Development of visual function in preterm infants: Implications for early intervention

1993 ◽  
Vol 6 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Penny Glass
2020 ◽  
Vol 8 ◽  
Author(s):  
Camilla Fontana ◽  
Agnese De Carli ◽  
Daniela Ricci ◽  
Francesca Dessimone ◽  
Sofia Passera ◽  
...  

2019 ◽  
Author(s):  
Camilla Fontana ◽  
Federica Marasca ◽  
Livia Provitera ◽  
Sara Mancinelli ◽  
Nicola Pesenti ◽  
...  

ABSTRACTBackgroundEarly life adversity exposure impacts preterm infants’ neurodevelopment and early intervention protocols may modulate neurodevelopmental outcomes.Neuronal genomes are plastic in response to environment and mobile genetic elements, including LINE-1 (L1), are source of brain genomic mosaicism. Maternal care during early life regulates L1 methylation and copy number variations (CNVs) in mice. Here, we sought to identify the effects of maternal care and positive multisensory stimulation (Early Intervention) on L1 methylation and neurodevelopment in preterm infants.MethodsVery preterm infants were randomized to receive Standard Care or Early Intervention. L1 methylation was measured at birth and at hospital discharge. At 12 months infants’ neurodevelopment was evaluated with the Griffiths Scales. L1 methylation and CNVs were measured in mouse brain areas at embryonic and postnatal stages.ResultsWe demonstrated that L1 is hypomethylated in preterm versus term infants at birth. Early Intervention contributes to restore L1 methylation and positively modulates neurodevelopment. We showed that L1 methylation is developmentally-regulated in mice, decreasing in early postnatal life stages, which turns into an increased L1 CNVs specifically in hippocampus and cortex.ConclusionsHere we demonstrated that L1 dynamics can be modulated by Early Intervention, in parallel with ameliorated neurodevelopmental outcomes. We further identified a specific developmental window of the fetal mouse brain, sensitive to early life experience, in which L1 dynamics are fine-tuned contributing to shape the brain genomic landscape.Trail RegistrationclinicalTrial.gov (NCT02983513)FundingItalian Ministry of Health (RC 780/03 2017), University of Milan (DISCCO 2015) and INGM internal funding.


PEDIATRICS ◽  
2011 ◽  
Vol 129 (1) ◽  
pp. e9-e16 ◽  
Author(s):  
S. M. Nordhov ◽  
J. A. Ronning ◽  
S. E. Ulvund ◽  
L. B. Dahl ◽  
P. I. Kaaresen

2012 ◽  
Vol 29 (09) ◽  
pp. 747-754 ◽  
Author(s):  
Nicolaos Kozeis ◽  
Maria Mavromichali ◽  
Vasiliki Soubasi-Griva ◽  
Eleni Agakidou ◽  
Dimitris Zafiriou ◽  
...  

PEDIATRICS ◽  
1980 ◽  
Vol 66 (1) ◽  
pp. 83-90
Author(s):  
Susan A. Leib ◽  
D. Gary Benfield ◽  
John Guidubaldi

To test the hypothesis that early intervention can enhance the development of high-risk preterm infants, a prescribed multimodal sensory enrichment program, within a regional neonatal intensive care unit, was designed and implemented. Twenty-eight appropriate-for-gestational age infants with birth weights between 1,200 and 1,800 gm were selected for study. To prevent control group contamination by the enrichment procedure, the first 14 infants were designated as the control group, and the next 14 as the treatment group. Treated infants had significantly higher developmental status than control infants, as measured by the Bayley Scales of Infant Development, at six months past the maternal expected date of confinement (F = 14.98, P < .001, and F = 16.46, P < .001 for the mental and motor scales, respectively). Mean infant weight gain per day and mean total weight gain during the hospitalization were not significantly different for the two groups although the treatment group received significantly less calories per kilogram per day than the control group (F = 9.02 P < .006). Our data suggest that a prescribed intervention program for high-risk preterm infants appears to enhance the quality of development as measured at six months past the expected date of confinement. Further studies are necessary to determine the long-term value of early intervention and the apparent ability of infants receiving an enrichment program to utilize calories more efficiently than control infants.


2018 ◽  
Vol 121 ◽  
pp. 15-20 ◽  
Author(s):  
Camilla Fontana ◽  
Camilla Menis ◽  
Nicola Pesenti ◽  
Sofia Passera ◽  
Nadia Liotto ◽  
...  

2010 ◽  
Vol 156 (4) ◽  
pp. 550-555 ◽  
Author(s):  
Daniela Ricci ◽  
Laura Cesarini ◽  
Francesca Gallini ◽  
Francesca Serrao ◽  
Daniela Leone ◽  
...  

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