scholarly journals Oxidative protein damage is associated with poor grip strength among older women living in the community

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Caitlin Therese Howard ◽  
Luigi Ferrucci ◽  
Kai Sun ◽  
Linda P Fried ◽  
Jeremy Walston ◽  
...  
Keyword(s):  
Grip Strength ◽  
Older Women ◽  
Protein Damage ◽  
Oxidative Protein Damage

scholarly journals Oxidative protein damage is associated with poor grip strength among older women living in the community

2007 ◽  
Vol 103 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Caitlin Howard ◽  
Luigi Ferrucci ◽  
Kai Sun ◽  
Linda P. Fried ◽  
Jeremy Walston ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Muscle Strength ◽  
Grip Strength ◽  
Older Women ◽  
Protein Carbonyl ◽  
Protein Damage ◽  
Protein Carbonyls ◽  
Cross Sectional ◽  
Oxidative Protein Damage

Grip strength, an indicator of muscle strength, has been shown to be a predictor of poor outcomes among older adults. Protein carbonylation, an indicator of oxidative damage to proteins, leads to cellular dysfunction and a decline in tissue function. Oxidative stress has been implicated in the pathogenesis of sarcopenia. The objective was to determine whether serum protein carbonyl concentrations are associated with grip strength in older women living in the community. A cross-sectional study was conducted in 672 women, aged 65 and older, from the Women's Health and Aging Study (WHAS) I, the one-third most disabled women residing in the community in Baltimore, MD. Protein carbonyl and grip strength were measured in each patient. In a multivariate analysis adjusting for age, race, body mass index, and Mini-Mental Status Examination score, protein carbonyls (nmol/mg) were associated with grip strength (β = −6.77, P < 0.01). The statistical association was unchanged after the analysis adjusted for hypertension, congestive heart failure, and depression. Ordered logistic regression models adjusted for the above factors showed that protein carbonyls are associated with increased odds of being in the lower quartiles of grip strength (odds ratio 8.74, 95% confidence interval 1.06–71.89, P = 0.043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults.

scholarly journals Relationship of antioxidant nutrients with oxidative protein damage among older women living in the community

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Narges Alipanah ◽  
Luigi Ferrucci ◽  
Kai Sun ◽  
Linda P Fried ◽  
Jeremy Walston ◽  
...  
Keyword(s):  
Older Women ◽  
Protein Damage ◽  
Oxidative Protein Damage ◽  
Relationship Of

scholarly journals Protein damage, ageing and age-related diseases

Open Biology ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 180249 ◽  
Author(s):  
Anita Krisko ◽  
Miroslav Radman
Keyword(s):  
Oxidative Damage ◽  
Protein Damage ◽  
Death Studies ◽  
Root Cause ◽  
Age Related ◽  
Oxidative Protein Damage ◽  
Gompertz Law ◽  
Radiation Induced ◽  
Folded Proteins

Ageing is considered as a snowballing phenotype of the accumulation of damaged dysfunctional or toxic proteins and silent mutations (polymorphisms) that sensitize relevant proteins to oxidative damage as inborn predispositions to age-related diseases. Ageing is not a disease, but it causes (or shares common cause with) age-related diseases as suggested by similar slopes of age-related increase in the incidence of diseases and death. Studies of robust and more standard species revealed that dysfunctional oxidatively damaged proteins are the root cause of radiation-induced morbidity and mortality. Oxidized proteins accumulate with age and cause reversible ageing-like phenotypes with some irreversible consequences (e.g. mutations). Here, we observe in yeast that aggregation rate of damaged proteins follows the Gompertz law of mortality and review arguments for a causal relationship between oxidative protein damage, ageing and disease. Aerobes evolved proteomes remarkably resistant to oxidative damage, but imperfectly folded proteins become sensitive to oxidation. We show that α-synuclein mutations that predispose to early-onset Parkinson's disease bestow an increased intrinsic sensitivity of α-synuclein to in vitro oxidation. Considering how initially silent protein polymorphism becomes phenotypic while causing age-related diseases and how protein damage leads to genome alterations inspires a vision of predictive diagnostic, prognostic, prevention and treatment of degenerative diseases.

Effects of 24 weeks strength training with and without unstable devices on strength, flexibility and quality of life in older women: A secondary analysis from randomized controlled trial

2020 ◽  
pp. 1-9
Author(s):  
André Luiz Torres Pirauá ◽  
Valéria Mayaly Alves de Oliveira ◽  
Bruno Remígio Cavalcante ◽  
Natália Barros Beltrão ◽  
Gabriel de Amorim Batista ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Strength Training ◽  
Grip Strength ◽  
Older Women ◽  
Moderate Intensity ◽  
Health Related Quality ◽  
Strength Exercises ◽  
Related Quality ◽  
Health Related

BACKGROUND: Combining strength training (ST) with unstable surfaces (US) is a promising complementary approach to traditional ST to optimize muscle strength and balance in different populations. OBJECTIVE: To evaluate the effects of traditional ST and ST+US on grip strength, flexibility and quality of life in older women. METHODS: Fifty-eight older women were randomly assigned into ST (n= 22), ST+US (n= 22) or control (n= 14) group. Exercise groups performed whole-body, moderate-intensity strength exercises, thrice a week during 24-weeks. ST+US participants performed the same exercise prescription progressively adding unstable surfaces and devices. Dependent variables (grip strength, flexibility and health-related quality of life) were measured at baseline, 12-weeks and after 24-weeks of intervention. RESULTS: At completion of 24-weeks, compared with control group, traditional ST promote flexibility gains [SRT =+ 5.42 cm (95% CI = 1.01 to 9.83)]. Both training regimes improved quality of life [ST =+9.50 (95% CI = 1.80 to 17.20); ST+US =+ 15.23 (95%CI = 7.37 to 23.08). No significant between-group difference was observed for grip strength at completion of the intervention. CONCLUSION: Traditional strength exercises were effective to improve flexibility and health-related quality of life among healthy older women. Combining unstable devices with traditional exercise did not provide additional gains in order to promote flexibility and quality of life.

scholarly journals Combined Chair-Based Exercises Improve Functional Fitness, Mental Well-Being, Salivary Steroid Balance, and Anti-microbial Activity in Pre-frail Older Women

2021 ◽  
Vol 12 ◽  
Author(s):  
Guilherme Eustáquio Furtado ◽  
Rubens Vinícius Letieri ◽  
Adriana Silva-Caldo ◽  
Joice C. S. Trombeta ◽  
Clara Monteiro ◽  
...  
Keyword(s):  
Mental Health ◽  
Grip Strength ◽  
Older Women ◽  
Steroid Hormones ◽  
Gait Speed ◽  
Well Being ◽  
Hand Grip Strength ◽  
Functional Fitness ◽  
Hand Grip ◽  
Mental Well Being

IntroductionRegular exercise has long been shown to positively impact the immune system responsiveness and improve mental well-being (MWB). However, the putative links between biomarkers of mental health and immune efficiency in exercising subjects have been scarcely investigated. The aim of this study was to verify the effect of a 14-week combined chair-based exercise program (CEP) on salivary steroid hormones and anti-microbial proteins, functional fitness, and MWB indexes in pre-frail older women.MethodsThe participant women (82.8 4.6 years old; n = 32) were randomly divided into the exercising group (CEP, n = 17) and the non-exercising control group (CG, n = 15). The pre/post assessment included: (1) salivary anti-microbial proteins lysozyme; (Lys) and immunoglobulin-A (IgA); (2) salivary steroid hormones of testosterone (TT) and cortisol (COR); (3) functional fitness (gait speed, hand grip strength, and static balance); (4) MWB questionnaires (happiness, depression state, satisfaction with life, and stress).ResultsSignificant differences with large Cohen’s (d) effect sizes were found on increased salivary TT (p &lt; 0.05; d = 0.60) after exercise intervention. The results revealed a decrease in IgA levels after CEP (p &lt; 0.01, d = 0.30). The increase in subjective happiness levels (p &lt; 0.05, d = 0.30) and decrease of stress perception (p &lt; 0.01, d = 2.60) and depressive state (p &lt; 0.05, d = 0.30) were found after intervention in the CEP group. Robust statistical differences in gait speed (p &lt; 0.05; d = 0.60) and balance tests (p &lt; 0.05; d = 0.80) were also found in the CEP group. In control, COR increased moderately (p &lt; 0.05; d = 0.65) while no changes were found for the other indicators. Correlation analyses showed inter-dependence between pre–post variations of MWB, biochemical indexes, and fitness function (e.g., COR inverse correlation with hand grip strength and balance tests).ConclusionThe CEP program was able to improve functional-fitness performance, decrease feelings of stress, and increase happiness. The CEP also induced clinically relevant hormonal and immune responses, which suggests that chair exercises that combine muscular strength, balance, and gait speed training are promising interventions to improve physical and mental health of older pre-frail adults.

scholarly journals Components of physical fitness as prognostic factors for falls in elderly female exercise practitioners: a longitudinal study

2020 ◽  
Vol 33 ◽  
Author(s):  
Giovana Zarpellon Mazo ◽  
Raquel Ester Lima ◽  
Pedro Silvelo Franco ◽  
Leonardo Hoffmann ◽  
Enaiane Cristina Menezes
Keyword(s):  
Physical Fitness ◽  
Grip Strength ◽  
Older Women ◽  
Lower Limb ◽  
Hand Grip Strength ◽  
Left Hand ◽  
Elderly Female ◽  
Hand Grip ◽  
Risk Of Falls ◽  
Falls In Elderly

Abstract Introduction: Physical exercise is used as a strategy for the prevention of falls because it improves the physical fitness of older adults. Objective: To determine which components of physical fitness are predictors of falls in elderly female exercise practitioners. Method: Longitudinal, descriptive, comparative study. The components of physical fitness (upper and lower limb strength and flexibility, agility, aerobic endurance, and hand grip strength) and the occurrence or not of falls in the last 12 months were analyzed in 80 older women practitioners of exercise from 2013 to 2016. Descriptive analysis, ROC curve attributing cut-off points, and binary logistic regression for the prediction of falls were used. Results: The mean age of the participants was 67.46 years (SD=7.65). Over the years, a significant difference between elderly fallers and non-fallers was observed for right hand grip strength (2013 and 2015), left hand grip strength (2014 and 2015), lower limb flexibility (2013, 2014 and 2015), agility (2015), and aerobic endurance (2015). In adjusted analysis, older women with poor lower limb flexibility in 2013 had a higher risk of falls in 2016 (OR=4.98; 95%CI 1.12 - 22.1). Older women with poor flexibility in 2015 also had a higher risk of falls (OR= 6.08; 95%CI 1.06 - 34.67). Conclusion: Poor performance in the lower limb flexibility, right and left hand grip strength, agility and aerobic endurance tests was associated with falls and these components are predictors of future falls in elderly exercise practitioners.

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