scholarly journals Protective role of HSF1 and HSP70 in rat testis apoptotic cells exposed to chronic hypobaric hypoxia

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Jorge G. Farias ◽  
Daniela Oyarzun ◽  
Andrea Zepeda
Keyword(s):  
Hypobaric Hypoxia ◽  
Protective Role ◽  
Apoptotic Cells ◽  
Rat Testis

Oxidative Stress in Rat Testis and Epididymis Under Intermittent Hypobaric Hypoxia: Protective Role of Ascorbate Supplementation

2010 ◽  
Vol 31 (3) ◽  
pp. 314-321 ◽  
Author(s):  
J. G. Farias ◽  
M. Puebla ◽  
A. Acevedo ◽  
P. J. Tapia ◽  
E. Gutierrez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hypobaric Hypoxia ◽  
Protective Role ◽  
Rat Testis ◽  
Intermittent Hypobaric Hypoxia

scholarly journals The protective role of 5-hydroxymethyl-2-furfural (5-HMF) against acute hypobaric hypoxia

2011 ◽  
Vol 16 (5) ◽  
pp. 529-537 ◽  
Author(s):  
Ming-Ming Li ◽  
Li-Ying Wu ◽  
Tong Zhao ◽  
Kui-Wu Wu ◽  
Lei Xiong ◽  
...  
Keyword(s):  
Hypobaric Hypoxia ◽  
Protective Role ◽  
Acute Hypobaric Hypoxia

scholarly journals Rat Spermatogenesis Damage in Intermittent Hypobaric Hypoxia and the Protective Role of Melatonin. II: Testicular Parameters

2010 ◽  
Vol 28 (2) ◽  
Author(s):  
Eduardo Bustos-Obregón ◽  
Rodrigo Castro-Sánchez ◽  
Benito Ramos-González ◽  
Leandro Torres-Díaz
Keyword(s):  
Hypobaric Hypoxia ◽  
Protective Role ◽  
Intermittent Hypobaric Hypoxia ◽  
Rat Spermatogenesis

scholarly journals Protective role of hesperidin against γ-radiation-induced oxidative stress and apoptosis in rat testis

2017 ◽  
Vol 24 (1) ◽  
Author(s):  
Nadia Z. Shaban ◽  
Ahmed M. Ahmed Zahran ◽  
Fatma H. El-Rashidy ◽  
Ahmad S. Abdo Kodous
Keyword(s):  
Oxidative Stress ◽  
Protective Role ◽  
Γ Radiation ◽  
Rat Testis ◽  
Radiation Induced

scholarly journals Preliminary Investigation on the Ameliorative Role Exerted by D-Aspartic Acid in Counteracting Ethane Dimethane Sulfonate (EDS) Toxicity in the Rat Testis

Animals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 133
Author(s):  
Massimo Venditti ◽  
Maria Zelinda Romano ◽  
Francesco Aniello ◽  
Sergio Minucci
Keyword(s):  
Aspartic Acid ◽  
Morphological Changes ◽  
Preliminary Investigation ◽  
Environmental Pollutants ◽  
Reproductive Function ◽  
Serum Testosterone ◽  
Protective Role ◽  
Serum Testosterone Level ◽  
Rat Testis

Herein is reported the first evidence of the protective role of D-aspartic acid (D-Asp) in preventing the toxic effect exerted by the alkylating agent ethane dimethane sulfonate (EDS) in the rat testis. We confirmed that EDS treatment specifically destroyed Leydig cells (LC), resulting in the drastic decrease of the serum testosterone level and producing morphological changes in the germinal tubules, i.e., altered organization of the epithelium, loss of cell contacts and the consequent presence of empty spaces between them, and a reduce number of spermatozoa. Moreover, an increase of TUNEL-positive germ cells, other than alteration in the protein level and localization of two LC “markers”, StAR and PREP, were observed. Interestingly, results obtained from rats pre-treated with D-Asp for 15 days before EDS-injection showed that all the considered parameters were quite normal. To explore the probable mechanism(s) involved in the protection exerted by D-Asp, we considered the increased oxidative stress induced by EDS and the D-Asp antioxidant effects. Thiobarbiturc acid-reactive species (TBARS) levels increased following EDS-injection, while no change was observed in the D-Asp + EDS treated rats. Our results showed that D-Asp may be used as a strategy to mitigate the toxic effects exerted by environmental pollutants, as endocrine disrupters, in order to preserve the reproductive function.

Protective role of peroxiredoxin-4 in heart failure

2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq
Keyword(s):  
Heart Failure ◽  
Cardiac Fibroblasts ◽  
Protective Role ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Galectin 3 ◽  
Consequent Increase ◽  
And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

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