scholarly journals Women with gestational diabetes mellitus (GDM) have breast milk with lower concentration of docosahexaenoic acid (DHA) compared to women without GDM

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Julissa Marisel Salguero ◽  
Emily Fontenot ◽  
Alicia Page ◽  
Holiday Durham ◽  
Olivia Servan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Breast Milk ◽  
Docosahexaenoic Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus

Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus

2013 ◽  
Vol 305 (7) ◽  
pp. E826-E833 ◽  
Author(s):  
Ana Pagán ◽  
María T. Prieto-Sánchez ◽  
José E. Blanco-Carnero ◽  
Alfonso Gil-Sánchez ◽  
Juan J. Parrilla ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Docosahexaenoic Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Placental Transfer ◽  
Elective Caesarean Section ◽  
Maternal Plasma ◽  
Chain Polyunsaturated Fatty Acid ◽  
Pufa Supplementation ◽  
Plasma Ratio

Better knowledge on the disturbed mechanisms implicated in materno-fetal long-chain polyunsaturated fatty acid (LC-PUFA) transfer in pregnancies with gestational diabetes mellitus (GDM) may have potentially high implications for later on in effective LC-PUFA supplementation. We studied in vivo placental transfer of fatty acids (FA) using stable isotope tracers administrated to 11 control and 9 GDM pregnant women (6 treated with insulin). Subjects received orally [13C]palmitic, [13C]oleic and [13C]linoleic acids, and [13C]docosahexaenoic acid (13C-DHA) 12 h before elective caesarean section. Maternal blood samples were collected at −12, −3, −2, and −1 h, delivery, and +1 h. Placental tissue and venous cord blood were also collected. FA were quantified by gas chromatography (GC) and 13C enrichments by GC-isotope ratio mass spectrometry. [13C]FA concentration was higher in total lipids of maternal plasma in GDM vs. controls, except for [13C]DHA. Moreover, [13C]DHA showed lower placenta/maternal plasma ratio in GDM vs. controls and significantly lower cord/maternal plasma ratio. For the other studied FA, ratios were not different between GDM and controls. Disturbed [13C]DHA placental uptake occurs in both GDM treated with diet or insulin, whereas the last ones also have lower [13C]DHA in venous cord. The tracer study pointed toward impaired placental DHA uptake as critical step, whereas the transfer of the rest of [13C]FA was less affected. GDM under insulin treatment could also have higher fetal fat storage, contributing to reduce [13C]DHA in venous cord. DHA transfer to the fetus was reduced in GDM pregnancies compared with controls, which might affect the programming of neurodevelopment in their neonates.

scholarly journals Docosahexaenoic Acid (DHA) Supplementation Benefits Pregnancy Complicated with Gestational Diabetes Mellitus (GDM)

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Carol J. Lammi‐Keefe ◽  
Jaime Rozowski ◽  
Carmen Gloria Parodi ◽  
Luis Sobrevia ◽  
Rocio Foncea
Keyword(s):  
Diabetes Mellitus ◽  
Docosahexaenoic Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus

scholarly journals Supplementation with Docosahexaenoic Acid (DHA) in Women with Gestational Diabetes Mellitus (GDM) in Chile: Benefit to Glucose Tolerance and Plasma Lipids

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Carol J Lammi‐Keefe ◽  
Carmen Gloria Parodi ◽  
Rocio Foncea ◽  
Luis Sobrevia ◽  
Marcelo Gonzalez ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Docosahexaenoic Acid ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Plasma Lipids

Abstract #1012: Gestational Diabetes Mellitus (GDM) in Bangladesh

2016 ◽  
Vol 22 ◽  
pp. 233-234
Author(s):  
Md Abdullah Mamun ◽  
Subrina Jesmin ◽  
Md. Arifur Rahman ◽  
Md Majedul Islam ◽  
Farzana Sohael ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus
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