Antitumor Activity of Interleukin-18 on Mouse Glioma Cells

2000 ◽  
Vol 23 (2) ◽  
pp. 184-189 ◽  
Author(s):  
Tetsuro Kikuchi ◽  
Yasuharu Akasaki ◽  
Tatsuhiro Joki ◽  
Toshiaki Abe ◽  
Masashi Kurimoto ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Glioma Cells ◽  
Interleukin 18 ◽  
Mouse Glioma

Antitumor Activity of Killer Cells Stimulated with Both Interleukin-2 and Interleukin-12 on Mouse Glioma Cells

1999 ◽  
Vol 22 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Tetsuro Kikuchi ◽  
Tatsuhiro Joki ◽  
Toshiaki Abe ◽  
Tsuneya Ohno
Keyword(s):  
Antitumor Activity ◽  
Interleukin 2 ◽  
Glioma Cells ◽  
Interleukin 12 ◽  
Killer Cells ◽  
Mouse Glioma

scholarly journals Hyperthermia studies using inductive and ultrasound methods on E. coli bacteria and mouse glioma cells

2017 ◽  
Vol 238 (1) ◽  
Author(s):  
A. Cabral–Prieto ◽  
R. López-Callejas ◽  
B. G. Rodríguez-Méndez ◽  
C. L. Santos-Cuevas ◽  
J. Celis-Almazán ◽  
...  
Keyword(s):  
Glioma Cells ◽  
E Coli ◽  
Mouse Glioma

Effects of methylmercury on mitotic mouse glioma cells

1978 ◽  
Vol 17 (3) ◽  
pp. 453-471 ◽  
Author(s):  
Kyoko Miura ◽  
Keiko Suzuki ◽  
Nobumasa Imura
Keyword(s):  
Glioma Cells ◽  
Mouse Glioma

scholarly journals SLIT2-ROBO signaling in tumor-associated microglia/macrophages drives glioblastoma immunosuppression and vascular dysmorphia

2021 ◽  
Author(s):  
Luiz Henrique Geraldo ◽  
Yunling Xu ◽  
Laurent Jacob ◽  
Laurence Pibouin Fragner ◽  
Rohit Rao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Microenvironment ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Glioma Cells ◽  
Tumor Vessel ◽  
Poor Survival ◽  
Macrophage Chemotaxis ◽  
Migration Of Cells ◽  
Mouse Glioma

AbstractSLIT2 is a secreted polypeptide that guides migration of cells expressing ROBO1&2 receptors. Herein, we investigated SLIT2/ROBO signaling effects in gliomas. In patients with glioblastoma (GBM), SLIT2 expression increased with malignant progression and correlated with poor survival and immunosuppression. Knockdown of SLIT2 in mouse glioma cells and patient derived GBM xenografts reduced tumor growth and synergized with immunotherapy to prolong survival. Tumor cell SLIT2 knockdown inhibited macrophage invasion and promoted a cytotoxic gene expression profile, which improved tumor vessel function and enhanced efficacy of chemotherapy and immunotherapy. Mechanistically, SLIT2 promoted microglia/macrophage chemotaxis and tumor-supportive polarization via ROBO1&2-mediated PI3Kγ activation. Macrophage Robo1&2 deletion and systemic SLIT2 trap delivery mimicked SLIT2 knockdown effects on tumor growth and the tumor microenvironment (TME), revealing SLIT2 signaling through macrophage ROBOs as a novel regulator of the GBM microenvironment and a potential immunotherapeutic target for brain tumors.

Trigonelline-loaded chitosan nanoparticles prompted antitumor activity on glioma cells and biocompatibility with pheochromocytoma cells

2020 ◽  
Vol 163 ◽  
pp. 36-43 ◽  
Author(s):  
Anbazhagan Sathiyaseelan ◽  
Kandasamy Saravanakumar ◽  
Jothi Jayalakshmi ◽  
Margabandhu Gopi ◽  
Azeez Shajahan ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Chitosan Nanoparticles ◽  
Glioma Cells ◽  
Pheochromocytoma Cells
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