Serum and synovial fluid proteins in rheumatoid arthritis and degenerative joint diseases

Background: Analysis of synovial uid has been recommended as a routine procedure to assist in the diagnosis of arthritis. Arthritis can be either a monoarticular or polyarticular lesion leading to morbidity, affecting all ages . Aim of the study: To study synovial uid analysis in the diagnosis of joint diseases in a teaching hospital. Materials and methods: Prospective study was done on synovial uid samples over a period of two years at the Department of Pathology. ACS medical college ,Chennai for duration of 6 months ie, from February 2021 to August 2021. Results: Majority of the cases were osteoarthritis constituting 33.3 % .Rheumatoid arthritis constituted 20%..Chronic nonspecic synovitis were noted in 30% cases .01 case of Traumatic arthritis and 02 cases of Tubercular arthritis were noted. Conclusion: Synovial uid analysis will give us an idea about the differential diagnosis of joint diseases. Synovial uid aspiration should be done for the analysis and also used as a treatment procedure of synovial inammation.

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Unilateral knee effusion in an elderly patient: an unusual presentation of rheumatoid arthritis

Journal of Primary Health Care ◽

10.1071/hc20035 ◽

2020 ◽

Vol 12 (4) ◽

pp. 391

Author(s):

Morteza Khodaee ◽

Lindsay Ogle ◽

Cleveland Piggott

Keyword(s):

Rheumatoid Arthritis ◽

Geriatric Patients ◽

Plain Radiography ◽

Joint Diseases ◽

Advanced Imaging ◽

Presenting Symptoms ◽

Blood Tests ◽

Knee Effusion ◽

Common Causes ◽

Degenerative Joint Diseases

ABSTRACT Unilateral atraumatic knee effusion is a relatively common presenting complaint among geriatric patients in primary care and musculoskeletal speciality clinics. Gout, pseudogout, degenerative joint diseases and reactive arthritis are the most common causes of the atraumatic knee effusions. Rheumatoid arthritis very rarely presents as arthritis of one or two large joints. Arthrocentesis, plain radiography and screening blood tests should be performed to help narrow the differential diagnosis. In some cases, advanced imaging modalities such as MRI may be indicated. This study reports a case of rheumatoid arthritis in a 75-year-old gentleman with oligoarthropathy of two large joints as the presenting symptoms.

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Sulfated Hyaluronan coating of polyurethanebased implant materials

Current Directions in Biomedical Engineering ◽

10.1515/cdbme-2020-3115 ◽

2020 ◽

Vol 6 (3) ◽

pp. 446-449

Author(s):

Ralf Kemkemer ◽

Kiriaki Athanasopulu ◽

Dimitra Caltzidou ◽

Asuka Sekishita ◽

Larysa Kutuzova ◽

...

Keyword(s):

Hyaluronic Acid ◽

Synovial Fluid ◽

Joint Diseases ◽

Friction Forces ◽

Implant Materials ◽

Polycarbonate Urethane ◽

Coating Method ◽

Acid Coating ◽

Degenerative Joint Diseases

AbstractThermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubberlike properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.

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