scholarly journals Interaction of the effects between estrogen receptor‐alpha polymorphism and physical activity or nutrient on bone mass in Japanese young women

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Hiroyo Kondo ◽  
Hidemi Fujino ◽  
Shinichiro Murakami ◽  
Isao Takeda ◽  
Akihiko Ishihara
Keyword(s):  
Physical Activity ◽  
Estrogen Receptor ◽  
Bone Mass ◽  
Young Women ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha

Mice lacking estrogen receptor [alpha] in hypothalamic POMC neurons display enhanced estrogenic response on cortical bone mass

2016 ◽  
Author(s):  
Helen Farman ◽  
Sara Windahl ◽  
Deborah Clegg ◽  
Shang Kui Xie ◽  
Lars Westberg ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bone Mass ◽  
Cortical Bone ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Cortical Bone Mass

scholarly journals Female Mice Lacking Estrogen Receptor-Alpha in Osteoblasts Have Compromised Bone Mass and Strength

2014 ◽  
Vol 29 (2) ◽  
pp. 370-379 ◽  
Author(s):  
Katherine M Melville ◽  
Natalie H Kelly ◽  
Sohaib A Khan ◽  
John C Schimenti ◽  
F Patrick Ross ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bone Mass ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Female Mice

scholarly journals Estrogen receptor‐alpha genotype affects exercise‐related bone mass in young healthy women

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Hiroyo Kondo ◽  
Hidemi Fujino ◽  
Shinichiro Murakami ◽  
Naoto Fujita ◽  
Fumiko Nagatomo ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bone Mass ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Healthy Women

scholarly journals Vitamin D receptor and Estrogen receptor alpha Genotype affects Exercise related Bone mass in Japanese healthy women

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Hiroyo Kondo ◽  
Hidemi Fujino ◽  
Shinichiro Murakami ◽  
Naoto Fujita ◽  
Fumiko Nagatomo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Estrogen Receptor ◽  
Bone Mass ◽  
Vitamin D Receptor ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Healthy Women

scholarly journals Lack of Association of Estrogen Receptor Alpha Gene Polymorphisms with Cardiorespiratory and Metabolic Variables in Young Women

2012 ◽  
Vol 13 (12) ◽  
pp. 13691-13703 ◽  
Author(s):  
Ana Cristina Rebelo ◽  
Rozangela Verlengia ◽  
Vandeni Kunz ◽  
Nayara Tamburus ◽  
Alvaro Cerda ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Young Women ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Estrogen Receptor Alpha Gene ◽  
Alpha Gene ◽  
Metabolic Variables

Arginine site 264 in murine estrogen receptor alpha is dispensable for the regulation of the skeleton

2020 ◽  
Author(s):  
Karin L. Gustafsson ◽  
Helen H. Farman ◽  
Karin H. Nilsson ◽  
Petra Henning ◽  
Sofia Movérare-Skrtic ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bone Mass ◽  
Trabecular Bone ◽  
Cortical Thickness ◽  
Intracellular Signaling ◽  
Estrogen Receptor Alpha ◽  
Estrogen Treatment ◽  
Receptor Alpha ◽  
Trabecular Bone Mass

Estrogen protects against bone loss, but is not a suitable treatment due to adverse effects in other tissues. Increased knowledge regarding estrogen signaling in estrogen-responsive tissues is therefore warranted to aid the development of bone-specific estrogen treatments. Estrogen receptor alpha (ERα), the main mediator of estrogenic effects in bone, is widely subjected to posttranslational modifications (PTMs). In vitro studies have shown that methylation at site R260 in the human ERα affects receptor localization and intracellular signaling. The corresponding amino acid R264 in murine ERα has been shown to have a functional role in endothelium in vivo; albeit the methylation of R264 in the murine gene is yet to be empirically demonstrated. The aim of this study was to investigate if R264 in ERα is involved in the regulation of the skeleton in vivo. DXA analysis at three, six, nine, and twelve months of age showed no differences in total body areal BMD between R264A and WT in either female or male mice. Furthermore, analyses using CT demonstrated that trabecular bone mass in tibia and vertebra, and cortical thickness in tibia, were similar between R264A and WT mice. In addition, R264A females displayed a normal estrogen treatment response in trabecular bone mass, as well as in cortical thickness. Furthermore, uterus, thymus, and adipose tissue responded similarly in R264A and WT female mice after estrogen treatment. In conclusion, our novel finding that mutation of R264 in ERα does not affect the regulation of the skeleton, together with the known role of R264 for ERα-mediated endothelial effects, supports the concept that R264 determines tissue specificity of ERα.

scholarly journals Testosterone and the Male Skeleton: A Dual Mode of Action

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Mieke Sinnesael ◽  
Steven Boonen ◽  
Frank Claessens ◽  
Evelien Gielen ◽  
Dirk Vanderschueren
Keyword(s):  
Estrogen Receptor ◽  
Androgen Receptor ◽  
Bone Mass ◽  
Bone Turnover ◽  
Mode Of Action ◽  
Estrogen Receptor Alpha ◽  
Receptor Activation ◽  
Male Mice ◽  
Dual Mode ◽  
Receptor Alpha

Testosterone is an important hormone for both bone gain and maintenance in men. Hypogonadal men have accelerated bone turnover and increased fracture risk. In these men, administration of testosterone inhibits bone resorption and maintains bone mass. Testosterone, however, is converted into estradiol via aromatization in many tissues including male bone. The importance of estrogen receptor alpha activation as well of aromatization of androgens into estrogens was highlighted by a number of cases of men suffering from an inactivating mutation in the estrogen receptor alpha or in the aromatase enzyme. All these men typically had low bone mass, high bone turnover and open epiphyses. In line with these findings, cohort studies have confirmed that estradiol contributes to the maintenance of bone mass after reaching peak bone mass, with an association between estradiol and fractures in elderly men. Recent studies in knock-out mice have increased our understanding of the role of androgens and estrogens in different bone compartments. Estrogen receptor activation, but not androgen receptor activation, is involved in the regulation of male longitudinal appendicular skeletal growth in mice. Both the androgen and the estrogen receptor can independently mediate the cancellous bone-sparing effects of sex steroids in male mice. Selective KO studies of the androgen receptor in osteoblasts in male mice suggest that the osteoblast in the target cell for androgen receptor mediated maintenance of trabecular bone volume and coordination of bone matrix synthesis and mineralization. Taken together, both human and animal studies suggest that testosterone has a dual mode of action on different bone surfaces with involvement of both the androgen and estrogen receptor.

Estrogen Receptor-alpha Genotype Affects Exercise And Nutrient Intake-related Change Of Bone Mass.

2009 ◽  
Vol 41 ◽  
pp. 202
Author(s):  
Hiroyo Kondo ◽  
Hidemi Fujino ◽  
Takuro Funahashi ◽  
Koji Suzuki
Keyword(s):  
Estrogen Receptor ◽  
Bone Mass ◽  
Nutrient Intake ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha
Sign in / Sign up

Export Citation Format

Share Document