) is considered as the most common cause of dementia in elderly population. While the exact mechanism of AD has not been discovered, hyperbolic oxygen therapy (HBOT) has been proven to be effective in the treatment of this degenerative disease. The objectives of this article are to review the literature available on molecular and physiological mechanisms underlying HBOT and its efficacy in treating AD and to review the effectiveness of HBOT as an alternate treatment intervention in both human and animal models. 391 full text articles were included in the review after literature search between 1980–2021 from two online data base (ScienceDirect and PubMed). The following key words were used: ‘hyperbaric oxygen therapy’ and ‘Alzheimer disease.’ Based on the outcomes of clinical and experimental studies, this review advocates the use of HBOT for the treatment of AD. This review explores future directions and recommends further research into a treatment protocol that will maintain long-term cognitive health of AD patients.

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