scholarly journals Age‐Related Vascular Endothelial Dysfunction is Associated with Altered Regulation of Nuclear Factor k B and Increased Pro‐Inflammatory Cytokines in Humans

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Anthony J Donato ◽  
Brooke R Lawson ◽  
Kristen L Jablonski ◽  
Lindsey B Gano ◽  
Douglas R Seals
Keyword(s):  
Endothelial Dysfunction ◽  
Inflammatory Cytokines ◽  
Vascular Endothelial ◽  
Nuclear Factor ◽  
Vascular Endothelial Dysfunction ◽  
Age Related ◽  
Altered Regulation ◽  
Pro Inflammatory Cytokines

scholarly journals Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

Circulation ◽  
2009 ◽  
Vol 119 (9) ◽  
pp. 1284-1292 ◽  
Author(s):  
Gary L. Pierce ◽  
Lisa A. Lesniewski ◽  
Brooke R. Lawson ◽  
Stacy D. Beske ◽  
Douglas R. Seals
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Nuclear Factor Κb ◽  
Vascular Endothelial ◽  
Nuclear Factor ◽  
Vascular Endothelial Dysfunction ◽  
Middle Aged

scholarly journals Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function

2017 ◽  
Vol 313 (5) ◽  
pp. H890-H895 ◽  
Author(s):  
Matthew J. Rossman ◽  
Rachelle E. Kaplon ◽  
Sierra D. Hill ◽  
Molly N. McNamara ◽  
Jessica R. Santos-Parker ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Cell Senescence ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Vascular Endothelial Function ◽  
Healthy Humans ◽  
Age Related ◽  
Habitual Exercise

Cellular senescence is emerging as a key mechanism of age-related vascular endothelial dysfunction, but evidence in healthy humans is lacking. Moreover, the influence of lifestyle factors such as habitual exercise on endothelial cell (EC) senescence is unknown. We tested the hypothesis that EC senescence increases with sedentary, but not physically active, aging and is associated with vascular endothelial dysfunction. Protein expression (quantitative immunofluorescence) of p53, a transcription factor related to increased cellular senescence, and the cyclin-dependent kinase inhibitors p21 and p16 were 116%, 119%, and 128% greater (all P < 0.05), respectively, in ECs obtained from antecubital veins of older sedentary (60 ± 1 yr, n = 12) versus young sedentary (22 ± 1 yr, n = 9) adults. These age-related differences were not present (all P > 0.05) in venous ECs from older exercising adults (57 ± 1 yr, n = 13). Furthermore, venous EC protein levels of p53 ( r = −0.49, P = 0.003), p21 ( r = −0.38, P = 0.03), and p16 ( r = −0.58, P = 0.002) were inversely associated with vascular endothelial function (brachial artery flow-mediated dilation). Similarly, protein expression of p53 and p21 was 26% and 23% higher (both P < 0.05), respectively, in ECs sampled from brachial arteries of healthy older sedentary (63 ± 1 yr, n = 18) versus young sedentary (25 ± 1 yr, n = 9) adults; age-related changes in arterial EC p53 and p21 expression were not observed ( P > 0.05) in older habitually exercising adults (59 ± 1 yr, n = 14). These data indicate that EC senescence is associated with sedentary aging and is linked to endothelial dysfunction. Moreover, these data suggest that prevention of EC senescence may be one mechanism by which aerobic exercise protects against endothelial dysfunction with age. NEW & NOTEWORTHY Our study provides novel evidence in humans of increased endothelial cell senescence with sedentary aging, which is associated with impaired vascular endothelial function. Furthermore, our data suggest an absence of age-related increases in endothelial cell senescence in older exercising adults, which is linked with preserved vascular endothelial function. Listen to this article's corresponding podcast at http://ajpheart.podbean.com/e/aging-exercise-and-endothelial-cell-senescence/ .

scholarly journals NOVEL PATHOPHYSIOLOGICAL ROLES OF ALPHA-SYNUCLEIN (SNCA) IN AGE-RELATED VASCULAR ENDOTHELIAL DYSFUNCTION

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e179
Author(s):  
Yoichi Takami ◽  
Hironori Nakagami ◽  
Koichi Yamamoto ◽  
Yasushi Takeya ◽  
Ryuichi Morishita ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Alpha Synuclein ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Age Related

scholarly journals Mitochondria‐targeted antioxidant therapy with MitoQ ameliorates age‐related vascular endothelial dysfunction

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Rachel Anna Gioscia‐Ryan ◽  
Thomas J LaRocca ◽  
Melanie C Zigler ◽  
Michael P Murphy ◽  
Douglas R Seals
Keyword(s):  
Endothelial Dysfunction ◽  
Antioxidant Therapy ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Age Related

Markers of Inflammation, Vascular Endothelial Dysfunction, and Age-related Cataract

2006 ◽  
Vol 141 (1) ◽  
pp. 116-122 ◽  
Author(s):  
Barbara E.K. Klein ◽  
Ronald Klein ◽  
Kristine E. Lee ◽  
Michael D. Knudtson ◽  
Michael Y. Tsai
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Markers Of Inflammation ◽  
Age Related

scholarly journals Role of NFκB in age-related vascular endothelial dysfunction in humans

Aging ◽  
2009 ◽  
Vol 1 (8) ◽  
pp. 678-680 ◽  
Author(s):  
Anthony J. Donato ◽  
Gary L. Pierce ◽  
Lisa A. Lesniewski ◽  
Douglas R. Seals
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Age Related
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