scholarly journals Rosiglitazone Decreases Blood Pressure in Female Dahl Rats: Role of Nitric Oxide and Oxidative Stress

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Julio C. Sartori‐Valinotti ◽  
Michael J. Ryan ◽  
Huimin Zhang ◽  
Jane F. Reckelhoff
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Blood Pressure ◽  
And Oxidative Stress

Coronary flow and oxidative stress during local anaphylactic reaction in isolated mice heart: the role of nitric oxide (NO)

2015 ◽  
Vol 412 (1-2) ◽  
pp. 221-227
Author(s):  
Vesna Milicic ◽  
Vladimir Zivkovic ◽  
Nevena Jeremic ◽  
Nebojsa Arsenijevic ◽  
Dragan Djuric ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Anaphylactic Reaction ◽  
Coronary Flow ◽  
And Oxidative Stress

scholarly journals Low body mass index is a risk factor forimpaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress

2003 ◽  
Vol 42 (2) ◽  
pp. 256-263 ◽  
Author(s):  
Yukihito Higashi ◽  
Shota Sasaki ◽  
Keigo Nakagawa ◽  
Masashi Kimura ◽  
Kensuke Noma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Body Mass Index ◽  
Risk Factor ◽  
Body Mass ◽  
Low Body Mass Index ◽  
And Oxidative Stress

Role of nitric oxide and oxidative stress in ischaemic myocardial injury and preconditioning

2003 ◽  
Vol 58 (2) ◽  
pp. 119-132 ◽  
Author(s):  
An BERGES ◽  
Luc VAN NASSAUW ◽  
Johan BOSMANS ◽  
Jean-Paul TIMMERMANS ◽  
Christiaan VRINTS
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Myocardial Injury ◽  
And Oxidative Stress

scholarly journals Macrophage Mineralocorticoid Receptor Signaling Plays a Key Role in Aldosterone-Independent Cardiac Fibrosis

Endocrinology ◽  
2012 ◽  
Vol 153 (7) ◽  
pp. 3416-3425 ◽  
Author(s):  
Laura A. Bienvenu ◽  
James Morgan ◽  
Amanda J. Rickard ◽  
Greg H. Tesch ◽  
Greg A. Cranston ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Mineralocorticoid Receptor ◽  
Cardiac Fibrosis ◽  
Plasma Aldosterone ◽  
Mrna Levels ◽  
Wild Type ◽  
And Oxidative Stress

Mineralocorticoid receptor (MR) activation promotes the development of cardiac fibrosis and heart failure. Clinical evidence demonstrates that MR antagonism is protective even when plasma aldosterone levels are not increased. We hypothesize that MR activation in macrophages drives the profibrotic phenotype in the heart even when aldosterone levels are not elevated. The aim of the present study was to establish the role of macrophage MR signaling in mediating cardiac tissue remodeling caused by nitric oxide (NO) deficiency, a mineralocorticoid-independent insult. Male wild-type (MRflox/flox) and macrophage MR-knockout (MRflox/flox/LysMCre/+; mac-MRKO) mice were uninephrectomized, maintained on 0.9% NaCl drinking solution, with either vehicle (control) or the nitric oxide synthase (NOS) inhibitor NG-nitro-l-arginine methyl ester (l-NAME; 150 mg/kg/d) for 8 wk. NO deficiency increased systolic blood pressure at 4 wk in wild-type l-NAME/salt-treated mice compared with all other groups. At 8 wk, systolic blood pressure was increased above control in both l-NAME/salt treated wild-type and mac-MRKO mice by approximately 28 mm Hg by l-NAME/salt. Recruitment of macrophages was increased 2- to 3-fold in both l-NAME/salt treated wild-type and mac-MRKO. Inducible NOS positive macrophage infiltration and TNFα mRNA expression was greater in wild-type l-NAME/salt-treated mice compared with mac-MRKO, demonstrating that loss of MR reduces M1 phenotype. mRNA levels for markers of vascular inflammation and oxidative stress (NADPH oxidase 2, p22phox, intercellular adhesion molecule-1, G protein-coupled chemokine receptor 5) were similar in treated wild-type and mac-MRKO mice compared with control groups. In contrast, l-NAME/salt treatment increased interstitial collagen deposition in wild-type by about 33% but not in mac-MRKO mice. mRNA levels for connective tissue growth factor and collagen III were also increased above control treatment in wild-type (1.931 ± 0.215 vs. 1 ± 0.073) but not mac-MRKO mice (1.403 ± 0.150 vs. 1.286 ± 0.255). These data demonstrate that macrophage MR are necessary for the translation of inflammation and oxidative stress into interstitial and perivascular fibrosis after NO deficiency, even when plasma aldosterone is not elevated.

Role of Nitric Oxide and Oxidative Stress in the Development of Renal Failure During Obesity and Preventive Effect of L-Arginine and Antioxidant Diet Supplementation

2010 ◽  
Vol 49 ◽  
pp. S183
Author(s):  
Ana María Gámez Méndez ◽  
Hilda Vargas-Robles ◽  
Mónica Arellano-Mendoza ◽  
Amelia Ríos ◽  
Bruno Escalante-Acosta
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Renal Failure ◽  
Preventive Effect ◽  
Antioxidant Diet ◽  
And Oxidative Stress ◽  
Diet Supplementation

Cholestasis induces apoptosis in mice cardiac cells: the possible role of nitric oxide and oxidative stress

2010 ◽  
Vol 30 (6) ◽  
pp. 898-905 ◽  
Author(s):  
Hamed Shafaroodi ◽  
Farzad Ebrahimi ◽  
Leila Moezi ◽  
Mehrdad Hashemi ◽  
Yousef Doostar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cardiac Cells ◽  
And Oxidative Stress
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