High Plasma Concentration of Factor VIIIc Is a Major Risk Factor for Venous Thromboembolism

SummaryEstablished risk factors, including deficiencies of protein C, protein S or antithrombin and the factor V Leiden and prothrombin mutation, are present in about one third of unselected patients with venous thromboembolism. In addition to these inherited thrombophilic defects, elevated plasma levels of factor VIIIc have been suggested to be important in the pathogenesis of (recurrent) venous thromboembolism. The objective of this study was to assess the relevance of factor VIIIc plasma concentration in consecutive patients with venous thromboembolism.We studied the prevalence of elevated plasma levels of factor VIIIc in 65 patients with a proven single episode and in 60 matched patients with documented recurrent venous thromboembolism. The reference group consisted of 60 ageand sex-matched patients who were referred for suspected venous thromboembolism, which was refuted by objective testing and longterm clinical follow-up. To minimalize the influence of the acute phase, blood was obtained at least 6 months after the thromboembolic event and results were adjusted for fibrinogen and C-reactive protein. Factor VIIIc was re-determined several years after the first measurement in a subset of patients to evaluate the variability over time. To study a possible genetic cause, a family study was done.In the control, single and recurrent episode group, the prevalences of plasma levels of factor VIIIc above 175 IU/dl (90th percentile of controls) were 10% (95% CI: 4 to 21%), 19% (95% CI: 10 to 30%) and 33% (95% CI: 22 to 47%), respectively. For each 10 IU/dl increment of factor VIIIc, the risk for a single and recurrent episode of venous thrombosis increased by 10% (95% CI: 0.9 to 21%) and 24% (95% CI: 11 to 38%), respectively. Both low and high plasma levels of factor VIIIc were consistent over time (R = 0.80, p = 0.01). A family study indicated a high concordance for elevated factor VIIIc plasma concentrations among first degree family members. Adjustment for fibrinogen, C-reactive protein and known thrombophilic risk factors did not change the observed association of elevated factor VIIIc with thrombosis.Elevated plasma levels of factor VIIIc are a significant, prevalent, independent and dose-dependent risk factor for venous thromboembolism. It also predisposes to recurrent venous thromboembolism.

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Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study

Physiological Genomics ◽

10.1152/physiolgenomics.00054.2005 ◽

2006 ◽

Vol 27 (2) ◽

pp. 103-107 ◽

Cited By ~ 10

Author(s):

Timo A. Lakka ◽

Tuomo Rankinen ◽

Treva Rice ◽

Arthur S. Leon ◽

D. C. Rao ◽

...

Keyword(s):

Plasma Levels ◽

Family Study ◽

Inflammatory Diseases ◽

Low Grade ◽

C Reactive Protein ◽

Lod Score ◽

Chronic Inflammatory Diseases ◽

Reactive Protein ◽

A Genome ◽

Chromosome 20Q13

C-reactive protein (CRP) is a sensitive marker of systemic low-grade inflammation. Increased plasma levels of CRP predict the risk of cardiovascular and metabolic diseases. Although genetic factors account for 30–40% of individual differences in plasma CRP levels, genomic regions contributing to CRP levels remain unknown. We performed a genome-wide linkage scan for plasma CRP levels in healthy whites from the HERITAGE Family Study. CRP was measured with a high-sensitivity assay. Multipoint linkage analyses were performed in 280 sibling pairs with 654 markers using regression and variance components-based methods. Data were adjusted for independent correlates of plasma CRP. We showed the strongest evidence of linkage for plasma CRP levels on chromosome 20q13. Markers which gave suggestive linkages in this region were D20S52 [logarithm of odds (LOD) score 3.18, P = 0.00006], D20S857 (LOD score 2.87, P = 0.00014), D20S869 (LOD score 2.75, P = 0.0002), D20S480 (LOD score 2.59, P = 0.0003), D20S501 (LOD score 2.55, P = 0.0003), D20S840 (LOD score 2.18, P = 0.0008), and D20S876 (LOD score 2.07, P = 0.001). We also detected suggestive linkage on chromosome 5p13 for marker D5S1470 (LOD score 2.23, P = 0.0007). Chromosome 20q13 may contribute to plasma CRP levels in healthy whites. This region contains genes that are important in the inflammatory process and may play a role in the development of chronic inflammatory diseases. The present findings may be useful in the ongoing effort to search for genes contributing to inflammation and to identify individuals at an increased risk of chronic inflammatory diseases.

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High Plasma Levels of Factor VIII and the Risk of Recurrent Venous Thromboembolism

New England Journal of Medicine ◽

10.1056/nejm200008173430702 ◽

2000 ◽

Vol 343 (7) ◽

pp. 457-462 ◽

Cited By ~ 472

Author(s):

Paul A. Kyrle ◽

Erich Minar ◽

Mirko Hirschl ◽

Christine Bialonczyk ◽

Milena Stain ◽

...

Keyword(s):

Venous Thromboembolism ◽

Factor Viii ◽

Plasma Levels ◽

High Plasma ◽

Recurrent Venous Thromboembolism

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174. Elevated plasma levels of C-reactive protein are predictors of late restenosis after coronary angioplasty

Fibrinolysis and Proteolysis ◽

10.1016/s0268-9499(96)80750-8 ◽

1996 ◽

Vol 10 ◽

pp. 54

Author(s):

S. Hornykewycz ◽

M. Mehrabi ◽

M. Gwechenberger ◽

K.M. Kostner ◽

G. Zorn ◽

...

Keyword(s):

Coronary Angioplasty ◽

Plasma Levels ◽

Elevated Plasma ◽

C Reactive Protein ◽

Reactive Protein ◽

Late Restenosis

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Elevated Plasma Levels of B-Type Natriuretic Peptide but Not C-Reactive Protein Are Associated With Higher Red Cell Distribution Width in Patients With Coronary Artery Disease

International Heart Journal ◽

10.1536/ihj.50.301 ◽

2009 ◽

Vol 50 (3) ◽

pp. 301-312 ◽

Cited By ~ 59

Author(s):

Hidekatsu Fukuta ◽

Nobuyuki Ohte ◽

Seiji Mukai ◽

Tomoaki Saeki ◽

Kaoru Asada ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Plasma Levels ◽

Red Cell ◽

Cell Distribution ◽

Elevated Plasma ◽

C Reactive Protein ◽

Distribution Width ◽

Reactive Protein ◽

Artery Disease

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Elevated plasma fibronectin levels associated with venous thromboembolism

Thrombosis and Haemostasis ◽

10.1160/th08-02-0078 ◽

2008 ◽

Vol 100 (08) ◽

pp. 224-228 ◽

Cited By ~ 7

Author(s):

Natalie M. Pecheniuk ◽

Darlene J. Elias ◽

Hiroshi Deguchi ◽

Patricia M. Averell ◽

John H. Griffin

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Factor V Leiden ◽

Arterial Disease ◽

High Plasma ◽

Factor V ◽

Plasma Fibronectin ◽

Elevated Plasma ◽

Before And After ◽

The Difference

SummaryElevated plasma fibronectin levels occur in various clinical states including arterial disease. Increasing evidence suggests that atherothrombosis and venous thromboembolism (VTE) share common risk factors. To assess the hypothesis that high plasma fibronectin levels are associated with VTE, we compared plasma fibronectin levels in the Scripps Venous Thrombosis Registry for 113VTE cases vs. age and sex matched controls. VTE cases had significantly higher mean fibronectin concentration compared to controls (127% vs. 103%, p<0.0001); the difference was greater for idiopathic VTE cases compared to secondary VTE cases (133% vs. 120%, respectively). Using a cut-off of >90% of the control values, the odds ratio (OR) for association of VTE for fibronectin plasma levels above the 90th percentile were 9.37 (95% CI 2.73–32.2; p<0.001) and this OR remained significant after adjustment for sex, age, body mass index (BMI), factor V Leiden and prothrombin nt20210A (OR 7.60,95% CI 2.14–27.0; p=0.002). In particular, the OR was statistically significant for idiopathic VTE before and after these statistical adjustments. For the total male cohort, the OR was significant before and after statistical adjustments and was not significant for the total female cohort. In summary, our results suggest that elevated plasma fibronectin levels are associated with VTE especially in males, and extend the potential association between biomarkers and risk factors for arterial atherothrombosis and VTE.

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405 PLASMA LEVELS OF C-REACTIVE PROTEIN IN OVERWEIGHT CHILDREN AND ADOLESCENTS WITH CARDIAC-RELATED FAMILIAL RISK FACTORS.:

Journal of Investigative Medicine ◽

10.2310/6650.2005.x0004.404 ◽

2006 ◽

Vol 54 (1) ◽

pp. S149.3-S149

Author(s):

W. N. Evans ◽

G. A. Mayman ◽

R. J. Acherman ◽

K. A. Cass ◽

K. T. Kip ◽

...

Keyword(s):

Risk Factors ◽

Children And Adolescents ◽

Plasma Levels ◽

Familial Risk ◽

Overweight Children ◽

C Reactive Protein ◽

Reactive Protein ◽

Familial Risk Factors

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Plasma Trans Fatty Acid Levels, Cardiovascular Risk Factors and Lifestyle: Results from the Akershus Cardiac Examination 1950 Study

Nutrients ◽

10.3390/nu12051419 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1419

Author(s):

Anupam Chandra ◽

Magnus Nakrem Lyngbakken ◽

Ivar Anders Eide ◽

Helge Røsjø ◽

Thea Vigen ◽

...

Keyword(s):

Risk Factors ◽

Fatty Acids ◽

Trans Fatty Acids ◽

High Plasma ◽

Cross Sectional Study ◽

C Reactive Protein ◽

Serum Triglycerides ◽

Cross Sectional ◽

Reactive Protein ◽

The Relationship

Intake of industrially produced trans fatty acids (iTFAs) has previously been associated with dyslipidemia, insulin resistance, hypertension and inflammation, as well as increased cardiovascular (CV) morbidity and mortality. iTFA intake declined in Norway after the introduction of legislative bans against iTFA consumption. However, the relationship between the current iTFA intake and CV health is unclear. The aim of the present study was to investigate the association between current iTFA intake, reflected by plasma iTFA levels, and established CV risk factors. We also examined the associations between plasma ruminant TFA levels and CV risk factors. In this cross-sectional study, we included 3706 participants from a Norwegian general population, born in 1950 and residing in Akershus County, Norway. The statistical method was multivariable linear regression. Plasma iTFA levels were inversely associated with serum triglycerides (p < 0.001), fasting plasma glucose (p < 0.001), body mass index (p < 0.001), systolic and diastolic blood pressure (p = 0.001 and p = 0.03) and C-reactive protein (p = 0.001). Furthermore, high plasma iTFA levels were associated with higher education and less smoking and alcohol consumption. We found that plasma ruminant trans fatty acids (rTFA) levels were favorably associated with CV risk factors. Furthermore, plasma iTFA levels were inversely associated with CV risk factors. However, our results might have been driven by lifestyle factors. Overall, our findings suggest that the current low intake of iTFAs in Norway does not constitute a threat to CV health.

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