scholarly journals Skeletal Muscle Resistance to Leucine Induced Signal Transduction and Regulation of Autophagy in Acute Kidney Injury (AKI)

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Kevin McIntire ◽  
Yu Chen ◽  
Sumita Sood ◽  
Ralph Rabkin
Keyword(s):  
Skeletal Muscle ◽  
Signal Transduction ◽  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Induced Signal

scholarly journals MP271IMPORTANCE OF SKELETAL MUSCLE MASS ON THE LONG TERM SURVIVAL IN ELDERLY ACUTE KIDNEY INJURY PATIENTS WHO UNDERWENT CONTINUOUS RENAL REPLACEMENT THERAPY

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii527-iii527
Author(s):  
Ihm Soo Kwak ◽  
Harin Rhee ◽  
Il-Young Kim ◽  
Sang-Heon Song ◽  
Eun-Young Seong ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Kidney Injury ◽  
Term Survival

The Effect of PACAP38 on MyD88-Mediated Signal Transduction in Ischemia-/Hypoxia-Induced Acute Kidney Injury

2010 ◽  
Vol 32 (6) ◽  
pp. 522-532 ◽  
Author(s):  
Min Li ◽  
Altaf-M. Khan ◽  
Jerome L. Maderdrut ◽  
Eric E. Simon ◽  
Vecihi Batuman
Keyword(s):  
Signal Transduction ◽  
Acute Kidney Injury ◽  
Kidney Injury

scholarly journals Resuscitation with PEGylated carboxyhemoglobin preserves renal cortical oxygenation and improves skeletal muscle microcirculatory flow during endotoxemia

2020 ◽  
Vol 318 (5) ◽  
pp. F1271-F1283 ◽  
Author(s):  
Philippe Guerci ◽  
Bülent Ergin ◽  
Aslı Kandil ◽  
Yasin Ince ◽  
Paul Heeman ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Acute Kidney Injury ◽  
Plasma Levels ◽  
Kidney Injury ◽  
Albino Rats ◽  
Heme Oxygenase 1 ◽  
Animal Group ◽  
Phosphorescence Quenching ◽  
Time Control ◽  
Microcirculatory Flow

PEGylated carboxyhemoglobin (PEGHbCO), which has carbon monoxide-releasing properties and plasma expansion and oxygen-carrying properties, may improve both skeletal microcirculatory flow and renal cortical microcirculatory Po2 (CµPo2) and, subsequently, limit endotoxemia-induced acute kidney injury. Anesthetized, ventilated Wistar albino rats ( n = 44) underwent endotoxemic shock. CµPo2 was measured in exposed kidneys using a phosphorescence-quenching method. Rats were randomly assigned to the following five groups: 1) unresuscitated lipopolysaccharide (LPS), 2) LPS + Ringer’s acetate (RA), 3) LPS + RA + 0.5 µg·kg·−1min−1 norepinephrine (NE), 4) LPS + RA + 320 mg/kg PEGHbCO, and 5) LPS + RA + PEGHbCO + NE. The total volume was 30 mL/kg in each group. A time control animal group was used. Skeletal muscle microcirculation was assessed by handheld intravital microscopy. Kidney immunohistochemistry and myeloperoxidase-stained leukocytes in glomerular and peritubular areas were analyzed. Endotoxemia-induced histological damage was assessed. Plasma levels of IL-6, heme oxygenase-1, malondialdehyde, and syndecan-1 were assessed by ELISA. CµPo2 was higher in the LPS + RA + PEGHbCO-resuscitated group, at 35 ± 6mmHg compared with 21 ± 12 mmHg for the LPS+RA group [mean difference: −13.53, 95% confidence interval: (−26.35; −0.7156), P = 0.035]. The number of nonflowing, intermittent, or sluggish capillaries was smaller in groups infused with PEGHbCO compared with RA alone ( P < 0.05), while the number of normally perfused vessels was greater ( P < 0.05). The addition of NE did not further improve CµPo2 or microcirculatory parameters. Endotoxemia-induced kidney immunohistochemistry and histological alterations were not mitigated by PEGHbCO 1 h after resuscitation. Renal leukocyte infiltration and plasma levels of biomarkers were similar across groups. PEGHbCO enhanced CµPo2 while restoring skeletal muscle microcirculatory flow in previously nonflowing capillaries. PEGHbCO should be further evaluated as a resuscitation fluid in mid- to long-term models of sepsis-induced acute kidney injury.

scholarly journals Acute uremia suppresses leucine-induced signal transduction in skeletal muscle

2014 ◽  
Vol 85 (2) ◽  
pp. 374-382 ◽  
Author(s):  
Kevin L. McIntire ◽  
Yu Chen ◽  
Sumita Sood ◽  
Ralph Rabkin
Keyword(s):  
Skeletal Muscle ◽  
Signal Transduction ◽  
Induced Signal

An Unusual Cause of Myoglobinuria

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Skeletal Muscle ◽  
Acute Kidney Injury ◽  
Lactate Dehydrogenase ◽  
Physical Therapy ◽  
Muscle Cell ◽  
Rare Case ◽  
Creatine Phosphokinase ◽  
Kidney Injury ◽  
Acute Rhabdomyolysis ◽  
Specific Muscle

Rhabdomyolysis is characterized by the acute breakdown of skeletal muscle, resulting in the release of muscle cell contents like myoglobin, creatine phosphokinase (CK) and lactate dehydrogenase, which can lead to acute kidney injury in severe cases. A number of etiologies have been identified in acute rhabdomyolysis including hereditary and acquired of which drugs and trauma account for the majority of cases [1]. Physical therapy is frequently prescribed and generally considered safe for weakness; deconditioning and non - specific muscle aches. Rhabdomyolysis following a massage session is unheard of. However we report a rare case of rhabdomyolysis with acute kidney injury following an aggressive massage session.

scholarly journals Skeletal Muscle-Derived Stem/Progenitor Cells: A Potential Strategy for the Treatment of Acute Kidney Injury

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Egle Pavyde ◽  
Romaldas Maciulaitis ◽  
Mykolas Mauricas ◽  
Gintaras Sudzius ◽  
Ernesta Ivanauskaite Didziokiene ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Acute Kidney Injury ◽  
Progenitor Cells ◽  
Therapeutic Potential ◽  
Kidney Injury ◽  
Population Doubling ◽  
Population Doubling Time ◽  
Isolation Technique ◽  
Time Flow ◽  
Potential Strategy

Skeletal muscle-derived stem/progenitor cells (MDSPCs) have been thoroughly investigated and already used in preclinical studies. However, therapeutic potential of MDSPCs isolated using preplate isolation technique for acute kidney injury (AKI) has not been evaluated. We aimed to characterize rat MDSPCs, compare them with bone marrow mesenchymal stem cells (BM-MSCs), and evaluate the feasibility of MDSPCs therapy for gentamicin-induced AKI in rats. We have isolated and characterized rat MDSPCs and BM-MSCs. Characteristics of rat BM-MSCs and MDSPCs were assessed by population doubling time, flow cytometry, immunofluorescence staining, RT-PCR, and multipotent differentiation capacity. Gentamicin-induced AKI model in rat was used to examine MDSPCs therapeutic effect. Physiological and histological kidney parameters were determined. MDSPCs exhibited similar immunophenotype, stem cell gene expression, and multilineage differentiation capacities as BM-MSCs, but they demonstrated higher proliferation rate. Single intravenous MDSPCs injection accelerated functional and morphological kidney recovery, as reflected by significantly lower serum creatinine levels, renal injury score, higher urinary creatinine, and GFR levels. PKH-26-labeled MDSPCs were identified within renal cortex 1 and 2 weeks after cell administration, indicating MDSPCs capacity to migrate and populate renal tissue. In conclusion, MDSPCs are capable of mediating functional and histological kidney recovery and can be considered as potential strategy for AKI treatment.

Coronavirus disease 2019 presenting with rhabdomyolysis

2020 ◽  
pp. 201010582094391
Author(s):  
Trina Jo Mah ◽  
Ying Hui Lum ◽  
Bingwen Eugene Fan
Keyword(s):  
Skeletal Muscle ◽  
Acute Kidney Injury ◽  
Early Treatment ◽  
Clinical Condition ◽  
Viral Infections ◽  
Kidney Injury ◽  
Young Male ◽  
Intravenous Hydration

Rhabdomyolysis is a clinical condition characterised by the breakdown of skeletal muscle. It has been attributed to viral infections. We describe a case of coronavirus disease 2019 (COVID-19) in a young male who presented with rhabdomyolysis. Myalgia and fatigue are common complaints in COVID-19 patients. We suggest that patients with COVID-19 be screened for rhabdomyolysis in order to facilitate early treatment with intravenous hydration, thus preventing complications such as acute kidney injury.

Rhabdomyolysis

2016 ◽  
Author(s):  
Anthony Baldea
Keyword(s):  
Skeletal Muscle ◽  
Acute Kidney Injury ◽  
Creatine Kinase ◽  
Compartment Syndrome ◽  
Kidney Injury ◽  
Serum Creatine Kinase ◽  
Intravascular Volume ◽  
Adequate Hydration ◽  
Early Use ◽  
High Level

Rhabdomyolysis is a condition that results from the breakdown of skeletal muscle. The etiologies can be broken down into three main categories of causes: traumatic, atraumatic exertional, and atraumatic nonexertional. Patients with rhabdomyolysis often present with myalgia and are found to have myoglobinuria with elevations in serum creatine kinase levels. The mainstay in therapy is focused on restoration of intravascular volume with large-volume fluid resuscitation using isotonic fluids. Adequate hydration is necessary to prevent the potential complications of rhabdomyolysis, including the development of acute kidney injury. Practitioners should maintain a high level of suspicion of compartment syndrome in patients with rhabdomyolysis. If extremity compartment syndrome is diagnosed, prompt decompressive fasciotomies should be performed to preserve muscle and nerve viability. The early use of renal replacement therapy in patients with rhabdomyolysis has been described in the literature and may represent another modality of therapy to prevent the adverse sequelae of rhabdomyolysis. Key words: acute kidney injury, compartment syndrome, creatine kinase, disseminated intravascular coagulation, rhabdomyolysis

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