ENDOPROSTHETIC BONE RECONSTRUCTION FOLLOWING MALIGNANT TUMOR RESECTION IN SKELETALLY IMMATURE PATIENTS

Author(s):  
&NA;
2014 ◽  
Vol 10 (4) ◽  
pp. 649-653 ◽  
Author(s):  
Malik Zaben ◽  
Mohsin Zafar ◽  
Shafqat Bukhari ◽  
Paul Leach ◽  
Charoline Hayhurst

Abstract BACKGROUND: Sella and suprasellar tumors are increasingly managed via an endoscopic transsphenoidal approach, but infant endoscopic surgery has not been reported. Pituitary blastoma is a rare sellar malignant tumor that primarily occurs in infants and is managed by surgical resection (cytoreduction) followed by adjuvant therapy. OBJECTIVE: To describe the technique and feasibility of resection of a pituitary blastoma via endoscopic endonasal transsphenoidal approach in an 18-month-old infant. METHODS: Endoscopic endonasal transsphenoidal approach for resection of a pituitary malignant tumor in an infant. RESULTS: Near-total tumor resection was achieved. The skull base was reconstructed by using a nasoseptal flap with no cerebrospinal fluid leak or any other intraoperative complications. The postoperative course was uneventful. One-year follow-up showed complete resolution of the tumor. CONCLUSION: The endoscopic endonasal transsphenoidal approach with nasoseptal flap reconstruction could be used as a safe, yet minimally invasive and innovative technique for the resection of pituitary blastoma in infants.


2014 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lu Wang ◽  
Fengzhi Xu ◽  
Guo-Kang Fan ◽  
Wenpeng Li ◽  
Lei Shen

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Maryam Seyedmajidi ◽  
Seyedmahmood Rabiee ◽  
Sina Haghanifar ◽  
Seyedkamal Seyedmajidi ◽  
Seyed Gholam ali Jorsaraei ◽  
...  

Background. Bone defects following tumor resection and osteolysis due to bone lesions, periodontal tissue disorders, and bone reconstruction are challenges that surgeons face. Gass-ceramic-chitosan nanocomposite contains chitosan, a derivative of crustaceans’ exoskeleton.Methods. Thirty-two 6–8-week-old male Wistar rats were chosen. One hole on each right and left tibia was made. The right tibia holes were filled with injectable glass-ceramic-chitosan nanocomposite, and the left tibia holes were left empty. After 7, 14, 28, and 60 days, histopathological, histomorphometrical, and radiographical assessments were performed.Results. Radiographic density on days 7 and 14 was significantly higher in the right tibias than in the left tibias. Trabecular bone thickness, which was higher in the right tibias, increased from day 7 to day 60 in both right and left tibias, although not significantly.Conclusions. Glass-ceramic-chitosan nanocomposite is suggested for use in bone repair in cases of bone loss. More histopathological, histomorphometrical, and radiographical assessments are also recommended.


2011 ◽  
Vol 22 (6) ◽  
pp. 2208-2211 ◽  
Author(s):  
Bi Bo ◽  
Yang Qun ◽  
Pu Zheming ◽  
Xiao Haitao ◽  
Liu Tianyi

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yasong Liu ◽  
Wentao Xu

The study aimed to analyze the application of diffusion tensor imaging (DTI) in the surgery of benign and malignant intracranial tumors through improved fuzzy C-means (FCM). First, a method of combining the maximum and minimum distances was proposed to improve the FCM algorithm. Then, the optimized FCM was applied to the diffusion tensor imaging (DTI) diagnosis. The patients were rolled into the benign tumor group and the malignant tumor group, and relevant parameters were compared. Finally, the postoperative total resection rate and disability rate of the DTI experimental group and the traditional control (Ctrl) group were evaluated. It was found that the segmentation accuracy of the optimized FCM algorithm was higher than traditional one and the obtained corpus callosum edge contour was clearer. In 63 patients with intracranial space, there were obvious differences in pairwise comparison of meningioma and glioma, metastatic tumor’s apparent diffusion coefficient (ADC) value, relative apparent diffusion coefficient (r ADC) value, and relative anisotropy fraction (r FA) P < 0.05 . In terms of the ADC, r ADC, and r FA values of tumor parenchymal area, those of benign tumors were larger than malignant tumors P < 0.05 . The ADC value (8.21 ± 1.87) and r FA value (1.36 ± 0.41) of the contralateral normal white matter area of malignant tumor were greater than the ADC value (7.23 ± 2.31) and r FA value (0.61 ± 0.24) of the peritumor white matter area, with statistically significant differences P < 0.05 . The total cut rates of the experimental group and the Ctrl were 87.5% and 54.84%, and the disability rates were 6.25% and 34.38%. In conclusion, the optimized FCM has high accuracy. The ADC, r ADC, and r FA values of DTI are important in the diagnosis of intracranial tumors. Besides, DTI can improve the survival rate in guiding intracranial tumor resection.


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