scholarly journals Thymoquinone Inhibits Neurodegeneration and Enhances Neurogenesis in Kainic Acid‐induced Middle‐aged Wistar Rat Model of Temporal Lobe Epilepsy

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Sijam Brito ◽  
Narayana Kilarkaje ◽  
Muddanna Rao
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Kainic Acid ◽  
Temporal Lobe ◽  
Rat Model ◽  
Wistar Rat ◽  
Middle Aged

The systemic kainic acid rat model of temporal lobe epilepsy: Long-term EEG monitoring

2015 ◽  
Vol 1627 ◽  
pp. 1-11 ◽  
Author(s):  
B. Van Nieuwenhuyse ◽  
R. Raedt ◽  
M. Sprengers ◽  
I. Dauwe ◽  
S. Gadeyne ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Kainic Acid ◽  
Temporal Lobe ◽  
Rat Model ◽  
Eeg Monitoring

scholarly journals Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy

2020 ◽  
Vol 22 (5) ◽  
pp. 1197-1207 ◽  
Author(s):  
Maria Elisa Serrano ◽  
Mohamed Ali Bahri ◽  
Guillaume Becker ◽  
Alain Seret ◽  
Charlotte Germonpré ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Kainic Acid ◽  
Temporal Lobe ◽  
Rat Model ◽  
Chronic Phase ◽  
Male Rats ◽  
Saline Control ◽  
Control Group ◽  
Significant Group

Abstract Purpose The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. Procedures Twenty Sprague Dawley male rats were administered with multiple systemic doses of saline (control group, n = 5) or kainic acid (5 mg/kg/injection, epileptic group, n = 15). Both groups were scanned at the four phases of TLE (early, latent, transition, and chronic phase) with the [18F]UCB-H PET radiotracer and T2-structural magnetic resonance imaging. At the end of the scans (3 months post-status epilepticus), rats were monitored for 7 days with electroencephalography for the detection of spontaneous electrographic seizures. Finally, the immunofluorescence staining for SV2A expression was performed. Results Control rats presented a significant increase in [18F]UCB-H binding at the last two scans, compared with the first ones (p < 0.001). This increase existed but was lower in epileptic animals, producing significant group differences in all the phases of the disease (p < 0.028). Furthermore, the quantification of the SV2A expression in vivo with the [18F]UCB-H radiotracer or ex vivo with immunofluorescence led to equivalent results, with a positive correlation between both. Conclusions Even if further studies in humans are required, the ability to detect a progressive decrease in SV2A expression during the development of temporal lobe epilepsy supports the use of [18F]UCB-H as a useful tool to differentiate, in vivo, between healthy and epileptic animals along with the development of the epileptic disease.

scholarly journals Hippocampal DBS affects disease development in the kainic acid rat model for temporal lobe epilepsy

2014 ◽  
Vol 8 ◽  
Author(s):  
Van Nieuwenhuyse Bregt ◽  
Raedt Robrecht ◽  
Sprengers Mathieu ◽  
Dauwe Ine ◽  
Gadeyne Stefanie ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Kainic Acid ◽  
Temporal Lobe ◽  
Rat Model ◽  
Disease Development

Up-regulated ephrinB3/EphB3 expression in intractable temporal lobe epilepsy patients and pilocarpine induced experimental epilepsy rat model

2016 ◽  
Vol 1639 ◽  
pp. 1-12 ◽  
Author(s):  
Hao Huang ◽  
Ruohan Li ◽  
Jinxian Yuan ◽  
Xin Zhou ◽  
Xi Liu ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
Experimental Epilepsy

scholarly journals A Macaque Model of Mesial Temporal Lobe Epilepsy Induced by Unilateral Intrahippocampal Injection of Kainic Acid

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72336 ◽  
Author(s):  
Ning Chen ◽  
Chong Liu ◽  
Na Yan ◽  
Wei Hu ◽  
Jian-guo Zhang ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Kainic Acid ◽  
Temporal Lobe ◽  
Mesial Temporal Lobe Epilepsy ◽  
Macaque Model ◽  
Intrahippocampal Injection ◽  
Mesial Temporal Lobe

Neuroregenerative Gene Therapy to Treat Temporal Lobe Epilepsy in a Rat Model

2021 ◽  
pp. 102198
Author(s):  
Jiajun Zheng ◽  
Tingjie Li ◽  
Shuang Qi ◽  
Bing Qin ◽  
Jiandong Yu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model
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