scholarly journals Chicken ovalbumin upstream promoter transcription factor II regulates the expression of retinoic acid receptors and retinoid X receptors in hepatocytes

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Rui Li ◽  
Guoxun Chen
Keyword(s):  
Transcription Factor ◽  
Retinoic Acid ◽  
Retinoic Acid Receptors ◽  
Retinoid X Receptors ◽  
Factor Ii ◽  
Upstream Promoter ◽  
X Receptors ◽  
Chicken Ovalbumin

scholarly journals Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.

1992 ◽  
Vol 12 (9) ◽  
pp. 4153-4163 ◽  
Author(s):  
A J Cooney ◽  
S Y Tsai ◽  
B W O'Malley ◽  
M J Tsai
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Retinoic Acid ◽  
Thyroid Hormone ◽  
Dna Binding ◽  
Vitamin D3 ◽  
Retinoic Acid Receptors ◽  
Response Elements ◽  
Upstream Promoter ◽  
Chicken Ovalbumin

Alignment of natural chicken ovalbumin upstream promoter transcription factor (COUP-TF) response elements shows that, in addition to the predominant direct repeat of the GGTCA motif with a 2-bp spacing, there are other functional COUP elements with variations in the GGTCA orientation and spacing. We systematically analyzed the binding of in vitro-synthesized COUP-TFs and showed that COUP-TF is capable of binding to oligonucleotides containing both direct repeats and palindromes and with different spacings of the GGTCA repeats. Subsequently, we analyzed four possible mechanisms proposed to explain how COUP-TF could bind to these spatial variations of the GGTCA repeat. We demonstrated that the functional DNA-binding form of COUP-TF is a dimer which requires two GGTCA half-sites to bind DNA. We demonstrated that the COUP-TF dimer undergoes a remarkable structural adaptation to accommodate binding to these spatial variants of the GGTCA repeats. A functional consequence of the promiscuous DNA binding of COUP-TF is its ability to down-regulate hormonal induction of target gene expression by other members of the steroid-thyroid hormone receptor superfamily such as the vitamin D3, thyroid hormone, and retinoic acid receptors. Our data indicate that COUP-TF may have an important role in hormonal regulation of gene expression by these receptors.

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors

1992 ◽  
Vol 12 (9) ◽  
pp. 4153-4163
Author(s):  
A J Cooney ◽  
S Y Tsai ◽  
B W O'Malley ◽  
M J Tsai
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Retinoic Acid ◽  
Thyroid Hormone ◽  
Dna Binding ◽  
Vitamin D3 ◽  
Retinoic Acid Receptors ◽  
Response Elements ◽  
Upstream Promoter ◽  
Chicken Ovalbumin

Alignment of natural chicken ovalbumin upstream promoter transcription factor (COUP-TF) response elements shows that, in addition to the predominant direct repeat of the GGTCA motif with a 2-bp spacing, there are other functional COUP elements with variations in the GGTCA orientation and spacing. We systematically analyzed the binding of in vitro-synthesized COUP-TFs and showed that COUP-TF is capable of binding to oligonucleotides containing both direct repeats and palindromes and with different spacings of the GGTCA repeats. Subsequently, we analyzed four possible mechanisms proposed to explain how COUP-TF could bind to these spatial variations of the GGTCA repeat. We demonstrated that the functional DNA-binding form of COUP-TF is a dimer which requires two GGTCA half-sites to bind DNA. We demonstrated that the COUP-TF dimer undergoes a remarkable structural adaptation to accommodate binding to these spatial variants of the GGTCA repeats. A functional consequence of the promiscuous DNA binding of COUP-TF is its ability to down-regulate hormonal induction of target gene expression by other members of the steroid-thyroid hormone receptor superfamily such as the vitamin D3, thyroid hormone, and retinoic acid receptors. Our data indicate that COUP-TF may have an important role in hormonal regulation of gene expression by these receptors.

scholarly journals Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg.

1992 ◽  
Vol 89 (6) ◽  
pp. 2321-2325 ◽  
Author(s):  
B. Blumberg ◽  
D. J. Mangelsdorf ◽  
J. A. Dyck ◽  
D. A. Bittner ◽  
R. M. Evans ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Single Cell ◽  
Retinoic Acid Receptors ◽  
Retinoid X Receptors ◽  
Xenopus Egg ◽  
X Receptors

scholarly journals Recent progress on the role and molecular mechanism of chicken ovalbumin upstream promoter-transcription factor II in cancer

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052091923
Author(s):  
Seong-Hoon Yun ◽  
Joo-In Park
Keyword(s):  
Transcription Factor ◽  
Recent Progress ◽  
Molecular Mechanisms ◽  
Orphan Receptor ◽  
Expression Of Genes ◽  
Factor Ii ◽  
Upstream Promoter ◽  
Cancer Types ◽  
Breast And Prostate Cancer ◽  
Chicken Ovalbumin

Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is an orphan receptor that regulates the expression of genes involved in development and homeostasis. COUP-TFII is also dysregulated in cancer, where it plays important roles in oncogenesis and malignant progression. Recent studies have also investigated altered microRNA-mediated regulation of COUP-TFII in cancer. Although many investigators have studied the expression and clinical significance of COUP-TFII in several cancer types, there remain many controversies regarding its role in these diseases. In this review, we will describe the functions and underlying molecular mechanisms of COUP-TFII in several cancers, especially colorectal, gastric, breast, and prostate cancer; additionally, we will briefly summarize what is known about microRNA-mediated regulation of COUP-TFII.

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