scholarly journals Therapeutic Potential of Neurotrophic Factors and Neural Stem Cells Against Ischemic Brain Injury

2000 ◽  
Vol 20 (10) ◽  
pp. 1393-1408 ◽  
Author(s):  
Koji Abe
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Neurotrophic Factors ◽  
Therapeutic Potential ◽  
Stem Cell Differentiation ◽  
Adult Brain ◽  
Ischemic Brain Injury ◽  
Ischemic Brain

Development of neuronal and glial cells and their maintenance are under control of neurotrophic factors (NTFs). An exogenous administration of NTFs protects extremely sensitive brain tissue from ischemic damage. On the other hand, it is now known that neural stem cells are present in normal adult brain, and have a potential to compensate and recover neural functions that were lost due to ischemic stroke. These stem cells are also under control of NTFs to differentiate into a certain species of neural cells. Thus, the purpose of this review is to summarize the present understanding of the role of NTFs in normal and ischemic brain and the therapeutic potential of NTF protein itself or gene therapy, and then to summarize the role of NTFs in stem cell differentiation and a possible therapeutic potential with the neural stem cells against ischemic brain injury.

scholarly journals Insights into the Biology and Therapeutic Applications of Neural Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-18 ◽  
Author(s):  
Lachlan Harris ◽  
Oressia Zalucki ◽  
Michael Piper ◽  
Julian Ik-Tsen Heng
Keyword(s):  
Stem Cells ◽  
Cerebral Cortex ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Human Brain ◽  
Therapeutic Potential ◽  
Biological Significance ◽  
Adult Brain ◽  
Cognitive Capacity ◽  
Molecular Characteristics

The cerebral cortex is essential for our higher cognitive functions and emotional reasoning. Arguably, this brain structure is the distinguishing feature of our species, and yet our remarkable cognitive capacity has seemingly come at a cost to the regenerative capacity of the human brain. Indeed, the capacity for regeneration and neurogenesis of the brains of vertebrates has declined over the course of evolution, from fish to rodents to primates. Nevertheless, recent evidence supporting the existence of neural stem cells (NSCs) in the adult human brain raises new questions about the biological significance of adult neurogenesis in relation to ageing and the possibility that such endogenous sources of NSCs might provide therapeutic options for the treatment of brain injury and disease. Here, we highlight recent insights and perspectives on NSCs within both the developing and adult cerebral cortex. Our review of NSCs during development focuses upon the diversity and therapeutic potential of these cells for use in cellular transplantation and in the modeling of neurodevelopmental disorders. Finally, we describe the cellular and molecular characteristics of NSCs within the adult brain and strategies to harness the therapeutic potential of these cell populations in the treatment of brain injury and disease.

scholarly journals Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury

2019 ◽  
Vol 26 (1) ◽  
pp. 1-16
Author(s):  
Jeong Eun Shin ◽  
Jungho Han ◽  
Joo Hee Lim ◽  
Ho Seon Eun ◽  
Kook In Park
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Translational Research ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Human Neural Stem Cells ◽  
Hypoxic Ischemic Brain Injury
Sign in / Sign up

Export Citation Format

Share Document