A Multicenter, Double-Blind Comparison of the Effects of Nefazodone and Fluoxetine on Sleep Architecture and Quality of Sleep in Depressed Outpatients

We propose a fully parametric approach to the assessment of sleep architecture, based upon the classical electroencephalographic criteria, applicable also to the recordings of patients with disorders of consciousness (DOC). Sleep spindles and slow waves are automatically detected from the matching pursuit decomposition of overnight EEG recordings. Their evolution can be presented in the form of EEG profiles, yielding a continuous description of sleep architecture, compatible with the classical criteria used in sleep staging. We propose assessment of these EEG profiles by five parameters, which can be combined by a linear classifier, assessing the quality of sleep architecture. Proposed methodology is evaluated on 59 overnight EEG recordings from 19 patients from a hospital for children with severe brain damage, in relation to their behavioral diagnosis according to the Coma Recovery Scale-Revised. Presented results indicate robustness of the proposed approach, which may serve as a valuable aid in diagnosis of DOC patients. Complete software environment for computing and presentation of EEG profiles is freely available from http://svarog.pl .

Download Full-text

Epidural Pethidine or Fentanyl during Caesarean Section: A Double-Blind Comparison

Anaesthesia and Intensive Care ◽

10.1177/0310057x8901700206 ◽

1989 ◽

Vol 17 (2) ◽

pp. 157-165 ◽

Cited By ~ 11

Author(s):

M. J. Paech

Keyword(s):

Side Effects ◽

Caesarean Section ◽

Epidural Fentanyl ◽

Double Blind Study ◽

Double Blind ◽

Significant Difference ◽

Single Bolus Dose ◽

Clinical Advantage ◽

Blind Comparison

The onset, quality and duration of analgesia and side-effects of a single bolus dose of either epidural pethidine 50 mg or fentanyl 100 mcg, administered immediately post-delivery, were compared in a randomised, double-blind study of fifty-five women undergoing epidural caesarean section. The onset of effect was more rapid with fentanyl, a significantly larger number of women achieving complete pain relief fifteen minutes post-administration (P<0.05). The quality of analgesia was good in both groups and the quality and duration of effective analgesia not significantly different. The incidence and severity of side-effects were low, with no significant difference between groups. One patient in the pethidine group experienced early onset respiratory depression; however, she did not require active treatment. Epidural fentanyl 100 mcg appears to offer a small clinical advantage over pethidine 50 mg for intraoperative use during caesarean section.

Download Full-text

Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: Randomized, controlled, double-blind pilot study

Gynecological Endocrinology ◽

10.1080/09513590701200900 ◽

2007 ◽

Vol 23 (2) ◽

pp. 117-122 ◽

Cited By ~ 37

Author(s):

Carmela Rotem ◽

Boris Kaplan

Keyword(s):

Pilot Study ◽

Hot Flushes ◽

Quality Of Sleep ◽

Double Blind ◽

Randomized Controlled ◽

Night Sweats

Download Full-text

A Controlled Study of Trancopal in Sleep Disturbances Due to Rheumatic Disease

Journal of International Medical Research ◽

10.1177/030006057800600207 ◽

1978 ◽

Vol 6 (2) ◽

pp. 111-114 ◽

Cited By ~ 16

Author(s):

L Cohen

Keyword(s):

Sleep Disturbances ◽

The Elderly ◽

Controlled Study ◽

Double Blind Study ◽

Quality Of Sleep ◽

Double Blind ◽

Acceptable Alternative ◽

Daily Record ◽

Rheumatic Patients

A placebo controlled, double-blind study was carried out in six centres in general practice to assess the effectiveness of Trancopal in treating sleep disturbances due to rheumatic disorders. Eighty-five patients received a usual dose of two tablets of Trancopal or matching placebo at night for two weeks. Patients were assessed weekly and kept a daily record of the quality of sleep. All ratings showed that patients slept significantly better on Trancopal than on placebo. Day-time rheumatic stiffness however was not significantly reduced. Six patients receiving Trancopal reported side-effects chiefly drowsiness (five patients) which was controlled by dose reduction. It was concluded that for rheumatic patients Trancopal offers an acceptable alternative to current hypnotics over which it may prove to have some advantages, particularly for the elderly.

Download Full-text

Epilepsy, Antiseizure Therapy, and Sleep Cycle Parameters

Epilepsy Research and Treatment ◽

10.1155/2013/670682 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8 ◽

Cited By ~ 5

Author(s):

Vladimir Shvarts ◽

Steve Chung

Keyword(s):

Reciprocal Relationship ◽

Sleep Architecture ◽

Sleep Cycle ◽

Therapeutic Effects ◽

Quality Of Sleep ◽

Antiepileptic Therapy ◽

Quality Of Life Measures ◽

Pharmacologic Agents ◽

The Relationship

A reciprocal relationship exists between sleep and epilepsy. The quality of sleep is affected by the presence and frequency of seizures, type of antiepileptic therapy utilized, and coexisting primary sleep disorders. Daytime somnolence is one of the most common adverse effects of antiepileptic therapy, with specific pharmacologic agents exhibiting a unique influence on components of sleep architecture. The newer generation of antiseizure drugs demonstrates improved sleep efficiency, greater stabilization of sleep architecture, prolongation of REM sleep duration, and increased quality of life measures. The emerging field of chronoepileptology explores the relationship between seizures and circadian rhythms, aiming for targeted use of antiseizure therapies to maximize therapeutic effects and minimize the adverse events experienced by the patients.

Download Full-text

A Clinical Trial of Electrosleep Therapy with a Psychiatric Inpatient Sample

Australian & New Zealand Journal of Psychiatry ◽

10.3109/00048677509159864 ◽

1975 ◽

Vol 9 (4) ◽

pp. 287-290 ◽

Cited By ~ 7

Author(s):

Eugene A. Levitt ◽

Norman McI. James ◽

Philippa Flavell

Keyword(s):

Clinical Trial ◽

Psychiatric Inpatient ◽

The Other ◽

Quality Of Sleep ◽

Double Blind ◽

Symptoms Of Depression ◽

Treatment Of Depression ◽

Sleep Difficulties ◽

Better Than

The study assessed the effectiveness of electrosleep therapy in the treatment of depression, anxiety, and sleep difficulties in a small, heterogeneous sample of psychiatric inpatients. A double-blind format was employed, one group receiving active treatment while the other received simulated treatment. The results showed active electrosleep to be no better than placebo in bettering quality of sleep or in lessening symptoms of depression or anxiety.

Download Full-text

Nitrazepam and Temazepam: A Comparative Trial of Two Hypnotics

Journal of International Medical Research ◽

10.1177/030006057600400301 ◽

1976 ◽

Vol 4 (3) ◽

pp. 145-151 ◽

Cited By ~ 13

Author(s):

R G Priest ◽

Z A Rizvi

Keyword(s):

Patient Satisfaction ◽

Psychiatric Patients ◽

Comparative Trial ◽

Quality Of Sleep ◽

Double Blind ◽

Sleep Questionnaire ◽

Hypnotic Drugs ◽

Benzodiazepine Drugs

A specially designed sleep questionnaire was used to assess the performance of the two hypnotic drugs. Psychiatric patients were given 5 mg nitrazepam or 10 mg temazepam in identical capsules, and were allowed more if necessary. A double-blind cross-over design was used. We found that 5·2 mg nitrazepam showed few differences from 13·2 mg temazepam. The two regimes produced fairly similar reports on patient satisfaction, quality of sleep, number of awakenings, depth of sleep and other variables. Patients on nitrazepam were a little more clear-headed in the morning, though they tended to wake later, sleep longer, and take more sleep over the 24-hour period. No toxicity was found with either drug over the 434 patient days of administration. In view of the advantages of the benzodiazepine drugs over their predecessors, we feel that it is worth exploring further the use of temazepam as a sleep inducing drug.

Download Full-text