ELEVATED PLASMA LEVELS OF LAUDANOSINE ARE ASSOCIATED WITH HIGH PLASMA CONCENTRATIONS OF NOREPINEPHRINE DURING ORTHOTOPIC LIVER TRANSPLANTATION IN PIGS

1988 ◽  
Vol 69 (3A) ◽  
pp. A484-A484
Author(s):  
J. F. Pittet ◽  
E. Tassonyi ◽  
C. Schopfer ◽  
D. R. Morel ◽  
M. Fahti ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
High Plasma ◽  
Elevated Plasma

scholarly journals Effects of Endothelin-1 on Hepatic Blood Flow

HPB Surgery ◽  
1996 ◽  
Vol 9 (3) ◽  
pp. 153-159 ◽  
Author(s):  
Kjetil Unneberg ◽  
Marianne Mjaaland ◽  
Elin Helseth ◽  
Arthur Revhaug
Keyword(s):  
Liver Transplantation ◽  
Blood Flow ◽  
Portal Vein ◽  
Plasma Concentrations ◽  
Hepatic Clearance ◽  
Elevated Plasma ◽  
Central Venous ◽  
Portal Vein Pressure ◽  
Portal Vein Flow ◽  
Endothelin 1

Endothelin-1 belongs to a family of potent vasoconstrictors, recently isolated from endothelial cells. Endothelin-1 has a variety of hepatic effects and hepatic clearance from the circulation is important. Elevated plasma concentrations of Endothelin-1 are found after orthotopic liver transplantation and in cirrhosis with ascites.This study in piglets on hepatic bloodflow was designed to compare differences in effects between central venous and intraportal injection of endothelin-1, and to evaluate effects of repeated injections. Central venous injection of endothelin-1 caused a larger reduction in portal vein flow, while intraportal injection caused a larger increase in portal vein pressure. Repeated injections resulted in a reduction in portal vein flow and an increase in portal vein vascular resistance.

scholarly journals Elevated Plasma Levels of Cell‐Free DNA During Liver Transplantation Are Associated With Activation of Coagulation

2020 ◽  
Vol 26 (4) ◽  
pp. 602-603
Author(s):  
Osamu Yoshino ◽  
Vijayaragavan Muralidharan ◽  
Alexander Dobrovic ◽  
Su Kah Goh
Keyword(s):  
Liver Transplantation ◽  
Plasma Levels ◽  
Elevated Plasma ◽  
Cell Free Dna ◽  
Free Dna

High Plasma Concentration of Factor VIIIc Is a Major Risk Factor for Venous Thromboembolism

2000 ◽  
Vol 83 (01) ◽  
pp. 5-9 ◽  
Author(s):  
Pieternella in 't Anker ◽  
Marianne Koopman ◽  
Pieter Reitsma ◽  
Martin Prins ◽  
Abraham van den Ende ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Plasma Levels ◽  
Family Study ◽  
High Plasma ◽  
Elevated Plasma ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Recurrent Venous Thromboembolism ◽  
Over Time

SummaryEstablished risk factors, including deficiencies of protein C, protein S or antithrombin and the factor V Leiden and prothrombin mutation, are present in about one third of unselected patients with venous thromboembolism. In addition to these inherited thrombophilic defects, elevated plasma levels of factor VIIIc have been suggested to be important in the pathogenesis of (recurrent) venous thromboembolism. The objective of this study was to assess the relevance of factor VIIIc plasma concentration in consecutive patients with venous thromboembolism.We studied the prevalence of elevated plasma levels of factor VIIIc in 65 patients with a proven single episode and in 60 matched patients with documented recurrent venous thromboembolism. The reference group consisted of 60 ageand sex-matched patients who were referred for suspected venous thromboembolism, which was refuted by objective testing and longterm clinical follow-up. To minimalize the influence of the acute phase, blood was obtained at least 6 months after the thromboembolic event and results were adjusted for fibrinogen and C-reactive protein. Factor VIIIc was re-determined several years after the first measurement in a subset of patients to evaluate the variability over time. To study a possible genetic cause, a family study was done.In the control, single and recurrent episode group, the prevalences of plasma levels of factor VIIIc above 175 IU/dl (90th percentile of controls) were 10% (95% CI: 4 to 21%), 19% (95% CI: 10 to 30%) and 33% (95% CI: 22 to 47%), respectively. For each 10 IU/dl increment of factor VIIIc, the risk for a single and recurrent episode of venous thrombosis increased by 10% (95% CI: 0.9 to 21%) and 24% (95% CI: 11 to 38%), respectively. Both low and high plasma levels of factor VIIIc were consistent over time (R = 0.80, p = 0.01). A family study indicated a high concordance for elevated factor VIIIc plasma concentrations among first degree family members. Adjustment for fibrinogen, C-reactive protein and known thrombophilic risk factors did not change the observed association of elevated factor VIIIc with thrombosis.Elevated plasma levels of factor VIIIc are a significant, prevalent, independent and dose-dependent risk factor for venous thromboembolism. It also predisposes to recurrent venous thromboembolism.

Release of Neopterin, PMN Elastase and Terminal Complement Complexes by Orthotopic Liver Transplantation with and without the Use of Veno-venous Bypass

Pteridines ◽  
1998 ◽  
Vol 9 (1) ◽  
pp. 1-7
Author(s):  
H. Tomasdottir ◽  
E. Rønholm ◽  
JP Bengtson ◽  
A. Bengtsson
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Plasma Concentrations ◽  
Venous Bypass ◽  
Pmn Elastase ◽  
Arterial Blood ◽  
Neopterin Concentration ◽  
Pmn Élastase ◽  
Terminal Complement Complexes ◽  
Terminal Complement

Summary Aim: The aim of the study was to determine whether orthotopic liver transplantation leads to the activation of macrophages, neutrophils and complement. Patients and methods: Twenty-four patients undergoing orthotopic liver transplantation were studied. 12 were operated on with and 12 without the use of a veno-venous bypass. Blood samples for neopterin, PMN elastase and terminal complement complex (SC5b-9) determinations were drawn preoperatively, 1 minute before perfusion of the grafted liver and 2-5 and 30-60 minutes after the start of perfusion of the grafted liver. Comparisons were made between patients with or withour a veno-venous bypass and with or without postreperfusion syndrome (PRS) . PRS was defined as hypotension with ≥30% reduction of systemic mean arterial blood pressure during at least 1 minute after reperfusion of the grafted liver. Results: Release of neopterin was observed 2-5 and 30-60 minutes after the start of perfusion of the grafted liver in patients operated upon with and without the use of a veno-venous bypass. There were no significant differences in neopterin concentration between patients developing PRS and those without circulatory instability. Increased PMN elastase and SC5b-9 concentrations (p<0.05) were found 2-5 and 30-60 minutes after the start of reperfusion in both patients operated upon with and without a veno-venous bypass. The plasma concentrations of neopterin, PMN elastase and SC5b-9 were higher in patients with PRS compared with those without (p<0.05, respectively). Comments: This study indicates that orthotopic liver transplantation leads to the activation of macrophages, neutrophils and the complement cascade. There is no major difference regarding the activation between patients operated upon with and without the use of a veno-venous bypass.

A883 DOSE REQUIREMENTS AND PLASMA LEVELS OF PIPECURONIUM DURING RENAL EXCLUSION AND ORTHOTOPIC LIVER TRANSPLANTATION IN PIGS

1990 ◽  
Vol 73 (3A) ◽  
pp. NA-NA
Author(s):  
J. F. Pittet ◽  
E. Tassonyi ◽  
C. Schopfer ◽  
D. R. Morel ◽  
G. Mentha ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Plasma Levels

RADIOIMMUNOASSAY FOR PORCINE PROLACTIN: PLASMA LEVELS DURING LACTATION, SUCKLING AND WEANING AND AFTER TRH ADMINISTRATION

1978 ◽  
Vol 88 (3) ◽  
pp. 653-667 ◽  
Author(s):  
A. A. J. van Landeghem ◽  
D. F. M. van de Wiel
Keyword(s):  
Plasma Levels ◽  
Solid Phase ◽  
Plasma Concentrations ◽  
High Plasma ◽  
Cross Reaction ◽  
Phase System ◽  
Detectable Amount ◽  
Thyrotrophin Releasing Hormone ◽  
Ovine Prolactin ◽  
Plasma Prl

ABSTRACT A sensitive heterologous radioimmunoassay for porcine prolactin (pPRL) has been developed. Anti-ovine prolactin antibody was raised in rabbits which allowed a final dilution of 1:500 000. The separation of free and antibody bound [125I]pPRL is based on the double antibody solid phase system. The assay is specific for pPRL. There is no cross-reaction with pLH, pFSH and pTSH; little cross-reaction (1.35 %) was found with pGH. The smallest detectable amount was 0.08 ng per tube. During lactation high plasma levels are found with great fluctuations. After weaning the plasma PRL levels fall to basal levels within a few hours. After thyrotrophin-releasing hormone (TRH) administration plasma concentrations increase within a few minutes.

Plasma Concentrations of Laudanosine, but Not of Atracurium, Are Increased during the Anhepatic Phase of Orthotopic Liver Transplantation in Pigs

1990 ◽  
Vol 72 (1) ◽  
pp. 145-152 ◽  
Author(s):  
Jean-François Pittet ◽  
Edömer Tassonyi ◽  
Corinne Schopfer ◽  
Denis R. Morel ◽  
Gilles Mentha ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Plasma Concentrations ◽  
Anhepatic Phase

Is 3α-androstanediol a marker of peripheral hirsutism?

1982 ◽  
Vol 99 (2) ◽  
pp. 314-320 ◽  
Author(s):  
Vincenzo Toscano ◽  
Francesco Sciarra ◽  
Maria Vittoria Adamo ◽  
Elisa Petrangeli ◽  
Sonia Foli ◽  
...  
Keyword(s):  
Chromatographic Separation ◽  
Plasma Levels ◽  
Normal Values ◽  
Plasma Concentrations ◽  
High Plasma ◽  
The Other ◽  
Dehydroepiandrosterone Sulphate ◽  
Group I ◽  
Group Ii ◽  
Peripheral Origin

Abstract. The behaviour of 5α-reduced metabolites of testosterone, dihydrotestosterone1, 3α-androstanediol and 3β-androstanediol, was studied in 36 hirsute women: Group I: 24 patients with high plasma levels of testosterone, androstenedione and/or dehydroepiandrosterone sulphate and Group II: 12 patients with normal plasma concentrations of these steroids. Testosterone and its 5α-reduced metabolites were determined by radioimmunoassay after chromatographic separation on celite 535 microcolumns. Plasma 3α-androstanediol was found to be elevated both in Group I (26.9 ± 10.8 sd ng/100 ml) and in Group II patients (23.2 ± 10.5 sd ng/100 ml). 3β-Androstanediol and dihydrotestosterone, on the contrary, were elevated in only a few cases: in 6 cases in Group I and in 2 and in 1 case, respectively, in Group II. The finding of high plasma 3α-androstanediol levels in hirsute women, with normal values of the other androgens, may be an index of hirsutism of peripheral origin, since this steroid is produced almost exclusively in the extraglandular compartment.

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