scholarly journals Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

Circulation ◽  
2009 ◽  
Vol 119 (9) ◽  
pp. 1284-1292 ◽  
Author(s):  
Gary L. Pierce ◽  
Lisa A. Lesniewski ◽  
Brooke R. Lawson ◽  
Stacy D. Beske ◽  
Douglas R. Seals
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Nuclear Factor Κb ◽  
Vascular Endothelial ◽  
Nuclear Factor ◽  
Vascular Endothelial Dysfunction ◽  
Middle Aged

Effect of agmatine on experimental vascular endothelial dysfunction

2015 ◽  
Vol 35 (5) ◽  
pp. 573-582 ◽  
Author(s):  
MA Nader ◽  
NM Gamiel ◽  
H El-Kashef ◽  
MS Zaghloul
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Lipid Profile ◽  
Thiobarbituric Acid ◽  
Nuclear Factor Κb ◽  
Cellular Adhesion ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Cellular Adhesion Molecule ◽  
Nitrite Nitrate

This study was designed to investigate the effect of agmatine sulfate (AG, CAS2482-00-0) in nicotine (NIC)-induced vascular endothelial dysfunction (VED) in rabbits. NIC was administered to produce VED in rabbits with or without AG for 6 weeks. Serum lipid profile, serum thiobarbituric acid reactive substances, reduced glutathione, superoxide dismutase generation, serum nitrite/nitrate, serum vascular cellular adhesion molecule-1 (VCAM-1), and aortic nuclear factor κB (NF-κB) levels were analyzed.Treatment with AG markedly improves lipid profile and prevented NIC-induced VED and oxidative stress. The mechanism of AG in improving NIC-induced VED may be due to the significant reduction in serum VCAM-1 levels and aortic NF-κB. Thus, it may be concluded that AG reduces the oxidative stress, nitric oxide production, VCAM-1 levels, and aortic NF-κB expression, thereby consequently improving the integrity of vascular endothelium.

Metformin prevents hyperglycaemia-associated, oxidative stress-induced vascular endothelial dysfunction: essential role for the orphan nuclear receptor, Nr4a1 (Nur77).

2021 ◽  
pp. MOLPHARM-AR-2020-000148
Author(s):  
Vivek Krishna Pulakazhi Venu ◽  
Mahmoud Saifeddine ◽  
Koichiro Mihara ◽  
Muniba Faiza ◽  
Evgueni Gorobets ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Nuclear Receptor ◽  
Essential Role ◽  
Vascular Endothelial ◽  
Orphan Nuclear Receptor ◽  
Vascular Endothelial Dysfunction

scholarly journals Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

Aging Cell ◽  
2010 ◽  
Vol 9 (3) ◽  
pp. 304-312 ◽  
Author(s):  
Catarina Rippe ◽  
Lisa Lesniewski ◽  
Melanie Connell ◽  
Thomas LaRocca ◽  
Anthony Donato ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Calorie Restriction ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Short Term ◽  
Old Mice
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