Association between family history of affective disorder and the depressive syndrome of Alzheimer??s disease

1991 ◽  
Vol 5 (1) ◽  
pp. 47
Author(s):  
G D Pearlson ◽  
C A Ross ◽  
W D Lohr ◽  
BW Rovner ◽  
G A Chase ◽  
...  
Keyword(s):  
Family History ◽  
Affective Disorder ◽  
Depressive Syndrome ◽  
History Of

Everyday creativity and bipolar and unipolar affective disorder: preliminary study of personal and family history

1992 ◽  
Vol 7 (2) ◽  
pp. 49-52 ◽  
Author(s):  
R Richards ◽  
DK Kinney ◽  
H Daniels ◽  
K Linkins
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Affective Disorder ◽  
Affective Disorders ◽  
Bipolar Disorders ◽  
Data Support ◽  
History Of ◽  
Preliminary Study ◽  
Everyday Creativity ◽  
Underlying Mechanisms

SummaryPreliminary new data support the enhancement of ‘everyday’ creativity among those persons with bipolar disorders who manifest milder rather than more severe mood elevations, and among certain individuals who are likely to carry bipolar liability but themselves show no clinical mood elevations – in this case, unipolar depressives with a family history of bipolar disorder, when compared with depressives lacking this history. Creativity was assessed using the lifetime creativity scales (Richards el al, 1988). Underlying mechanisms may be multifactorial and complex. Results suggest that both personal and family history should be considered when making predictions concerning creativity and affective disorders.

Pre-Pubertal Depressive Stupor: A Case Report

1988 ◽  
Vol 153 (5) ◽  
pp. 689-692 ◽  
Author(s):  
J. C. Powell ◽  
W. R. Silveira ◽  
R. Lindsay
Keyword(s):  
Case Report ◽  
Family History ◽  
Affective Disorder ◽  
Dexamethasone Suppression Test ◽  
Clinical State ◽  
Affective Illness ◽  
History Of ◽  
Suppression Test ◽  
Dexamethasone Suppression ◽  
Maternal Side

A case of childhood affective disorder with episodes of depressive stupor in a 13-year-old pre-pubertal boy is described. Changes in the patient's clinical state were accompanied by changes in the dexamethasone suppression test. A family history of affective illness on the maternal side, with phenomenological similarities, is noted.

The Expression of Schizophrenia, Affective Disorder and Vulnerability to Tardive Dyskinesia in an Extensive Pedigree

1988 ◽  
Vol 153 (3) ◽  
pp. 376-381 ◽  
Author(s):  
John L. Waddington ◽  
Hanafy A. Youssef
Keyword(s):  
Family History ◽  
Tardive Dyskinesia ◽  
Movement Disorder ◽  
Affective Disorder ◽  
Psychiatric Illness ◽  
Late Onset ◽  
Psychiatric Morbidity ◽  
Neuroleptic Treatment ◽  
History Of

The demography, psychiatric morbidity, and motor consequences of long-term neuroleptic treatment in the 14 children born to a father with a family history of chronic psychiatric illness and a mother with a late-onset affective disorder resulting in suicide are documented. Twelve siblings lived to adulthood, nine of whom were admitted to a psychiatric hospital in their second or third decade, and required continuous in-patient care; five remaining in hospital, with long-term exposure to neuroleptics, had chroniC., deteriorating, schizophrenic illness and emergence of movement disorder. Two siblings showed no evidence of psychosis but developed a late-onset affective disorder. The implications for the issues of homotypia, vulnerability to involuntary movements, and interaction with affective disorder are discussed.

Mania and Down's Syndrome

1993 ◽  
Vol 162 (6) ◽  
pp. 739-743 ◽  
Author(s):  
Sally-Ann Cooper ◽  
Richard A. Collacott
Keyword(s):  
Learning Disabilities ◽  
Family History ◽  
Affective Disorder ◽  
Clinical Features ◽  
Case Reports ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Atypical Presentation ◽  
Rapid Cycling ◽  
History Of

Until recently, it was considered that Down's syndrome precluded a diagnosis of mania, or gave rise to an atypical presentation. There have been seven case reports of mania in people with Down's syndrome and all these cases are reviewed. The clinical features of mania are noted to be similar to those previously described in individuals with learning disabilities due to other causes. However, all reported cases are male and none has a family history of affective disorder. In two of the seven men reported, the illness followed a rapid cycling pattern. Hypothyroidism and monoamine biochemistry in people with Down's syndrome are discussed in the context of these atypical features.

Lithium in a Case of Severe Anorexia Nervosa

1982 ◽  
Vol 140 (5) ◽  
pp. 526-528 ◽  
Author(s):  
G. S. Stein ◽  
S. Hartshorn ◽  
J. Jones ◽  
D. Steinberg
Keyword(s):  
Anorexia Nervosa ◽  
Depressive Symptoms ◽  
Family History ◽  
Affective Disorder ◽  
Complex Relationship ◽  
Psychological Treatments ◽  
Treatment Of Depression ◽  
History Of

Anorexia nervosa may sometimes be resistant to all forms of therapy, with cases running through a gamut of somatic and psychological treatments. One possible explanation for this may be that the illness is of heterogeneous aetiology (Kay and Leigh, 1938; King, 1963; Feighner et al, 1972), although others regard anorexia as a single condition that tends to breed true though having protean manifestations (Russell, 1970; Crisp et al, 1980). In most of the larger series of cases, a proportion have depressive symptoms both during the illness (Dally, 1969; Theander, 1970; Crisp et al, 1980) and some years later (Morgan and Russell, 1975; Hsu et al, 1979), and a family history of affective disorder is also commonly reported (Dally, 1969; Theander, 1970; Morgan and Russell, 1975). Cantwell et al (1977) have reviewed the complex relationship between depression and anorexia nervosa and have suggested that some of the remedies used in the treatment of depression merit further exploration in the management of anorexia nervosa. We report here a patient who was in hospital for over four years and in whose eventual improvement lithium may have played an important role.

The phenomenology and diagnosis of psychiatric illness in people with Prader–Willi syndrome

2008 ◽  
Vol 38 (10) ◽  
pp. 1505-1514 ◽  
Author(s):  
S. Soni ◽  
J. Whittington ◽  
A. J. Holland ◽  
T. Webb ◽  
E. N. Maina ◽  
...  
Keyword(s):  
Family History ◽  
Affective Disorder ◽  
Psychiatric Illness ◽  
Uniparental Disomy ◽  
Psychotic Symptoms ◽  
Chromosome 15 ◽  
Prader Willi Syndrome ◽  
Psychotic Illness ◽  
Genetic Subtype ◽  
History Of

BackgroundPsychotic illness is strongly associated with the maternal uniparental disomy (mUPD) genetic subtype of Prader–Willi syndrome (PWS), but not the deletion subtype (delPWS). This study investigates the clinical features of psychiatric illness associated with PWS. We consider possible genetic and other mechanisms that may be responsible for the development of psychotic illness, predominantly in those with mUPD.MethodThe study sample comprised 119 individuals with genetically confirmed PWS, of whom 46 had a history of psychiatric illness. A detailed clinical and family psychiatric history was obtained from these 46 using the PAS-ADD, OPCRIT, Family History and Life Events Questionnaires.ResultsIndividuals with mUPD had a higher rate of psychiatric illness than those with delPWS (22/34 v. 24/85, p<0.001). The profile of psychiatric illness in both genetic subtypes resembled an atypical affective disorder with or without psychotic symptoms. Those with delPWS were more likely to have developed a non-psychotic depressive illness (p=0.005) and those with mUPD a bipolar disorder with psychotic symptoms (p=0.00005). Individuals with delPWS and psychotic illness had an increased family history of affective disorder. This was confined exclusively to their mothers.ConclusionsPsychiatric illness in PWS is predominately affective with atypical features. The prevalence and possibly the severity of illness are greater in those with mUPD. We present a ‘two-hit’ hypothesis, involving imprinted genes on chromosome 15, for the development of affective psychosis in people with PWS, regardless of genetic subtype.

The Occurrence of Depression Following Mania

1989 ◽  
Vol 154 (5) ◽  
pp. 705-708 ◽  
Author(s):  
C. P. Lucas ◽  
J. C. Rigby ◽  
S. B. Lucas
Keyword(s):  
Discriminant Analysis ◽  
Family History ◽  
Retrospective Analysis ◽  
Affective Disorder ◽  
Past History ◽  
Premorbid Personality ◽  
History Of ◽  
History Of Depression

In a retrospective analysis of 100 cases of mania (1981–1985), the incidence of subsequent depression was found to be 30%. Its occurrence was significantly associated with three factors: cyclothymic premorbid personality, family history of affective disorder, and past history of depression. By discriminant analysis, outcome could be predicted successfully in 81% of cases.

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