scholarly journals The ubiquitin ligase Deltex‐3L regulates endosomal sorting of the G protein‐coupled receptor CXCR4 (1066.18)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Justine Holleman ◽  
Adriano Marchese
Keyword(s):  
G Protein ◽  
Ubiquitin Ligase ◽  
G Protein Coupled Receptor ◽  
Endosomal Sorting ◽  
G Protein Coupled

scholarly journals The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein–coupled receptor CXCR4

2014 ◽  
Vol 25 (12) ◽  
pp. 1892-1904 ◽  
Author(s):  
Justine Holleman ◽  
Adriano Marchese
Keyword(s):  
G Protein ◽  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Lysosomal Degradation ◽  
G Protein Coupled Receptor ◽  
Interacting Protein ◽  
Endosomal Sorting ◽  
Early Endosomes ◽  
New Gene ◽  
G Protein Coupled

G protein–coupled receptor (GPCR) sorting into the degradative pathway is important for limiting the duration and magnitude of signaling. Agonist activation of the GPCR CXCR4 induces its rapid ubiquitination and sorting to lysosomes via the endosomal sorting complex required for transport (ESCRT) pathway. We recently reported that ESCRT-0 ubiquitination is linked to the efficiency with which CXCR4 is sorted for lysosomal degradation; however mechanistic insight is lacking. Here we define a novel role for the really interesting new gene–domain E3 ubiquitin ligase deltex-3-like (DTX3L) in regulating CXCR4 sorting from endosomes to lysosomes. We show that DTX3L localizes to early endosomes upon CXCR4 activation and interacts directly with and inhibits the activity of the E3 ubiquitin ligase atrophin-1 interacting protein 4. This serves to limit the extent to which ESCRT-0 is ubiquitinated and is able to sort CXCR4 for lysosomal degradation. Therefore we define a novel role for DTX3L in GPCR endosomal sorting and reveal an unprecedented link between two distinct E3 ubiquitin ligases to control the activity of the ESCRT machinery.

scholarly journals The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization

Glia ◽  
2015 ◽  
Vol 63 (12) ◽  
pp. 2327-2339 ◽  
Author(s):  
Marta Fumagalli ◽  
Elisabetta Bonfanti ◽  
Simona Daniele ◽  
Elisa Zappelli ◽  
Davide Lecca ◽  
...  
Keyword(s):  
G Protein ◽  
Ubiquitin Ligase ◽  
Receptor Desensitization ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals The E3 Ubiquitin Ligase AIP4 Mediates Ubiquitination and Sorting of the G Protein-Coupled Receptor CXCR4

2003 ◽  
Vol 5 (5) ◽  
pp. 709-722 ◽  
Author(s):  
Adriano Marchese ◽  
Camilla Raiborg ◽  
Francesca Santini ◽  
James H Keen ◽  
Harald Stenmark ◽  
...  
Keyword(s):  
G Protein ◽  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Targeted Ubiquitination and Degradation of G-Protein-Coupled Receptor Kinase 5 by the DDB1-CUL4 Ubiquitin Ligase Complex

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43997 ◽  
Author(s):  
Ziyan Wu ◽  
Yuejun Chen ◽  
Tong Yang ◽  
Qinqin Gao ◽  
Man Yuan ◽  
...  
Keyword(s):  
G Protein ◽  
Ubiquitin Ligase ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Ubiquitin Ligase Complex ◽  
G Protein Coupled

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled
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