scholarly journals Insulin growth factor 2 mRNA binding protein 1 (IGF2BP1) regulates translation of the multidrug resistance protein 2 (MRP2) by binding to its 5′‐untranslated region (5′UTR)

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Mary Vore ◽  
Tianyong Zhao ◽  
Yanbin Zhang ◽  
Baoxiang Yan ◽  
Sunnie R Thompson
Keyword(s):  
Multidrug Resistance ◽  
Growth Factor ◽  
Untranslated Region ◽  
Binding Protein ◽  
Multidrug Resistance Protein ◽  
Insulin Growth Factor ◽  
Multidrug Resistance Protein 2 ◽  
Mrna Binding Protein ◽  
Resistance Protein ◽  
Mrna Binding

scholarly journals Human Insulin Growth Factor 2 mRNA Binding Protein 2 Increases MicroRNA 33a/b Inhibition of Liver ABCA1 Expression and Alters Low-Density Apolipoprotein Levels in Mice

2020 ◽  
Vol 40 (16) ◽  
Author(s):  
Muhua Yang ◽  
Christina Gallo-Ebert ◽  
Michael Hayward ◽  
Weidong Liu ◽  
Virginia McDonough ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Association Studies ◽  
Blood Levels ◽  
Genome Wide Association Studies ◽  
Low Density ◽  
Nucleotide Polymorphisms ◽  
Insulin Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding

ABSTRACT Genome-wide association studies (GWAS) have linked IGF2BP2 single-nucleotide polymorphisms (SNPs) with type 2 diabetes (T2D). Mice overexpressing mIGF2BP2 have elevated cholesterol levels when fed a diet that induces hepatic steatosis. These and other studies suggest an important role for insulin growth factor 2 mRNA binding protein 2 (IGF2BP2) in the initiation and progression of several metabolic disorders. The ATPase binding cassette protein ABCA1 initiates nascent high-density apolipoprotein (HDL) biogenesis by transferring phospholipid and cholesterol to delipidated apolipoprotein AI (ApoAI). Individuals with mutational ablation of ABCA1 have Tangier disease, which is characterized by a complete loss of HDL. MicroRNA 33a and 33b (miR-33a/b) bind to the 3′ untranslated region (UTR) of ABCA1 and repress its posttranscriptional gene expression. Here, we show that IGF2BP2 works together with miR-33a/b in repressing ABCA1 expression. Our data suggest that IGF2BP2 is an accessory protein of the argonaute (AGO2)–miR-33a/b–RISC complex, as it directly binds to miR-33a/b, AGO2, and the 3′ UTR of ABCA1. Finally, we show that mice overexpressing human IGF2BP2 have decreased ABCA1 expression, increased low-density lipoprotein-cholesterol (LDL-C) and cholesterol blood levels, and elevated SREBP-dependent signaling. Our data support the hypothesis that IGF2BP2 has an important role in maintaining lipid homeostasis through its modulation of ABCA1 expression, as its overexpression or loss leads to dyslipidemia.

scholarly journals Multidrug Resistance Protein 2 Implicates Anticancer Drug-Resistance to Sorafenib

2011 ◽  
Vol 34 (3) ◽  
pp. 433-435 ◽  
Author(s):  
Yoshihiko Shibayama ◽  
Kou Nakano ◽  
Hiroshi Maeda ◽  
Miyuki Taguchi ◽  
Ryuji Ikeda ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Multidrug Resistance ◽  
Anticancer Drug ◽  
Multidrug Resistance Protein ◽  
Multidrug Resistance Protein 2 ◽  
Resistance Protein ◽  
Anticancer Drug Resistance

scholarly journals Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Xinwei Huang ◽  
Hong Zhang ◽  
Xiaoran Guo ◽  
Zongxin Zhu ◽  
Haibo Cai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding

The roles of Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3) in melanoma progression

2013 ◽  
Vol 69 (2) ◽  
pp. e20-e21
Author(s):  
Chia-Yu Chu ◽  
Yi-Shuan Sheen ◽  
Kuanyin K. Lin ◽  
Meng-Chen Hsieh ◽  
Hsien-Ching Chiu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Messenger Rna ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Melanoma Progression ◽  
Factor Ii ◽  
Mrna Binding Protein ◽  
Mrna Binding

scholarly journals Regorafenib Is Transported by the Organic Anion Transporter 1B1 and the Multidrug Resistance Protein 2

2015 ◽  
Vol 38 (4) ◽  
pp. 582-586 ◽  
Author(s):  
Hiroki Ohya ◽  
Yoshihiko Shibayama ◽  
Jiro Ogura ◽  
Katsuya Narumi ◽  
Masaki Kobayashi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Multidrug Resistance Protein ◽  
Multidrug Resistance Protein 2 ◽  
Anion Transporter ◽  
Resistance Protein
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