Age‐related changes in autonomic control during sleep: symbolic and complexity analyses of heart rate variability

ObjectiveThe aim of this study was to assess age-related changes in cardiac autonomic modulation and heart rate variability (HRV) and their association with spontaneous and pharmacologically induced vulnerability to cardiac arrhythmias, to verify the translational relevance of mouse models for further in-depth evaluation of the link between autonomic changes and increased arrhythmic risk with advancing age.MethodsHeart rate (HR) and time- and frequency-domain indexes of HRV were calculated from Electrocardiogram (ECG) recordings in two groups of conscious mice of different ages (4 and 19 months old) (i) during daily undisturbed conditions, (ii) following peripheral β-adrenergic (atenolol), muscarinic (methylscopolamine), and β-adrenergic + muscarinic blockades, and (iii) following β-adrenergic (isoprenaline) stimulation. Vulnerability to arrhythmias was evaluated during daily undisturbed conditions and following β-adrenergic stimulation.ResultsHRV analysis and HR responses to autonomic blockades revealed that 19-month-old mice had a lower vagal modulation of cardiac function compared with 4-month-old mice. This age-related autonomic effect was not reflected in changes in HR, since intrinsic HR was lower in 19-month-old compared with 4-month-old mice. Both time- and frequency-domain HRV indexes were reduced following muscarinic, but not β-adrenergic blockade in younger mice, and to a lesser extent in older mice, suggesting that HRV is largely modulated by vagal tone in mice. Finally, 19-month-old mice showed a larger vulnerability to both spontaneous and isoprenaline-induced arrhythmias.ConclusionThe present study combines HRV analysis and selective pharmacological autonomic blockades to document an age-related impairment in cardiac vagal modulation in mice which is consistent with the human condition. Given their short life span, mice could be further exploited as an aged model for studying the trajectory of vagal decline with advancing age using HRV measures, and the mechanisms underlying its association with proarrhythmic remodeling of the senescent heart.

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Wavelet transform shows age-related changes of heart rate variability within independent frequency components

Autonomic Neuroscience ◽

10.1016/j.autneu.2005.10.004 ◽

2005 ◽

Vol 123 (1-2) ◽

pp. 94-100 ◽

Cited By ~ 29

Author(s):

Daniel E. Vigo ◽

Salvador M. Guinjoan ◽

Mariano Scaramal ◽

Leonardo Nicola Siri ◽

Daniel P. Cardinali

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Wavelet Transform ◽

Age Related ◽

Frequency Components ◽

Age Related Changes

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Age-Related Changes of Heart Rate Variability at Various Insulin Sensitivity and Telomere Length

Kardiologiia ◽

10.18087/cardio.2017.7.10006 ◽

2017 ◽

Vol 17 (7) ◽

pp. 52-60 ◽

Cited By ~ 1

Author(s):

L. I. Streltsova ◽

◽

O. N. Tkachyeva ◽

E. N. Dudinskaya ◽

D. U. Akasheva ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Insulin Sensitivity ◽

Telomere Length ◽

Age Related ◽

Age Related Changes

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Comparative characteristics of heart rate variability parameters of Yugra pupils

Complexity Mind Postnonclassic ◽

10.12737/12006 ◽

2015 ◽

Vol 4 (2) ◽

pp. 11-20

Author(s):

Химикова ◽

O. Khimikova ◽

Эльман ◽

Kseniya Elman ◽

Бурыкин ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Multivariate Analysis ◽

Comparative Analysis ◽

Multiple Comparisons ◽

The Body ◽

Age Group ◽

Migrant Population ◽

Age Related ◽

Age Related Changes

This article presents a comparative analysis of the parameters of HRV students who are indigenous and non-indigenous residents of Yugra. Analysis was carried out carried out by multiple comparisons of three age subgroups and by multivariate analysis with the calculation of inter-cluster distances. The differences in the dynamics of age-related changes of Yugra schoolchildren reveals distinctive trend parameters of heart rate variability between indigenous and non-indigenous representatives of North. In particular, it revealed a higher adaptive capacity in Aboriginal representatives in comparison with the migrant population. The maximum divergence of parameters of the body boys observed in the older age group.

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P2.13 Age-related changes in autonomic cardiac control during sleep: Non linear and complexity analyses of heart rate variability

Autonomic Neuroscience ◽

10.1016/j.autneu.2009.05.142 ◽

2009 ◽

Vol 149 (1-2) ◽

pp. 78-79

Author(s):

E. Tobaldini ◽

A.U. Viola ◽

S.L. Chellappa ◽

A. Porta ◽

K.R. Casali ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Cardiac Control ◽

Age Related ◽

Non Linear ◽

Age Related Changes

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AGE-RELATED CHANGES IN HEART RATE VARIABILITY AND THEIR RELATION WITH LEUCOCYTE TELOMERE LENGTH

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2017-1-54-60 ◽

2017 ◽

Vol 16 (1) ◽

pp. 54-60 ◽

Cited By ~ 2

Author(s):

L. I. Streltsova ◽

О. N. Tkacheva ◽

E. V. Plokhova ◽

D. U. Akasheva ◽

I. D. Strajesko ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Telomere Length ◽

Age Related ◽

Age Related Changes

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Age-related changes in nonlinear component of 24-hour heart rate variability.

Japanese Journal of Electrocardiology ◽

10.5105/jse.18.203 ◽

1998 ◽

Vol 18 (2) ◽

pp. 203-209

Author(s):

Seiichiro Sakata ◽

Junichiro Hayano ◽

Seiji Mukai ◽

Akiyoshi Okada ◽

Takao Fujinami

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Nonlinear Component ◽

Age Related ◽

Age Related Changes

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Cortisol Levels and Autonomic Control of Heart Rate in Healthy Subjects

Acta Medica Martiniana ◽

10.1515/acm-2017-0006 ◽

2017 ◽

Vol 17 (2) ◽

pp. 5-14 ◽

Cited By ~ 1

Author(s):

Milana Drumond Ramos Santana ◽

Eli Carlos Martiniano ◽

Larissa Raylane Lucas Monteiro ◽

Maria Do Socorro Santos De Oliveira ◽

Vitor E. Valenti ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Heart Rate Variability ◽

Salivary Cortisol ◽

Healthy Subjects ◽

Autonomic Control ◽

Autonomic Modulation ◽

Cardiac Autonomic Modulation ◽

Cortisol Levels ◽

Modulation Methods

AbstractIntroduction: There is an increase in level of stress in the general population because of the social, personal and professional demands. Currently, there are only simple tools that can safely measure this stress such as levels of cortisol and heart rate variability (HRV). Objective: To analyze the relationship between salivary cortisol and the cardiac autonomic modulation. Methods: A total of fifty-one male and female subjects between 18 and 40 years old were evaluated. Saliva collection was achieved for the salivary cortisol dosage. The collection was performed through the SalivetteR tube. After this collection, the median cortisol levels (0.24 ug/dl) were analyzed and the volunteers were divided into two groups: i) cortisol below the mediane ii) cortisol above the median. After this division, each group consisted of 25 volunteers and then was verified the following information: age, gender, weight, height, body mass index (BMI), blood pressure. Shortly thereafter was assessment of cardiac autonomic modulation por meio da HRV. The Polar RS800cx heart rate receiver was placed on the chest of the volunteers, in the vicinity of the distal third of the sternum. The volunteers were instructed to remain in rest with spontaneous breathing in dorsal position for 20 minutes. HRV analysis included geometric, time and frequency domain indices. Results: There were no statistical differences for the two groups regarding systolic and diastolic blood pressure, heart rate, RR intervals or linear and frequency indices for the volunteers. In addition, also there was no correlation the cortisol with the analyzed variables (SAP, p=0.460; DAP, p = 0.270; HR, p = 0.360; RR, p = 0.380; SDNN, p = 0.510; rMSSD, p = 0.660; pNN50, p = 0.820; RRtri, p = 0.170; TINN, p = 0.470; SD1, p = 0.650; SD2, p = 0.500; LF [ms2], p = 0.880; LF [nu], p = 0.970; HF [ms2], p = 0.870; HF [nu], p = 0.960; LF/HF, p = 0.380 Conclusion: Heart rate variability autonomic control was unchanged in healthy subjects with physiological distribution of salivary cortisol levels. There was no association between normal salivary cortisol and resting autonomic regulation of heart rate.

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